Results 41 to 50 of about 56,299 (265)
Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
Advanced Science, EarlyView.Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae +27 more
wiley +1 more source
“Monkey influencers”: conservation culturomics of human-macaque (Macaca fascicularis) interactions
Global Ecology and ConservationConservation culturomics can offer insights into the online presence of threatened primate species, such as the long-tailed macaque (Macaca fascicularis).
Alice Fratesi +3 more
doaj +1 more source
Contextual factors explain risk-seeking preferences in rhesus monkeys
Frontiers in Neuroscience, 2013 In contrast to humans and most other animals, rhesus macaques strongly prefer risky rewards to safe ones with similar expected value. Why macaques prefer risk while other animals typically avoid it remains puzzling and challenges the idea that monkeys ...
Sarah eHeilbronner, Benjamin eHayden
doaj +1 more source
Frontiers in Systems Neuroscience, 2020 Most of the mammalian neocortex is comprised of a highly similar anatomical structure, consisting of a granular cell layer between superficial and deep layers. Even so, different cortical areas process different information. Taken together, this suggests
David A. Tovar +17 more
doaj +1 more source
Head-mounted microendoscopic calcium imaging in dorsal premotor cortex of behaving rhesus macaque
Cell Reports, 2021 Summary: Microendoscopic calcium imaging with one-photon miniature microscopes enables unprecedented readout of neural circuit dynamics during active behavior in rodents.
Anil Bollimunta +7 more
doaj +1 more source
Measles Studies in the Macaque Model [PDF]
, 2009 Much of our current understanding of measles has come from experiments in non-human primates. In 1911, Goldberger and Anderson showed that macaques inoculated with filtered secretions from measles patients developed measles, thus demonstrating that the causative agent of this disease was a virus.
R L, de Swart, R L, DeSwart
openaire +2 more sources
Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection
Advanced Science, EarlyView.Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse +20 more
wiley +1 more source
Advanced Science, EarlyView.Mice can transfer the learned rule of spatial working memory to guide similar but novel tasks. Hippocampal CA3 populational activity dynamically reorganize during memory generalization, shifting from task‐specific to generalized coding over testing days. Sparse yet redundant neural representations of CA3 enable rule transfer and cognitive map formation,
Da Song +8 more
wiley +1 more source
Frontiers in Neuroscience, 2010 Sensory decisions may be influenced by non-sensory information regarding reward magnitude or reward likelihood. Given identical sensory information, it is more optimal to choose an option if it is a priori more likely to be correct and hence rewarded ...
Tobias eTeichert, Vincent P Ferrera
doaj +1 more source
Frontiers in Immunology, 2022 The tuberculosis vaccine, Bacille Calmette-Guerin (BCG), also affords protection against non-tuberculous diseases attributable to heterologous immune mechanisms such as trained innate immunity, activation of non-conventional T-cells, and cross-reactive ...
Andrew D. White +28 more
doaj +1 more source