Molecules, 2017 Ultrasound-assisted extraction (UAE), using petroleum ether as the solvent, was systematically applied to extract main macamides and macaenes from Maca hypocotyls.
Ke-Ke Li, Xiao-Jie Gong
exaly +3 more sources
Antioxidant, Neuroprotective, and Antinociceptive Effects of Peruvian Black Maca (Lepidium meyenii Walp.) [PDF]
AntioxidantsLepidium meyenii Walp. (black maca, BM) is a traditional Andean crop increasingly studied for its bioactive potential. This work characterized the phytochemical profile and evaluated the antioxidant, antinociceptive, and neuroprotective properties of a ...
Iván M. Quispe-Díaz +11 more
doaj +2 more sources
Neuroprotection of N-benzyl Eicosapentaenamide in Neonatal Mice Following Hypoxic–Ischemic Brain Injury [PDF]
Molecules, 2021 Maca (Lepidium meyenii) has emerged as a popular functional plant food because of its medicinal properties and nutritional value. Macamides, as the exclusively active ingredients found in maca, are a unique series of non-polar, long-chain fatty acid N ...
Mengya Jiao +7 more
doaj +2 more sources
Synergism of Specific Maca Phenotypes (Lepidium peruvianum) in Combination with Saw Palmetto (Serenoa repens) Extract for Chemoprevention of Prostate Cancer as Determined in In Vitro Cytotoxicity Assays on Human Epithelial and Prostate Cancer Cells [PDF]
MoleculesSelected phenotypes of dried maca (Lepidium peruvianum) hypocotyls and supercritical CO2 extract (USPlus®) of saw palmetto (Serenoa repens) were used to determine their targeted, cytotoxic action in prostate cancer cells.
Katarzyna Gaweł-Bęben +6 more
doaj +2 more sources
Macamide B suppresses lung cancer progression potentially via the ATM signaling pathway. [PDF]
Oncol Lett, 2023 Macamides are a class of bioactive natural products obtained from Lepidium meyenii (maca), which have been reported to exert inhibitory activity in cancer. However, their role in lung cancer is currently unknown. In the present study, macamide B was shown to inhibit the proliferation and invasion of lung cancer cells, as determined by Cell Counting Kit-
Tao H, Shi H, Wang M, Xu Y.
europepmc +3 more sources
Evaluation of the effect of Lepidium meyenii Walpers in infertile patients: A randomized, double-blind, placebo-controlled trial. [PDF]
Phytother Res, 2021 Male infertility refers to the inability to conceive a natural pregnancy in a fertile female, and approximately 15% of reproductive‐aged couples worldwide face this problem. Several plants were used to treat fertility disorders and, among them, Lepidium meyenii, a folk medicament of Andean regions, is still used to enhance vitality and treat sterility ...
Melnikovova I +8 more
europepmc +2 more sources
Activity of Lepidium meyenii Walp (purple maca) in immunosuppressed Oryctolagus cuniculus (albino rabbits) [PDF]
Pharmacia, 2022 Various properties are attributed to “maca”, including immunomodulatory properties due to its secondary metabolites such as macamides, glucosinolates, isothiocyanates and flavonoids. Immunosuppression, hemolytic anemia, and thymic involution were induced
Angel T. Alvarado +7 more
doaj +3 more sources
Synthesis and biological screening of a library of macamides as TNF-α inhibitors. [PDF]
RSC Med Chem, 2020 Thirty-five macamide analogues were synthesised by modifying the initial molecular structure.
Tena Pérez V +4 more
europepmc +5 more sources
Deep Eutectic Solvents: An Eco‐friendly Design for Drug Engineering
ChemSusChem, Volume 16, Issue 20, October 20, 2023., 2023 Deep eutectic solvents (DESs) appeared as an alternative to harmful organic solvents. This review presents a framework for understanding the development process of DESs, starting from the main parameters for judiciously selecting the DES components, then highlighting the methods of preparation and characterization, and ending with explaining the role ...
Feras Oyoun +7 more
wiley +1 more source
iMeta, Volume 2, Issue 3, August 2023., 2023 We successfully isolated Maca‐EVs using ultracentrifugation and tested its antidepressant effects in the unpredictable chronic mild stress mice. Maca‐EVs increased serum serotonin (5‐HT) levels probably via the gut microbiota and metabolism modulation.
Rui Hong +14 more
wiley +1 more source