Results 201 to 210 of about 79,205 (258)

CRISPR‐based therapeutic and modelling approaches in Huntington's disease: Progress, challenges and future directions

open access: yesClinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Clustered regularly interspaced short palindromic repeat (CRISPR) is transforming Huntington's disease research through allele‐selective huntingtin (HTT) targeting, transcriptional and RNA suppression, and advanced disease modelling. Progress towards precision therapy depends on safe central nervous system (CNS) delivery, reduced off‐target and immune ...
Kairat Zhakipbekov   +11 more
wiley   +1 more source

Expression patterns of risk genes associated with three evolutionarily relevant syndromes in rhesus macaque and human brains. [PDF]

open access: yesTransl Psychiatry
Karunakaran KB   +5 more
europepmc   +1 more source

Sociability Under Anthropogenic Change: From Individual Behaviour to Population‐Level Consequences

open access: yesEcology and Evolution, Volume 16, Issue 10, October 2026.
Our review synthesises empirical and theoretical research on how anthropogenic environmental change reshapes animal social behaviour from individuals to populations. We use sociability as an individual‐level lens, distinguishing context‐dependent expression from repeatable interindividual differences and linking both to social relationships, network ...
Paulina Kowalczyk, Barbara Pietrzak
wiley   +1 more source

Individualised Structural and Functional Frontostriatal Connectivity Mapping in Adult ADHD

open access: yesHuman Brain Mapping, Volume 47, Issue 14, October 1, 2026.
We identified compromised structural and functional frontostriatal connectivity in adults with attention deficit hyperactivity disorder via individualised connectivity mapping. ABSTRACT Abundant research from early neurocognitive models to recent mega‐analyses has highlighted the central role of frontostriatal circuits in attention deficit ...
Tuija Tolonen   +7 more
wiley   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

open access: yesMedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao   +5 more
wiley   +1 more source

Complex subtelomeric architectures in a complete rhesus macaque reference genome. [PDF]

open access: yesCell
Zhang S   +19 more
europepmc   +1 more source

Task‐Related Neurotransmitter Dynamics in the Visual Cortex: A Proof‐of‐Concept Time‐Resolved fMRS Study Using a Sustained Vigilance Paradigm

open access: yesNMR in Biomedicine, Volume 39, Issue 10, October 2026.
Using time‐resolved fMRS at 3T, we observed task‐evoked increases in Glx within the human primary visual cortex during sustained vigilance paradigm. Glx dynamics showed an exploratory association with behavioral performance. These findings suggest that time‐resolved fMRS may capture excitatory neurochemical changes related to sustained visual ...
I‐Ting Lee   +4 more
wiley   +1 more source

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