Results 81 to 90 of about 216,238 (188)

Microglial reactivity and nodule formation are associated with Synaptodendritic damage in the brains of people with HIV‐1

Brain Pathology, Volume 36, Issue 3, May 2026.
Despite effective ART, neurocognitive impairment persists in people with HIV. Brains from PWH present exacerbated microgliosis and formation of microglial nodules that are actively engaged in neuronal phagocytosis, resulting in neuronal injury and dendritic loss.
Roberta S. Dos Reis, Lauren A. Ignatz, Sathish Selvam, Marc C. E. Wagner, Sara Gianella, Antoine Chaillon, Vanessa Gomez‐Moreno, Jeremy Martison, Leah H. Rubin, Sabina Heberlen, Valentina Stosor, Jordan Lake, Velpandi Ayyavoo   +12 more
wiley   +1 more source

Bruton tyrosine kinase (Btk) in neutrophils is indispensable for initiating and maintaining skin inflammation in a model of pemphigoid diseases

British Journal of Pharmacology, Volume 183, Issue 10, Page 2446-2463, May 2026.
Background and Purpose Bruton tyrosine kinase (Btk) is essential for B cell function. Its role in myeloid cells is less understood. Greater insights into Btk significance in myeloid cells are needed to evaluate its potential as a therapeutic target during the effector phase of antibody‐induced autoimmune diseases, where inhibiting autoantibody ...
Henning Olbrich, Paul Schilf, Sripriya Murthy, Sina Gonther, Mareike Neumann, Christoph M. Hammers, Jasper N. Pruessmann, Christian D. Sadik   +7 more
wiley   +1 more source

Long-Term Low Income Housing Tax Credit Policy Questions [PDF]

, 2010
Discusses Low Income Housing Tax Credit policy questions such as whether to target the lowest-income families, issues such as geographic gaps in tax credit investment demand, and ongoing capital needs and asset management for LIHTC ...

core  

β3‐adrenoceptor agonism exerts lung protection in a rat model of bronchopulmonary dysplasia

British Journal of Pharmacology, Volume 183, Issue 10, Page 2497-2517, May 2026.
The β3‐adrenoceptors agonist BRL37344 promotes lung maturation, preventing the progression of experimental bronchopulmonary dysplasia. Absract Background and Purpose Bronchopulmonary dysplasia (BPD) affects premature newborns, particularly those receiving supplemental oxygen therapy.
Alessandro Pini, Patrizia Nardini, Virginia Zizi, Marta Molino, Maura Calvani, Francesco Carrozzo, Rachele Amato, Daniele Guasti, Denise Biagini, Fabio di Francesco, Ludovico Silvestri, Alessandra Franceschini, Daniele Bani, Elisa Imbimbo, Luca Filippi   +14 more
wiley   +1 more source

TGF‐β Inhibitor Potentiates Osimertinib‐Induced Anti‐Tumor Immunity in Egfr‐Mutant Lung Cancer

Cancer Science, Volume 117, Issue 5, Page 1260-1272, May 2026.
Osimertinib enhances CD8+ T cell activity but also upregulates immunosuppressive TGF‐β in Egfr‐mutant lung tumors. This study demonstrates that TGF‐β inhibition with nintedanib or vactosertib potentiates osimertinib‐induced CD8+ T cell–mediated immunity and reduce CD206+ macrophages. These findings provide a strong rationale for novel immunotherapeutic
Tadahiro Kuribayashi, Jun Nishimura, Sachi Okawa, Masataka Taoka, Shunta Mori, Takaaki Tanaka, Tomoka Nishimura, Ayako Morita, Naofumi Hara, Kiichiro Ninomiya, Go Makimoto, Kammei Rai, Eiki Ichihara, Katsuyuki Hotta, Yosuke Togashi, Yoshinobu Maeda, Katsuyuki Kiura, Kadoaki Ohashi   +17 more
wiley   +1 more source

Making Accurate Judgements in Child Welfare: Comparing ChatGPT With Qualified Social Workers

Child &Family Social Work, Volume 31, Issue 2, Page 703-712, May 2026.
ABSTRACT This study compares the judgemental accuracy of child and family social workers (n = 581) with ChatGPT, a generative AI model. Using 12 anonymized referrals, participants were asked predictive questions to evaluate accuracy through Brier scores. ChatGPT outperformed the average social worker on 11 of the 12 referrals, though the difference was
David Wilkins, Verity Benett
wiley   +1 more source

Signal Transducer and Activator of Transcription (STAT) Proteins Regulate Mucosal‐Associated Invariant T (MAIT) Cell Function

Immunology, Volume 178, Issue 1, Page 97-108, May 2026.
Integrated transcriptomic, proteomic and flow cytometry analyses reveal that STAT1 negatively regulates MAIT cell effector and glycolytic functions, while STAT3, STAT5 and HIF1α act as positive modulators. Targeting these pathways may offer new strategies to restore MAIT cell function in immune dysregulation and cancer.
Olivia J. Cheng, Eimear K. Ryan, Michael Bennett, Christy Clutter, Jackson G. Cacioppo, Jeffrey Aubé, Andy E. Hogan, Daniel T. Leung   +7 more
wiley   +1 more source

Ethical Challenges and Strategies in Nursing Doctoral Supervision: A Systematic Mixed‐Method Review

Journal of Advanced Nursing, Volume 82, Issue 5, Page 4167-4184, May 2026.
ABSTRACT Aim To identify and address ethical challenges in doctoral supervision within nursing and health sciences and propose strategies to overcome them. Design Following PRISMA guidelines, this mixed‐method systematic review synthesises findings from quantitative, qualitative and mixed‐methods studies published in English between 2014 and 2025 ...
Tove Godskesen, Maria Grandahl, Amalie Nilsen Hagen, Stefan Eriksson   +3 more
wiley   +1 more source

Access to Communication Assessment and Intervention for Adults With Intellectual Disabilities

Journal of Applied Research in Intellectual Disabilities, Volume 39, Issue 3, May 2026.
ABSTRACT Background Effective communication is essential for health, quality of life and social participation. Adults with communication disabilities—particularly those with intellectual disabilities—often face systemic barriers to accessing appropriate support.
Caitlin Chaney, Ann Nguyen Do, Amanda Elitawi, Brooke Carrier, Emma Charters   +4 more
wiley   +1 more source

MafB is a conserved transcriptional regulator of macrophage development and functional identity across tissues and species. [PDF]

Immunity
Vanneste D, Peng W, Liu Z, Hamaïdia M, La Rocca R, Abinet J, Balthazar A, Perin F, Hego A, Cataldo D, Bureau F, Compère P, Machiels B, Scott CL, Radermecker C, Marichal T.   +15 more
europepmc   +1 more source