Results 31 to 40 of about 56,299 (265)

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Antiviral Innate Responses Induced by VSV-EBOV Vaccination Contribute to Rapid Protection

mBio, 2019
Ebola virus (EBOV) is a single-stranded RNA virus that causes Ebola virus disease (EVD), characterized by excessive inflammation, lymphocyte apoptosis, hemorrhage, and coagulation defects leading to multiorgan failure and shock.
Andrea R. Menicucci, Allen Jankeel, Heinz Feldmann, Andrea Marzi, Ilhem Messaoudi   +4 more
doaj   +1 more source

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Male consort behavior is driven by female mate choice and receptive synchrony in Tibetan macaques (Macaca thibetana)

Global Ecology and Conservation
In group-living animals, males’ fighting abilities were usually mediated via dominance rank to sort males into a queue to access fertile females, especially in non-human primates. However, the correlation between male reproductive success and consortship,
Qi-Xin Zhang, Yong Zhu, Dong-Po Xia, Xi Wang, Jin-Hua Li   +4 more
doaj   +1 more source

Evaluation in Nonhuman Primates of Vaccines against Ebola Virus

Emerging Infectious Diseases, 2002
Ebola virus (EBOV) causes acute hemorrhagic fever that is fatal in up to 90% of cases in both humans and nonhuman primates. No vaccines or treatments are available for human use.
Thomas W. Geisbert, Peter Pushko, Kevin Anderson, Jonathan Smith, Kelly J. Davis, Peter B. Jahrling   +5 more
doaj   +1 more source

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, EarlyView.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source

Collective decision-making in nocturnal huddling sleep: The influence of social factors on fans and fandom in Tibetan macaques

Global Ecology and Conservation
Social animals frequently exhibit huddling sleep behaviors in response to nocturnal ecological pressures. However, there remain significant gaps in our understanding of the decision-making process promoting huddle sleep.
Juan Chen, Peipei Yang, Qixin Zhang, Wenbo Li, Xi Wang, Jinhua Li   +5 more
doaj   +1 more source

Translatability of Scalp EEG Recordings of Duration-Deviant Mismatch Negativity Between Macaques and Humans: A Pilot Study

Frontiers in Psychiatry, 2020
Mismatch negativity (MMN) is a negative deflection of the auditory event-related potential (ERP) elicited by an abrupt change in a sound presented repeatedly.
Mariko Tada, Mariko Tada, Yuki Suda, Yuki Suda, Kenji Kirihara, Daisuke Koshiyama, Mao Fujioka, Kaori Usui, Tsuyoshi Araki, Kiyoto Kasai, Kiyoto Kasai, Takanori Uka, Takanori Uka   +12 more
doaj   +1 more source

Surveillance of Daughter Micronodule Formation Is a Key Factor for Vaccine Evaluation Using Experimental Infection Models of Tuberculosis in Macaques

Pathogens, 2023
Tuberculosis (TB) is still a major worldwide health problem and models using non-human primates (NHP) provide the most relevant approach for vaccine testing.
Isabel Nogueira, Martí Català, Andrew D. White, Sally A Sharpe, Jordi Bechini, Clara Prats, Cristina Vilaplana, Pere-Joan Cardona   +7 more
doaj   +1 more source

Positional Inference in Rhesus Macaques

Animal Cognition, 2020
Understanding how organisms make transitive inferences is critical to understanding their general ability to learn serial relationships. In this context, transitive inference (TI) can be understood as a specific heuristic that applies broadly to many different serial learning tasks, which have been the focus of hundreds of studies involving dozens of ...
Greg Jensen, Vincent P. Ferrera, Herbert S. Terrace   +2 more
openaire   +3 more sources