Results 181 to 190 of about 79,205 (258)

Vibrotactile intensity perception: Predominant influence of afferents recruited remote from stimulus site

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend We delivered trains of brief mechanical pulses to the fingertips of subjects to investigate vibrotactile intensity perception. Some stimuli consisted of bursts of up to four pulses. Simulated responses of the tactile afferent population across the hand revealed that afferents innervating the skin directly under the probe reliably
Kevin K. W. Ng   +2 more
wiley   +1 more source

Detection and Removal of Hyper-synchronous Artifacts in Massively Parallel Spike Recordings. [PDF]

open access: yesJ Neurosci
Oberste-Frielinghaus J   +10 more
europepmc   +1 more source

Single human fingertip mechanoreceptive afferents simultaneously encode multidimensional aspects of touch

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Mechanoreceptors in the fingertip skin allow us to explore objects and to feel a vast range of textures. We recorded responses from individual low‐threshold mechanoreceptive afferents in humans while dynamic stimuli were swept across their receptive fields, systematically varying force, velocity and spatial period.
Victoria Ashley Lang   +3 more
wiley   +1 more source

Pre-existing immunity to heartland virus protects rhesus macaques from challenge with severe fever with thrombocytopenia syndrome virus. [PDF]

open access: yesEmerg Microbes Infect
Bisom T   +7 more
europepmc   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

open access: yesMedicinal Research Reviews, Volume 46, Issue 6, Page 1477-1498, November 2026.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood   +7 more
wiley   +1 more source

Coordinated neural progenitor adaptations contribute to primate neocortical downscaling. [PDF]

open access: yesSci Adv
Tynianskaia L   +13 more
europepmc   +1 more source

Brain viral reservoir seeding and neurological metabolic dysregulation in early‐life immunodeficiency virus infection

open access: yesBrain Pathology, Volume 36, Issue 6, November 2026.
Brain viral reservoirs were undetectable in neonatal SIV during the first 3 days post infection; antiretroviral therapy (ART) at 3 dpi prevented brain reservoir seeding and normalized metabolic function, highlighting the necessity of very early treatment to protect the developing CNS.
Li Ma   +12 more
wiley   +1 more source

Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery

open access: yesAdvanced Science, Volume 13, Issue 55, 5 October 2026.
Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae   +27 more
wiley   +1 more source

Inferring the Landscapes of Mutation and Recombination in the Common Marmoset (Callithrix jacchus) in the Presence of Twinning and Hematopoietic Chimerism

open access: yesAmerican Journal of Primatology, Volume 88, Issue 10, October 2026.
Using high‐quality population genomic data, Soni, Versoza and colleagues infer the rates and landscapes of mutation and recombination in the common marmoset (Callithrix jacchus)—two fundamental processes dictating the levels and patterns of genetic variability—within the context of two biological peculiarities related to the reproductive mode of the ...
Vivak Soni   +3 more
wiley   +1 more source

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