Results 181 to 190 of about 79,205 (258)
Abstract figure legend We delivered trains of brief mechanical pulses to the fingertips of subjects to investigate vibrotactile intensity perception. Some stimuli consisted of bursts of up to four pulses. Simulated responses of the tactile afferent population across the hand revealed that afferents innervating the skin directly under the probe reliably
Kevin K. W. Ng +2 more
wiley +1 more source
Detection and Removal of Hyper-synchronous Artifacts in Massively Parallel Spike Recordings. [PDF]
Oberste-Frielinghaus J +10 more
europepmc +1 more source
Abstract figure legend Mechanoreceptors in the fingertip skin allow us to explore objects and to feel a vast range of textures. We recorded responses from individual low‐threshold mechanoreceptive afferents in humans while dynamic stimuli were swept across their receptive fields, systematically varying force, velocity and spatial period.
Victoria Ashley Lang +3 more
wiley +1 more source
Pre-existing immunity to heartland virus protects rhesus macaques from challenge with severe fever with thrombocytopenia syndrome virus. [PDF]
Bisom T +7 more
europepmc +1 more source
Facial expression discrimination emerges from partially overlapping neural subspaces of detection and identity. [PDF]
Wehrheim M +3 more
europepmc +1 more source
Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood +7 more
wiley +1 more source
Coordinated neural progenitor adaptations contribute to primate neocortical downscaling. [PDF]
Tynianskaia L +13 more
europepmc +1 more source
Brain viral reservoirs were undetectable in neonatal SIV during the first 3 days post infection; antiretroviral therapy (ART) at 3 dpi prevented brain reservoir seeding and normalized metabolic function, highlighting the necessity of very early treatment to protect the developing CNS.
Li Ma +12 more
wiley +1 more source
Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae +27 more
wiley +1 more source
Using high‐quality population genomic data, Soni, Versoza and colleagues infer the rates and landscapes of mutation and recombination in the common marmoset (Callithrix jacchus)—two fundamental processes dictating the levels and patterns of genetic variability—within the context of two biological peculiarities related to the reproductive mode of the ...
Vivak Soni +3 more
wiley +1 more source

