Results 111 to 120 of about 50,833 (303)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Mango peel extract as a green inhibitor in the corrosion of reinforced concrete

Journal of Electrochemical Science and Engineering
Chloride-induced corrosion of reinforcing steel embedded in concrete is a problem that causes the elements to lose their physical and mechanical properties and can lead to premature failures in civil works.
Alejandro Flores-Nicolás, Elsa Carmina Menchaca-Campos, Mario Flores-Nicolás   +2 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Integrating Sustainable Cultivation Practices and Advanced Extraction Methods for Improved Cannabis Yield and Cannabinoid Production

International Journal of Plant Biology
The rising global demand for medicinal cannabis necessitates the optimization of cultivation, harvesting, and extraction techniques to maximize cannabinoid yield and purity.
Theerayut Thawonkit, Nednapa Insalud, Rapeephun Dangtungee, Prakash Bhuyar   +3 more
doaj   +1 more source

Influence of enzymatic maceration on the microstructure and microhardness of compact bone

, 2016
The cleaning of fresh bones to remove their soft tissues while maintaining their structural integrity is a basic and essential part of bone studies. The primary issue is how the cleaning process influences bone microstructures and mechanical properties ...
Yin, Ling, Kalyanasundaram, Shankar, Venkatesan, Sudharshan, Qin, Qing Hua   +3 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Witchellia macer

, 2022
Published as part of Sandoval, José, 2022, Sonniniidae Ammonitina, Middle Jurassic from Southern Spain: taxonomic, biostratigraphical and palaeobiogeographical analysis, pp. 801-851 in Geodiversitas 44 (27) on pages 836-837, DOI: 10.5252/geodiversitas2022v44a27, http://zenodo.org/record ...
openaire   +2 more sources

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Untangling the impact of red wine maceration times on wine ageing. A multidisciplinary approach focusing on extended maceration in Shiraz wines

, 2021
\ua9 2021Phenolic composition of young red wines has been shown to play an important role in their ageing potential. Therefore, the modulation of phenolic extraction during maceration may influence the subsequent phenolic evolution of these wines.
du Toit WJ, Kuhlman B, Zietsman AJJ, Willats WGT, Moore JP, Schuckel J, Buica A, Garrido-Banuelos G   +7 more
core   +1 more source