Cerebellar morphometric and spectroscopic biomarkers for Machado-Joseph Disease [PDF]
Acta Neuropathologica Communications, 2022 Machado-Joseph disease (MJD) or Spinocerebellar ataxia type 3 (SCA3) is the most common form of dominant SCA worldwide. Magnetic Resonance Imaging (MRI) and Proton Magnetic Resonance Spectroscopy (1H-MRS) provide promising non-invasive diagnostic and ...
Catarina Oliveira Miranda +11 more
doaj +2 more sources
Neuropeptide Y (NPY) intranasal delivery alleviates Machado–Joseph disease [PDF]
Scientific Reports, 2021 Machado–Joseph disease (MJD) is the most common dominantly-inherited ataxia worldwide with no effective treatment to prevent, stop or alleviate its progression. Neuropeptide Y (NPY) is a neuroprotective agent widely expressed in the mammalian brain.
Joana Duarte-Neves +2 more
doaj +2 more sources
Trehalose alleviates the phenotype of Machado–Joseph disease mouse models [PDF]
Journal of Translational Medicine, 2020 Background Machado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is the most common of the dominantly inherited ataxias worldwide and is characterized by mutant ataxin-3 aggregation and neuronal degeneration.
Magda M. Santana +10 more
doaj +2 more sources
What is the best way to keep walking and moving around for individuals with Machado-Joseph disease? A scoping review through the lens of Aboriginal families with Machado-Joseph disease in the Top End of Australia [PDF]
BMJ Open, 2019 Objectives Machado-Joseph disease (MJD) is the most common spinocerebellar ataxia worldwide. Prevalence is highest in affected remote Aboriginal communities of the Top End of Australia.
Jennifer J Carr +7 more
doaj +2 more sources
Mesenchymal stem cell-derived exosomes improve motor function and attenuate neuropathology in a mouse model of Machado-Joseph disease [PDF]
Stem Cell Research & Therapy, 2020 Background Machado-Joseph disease is the most common autosomal dominant hereditary ataxia worldwide without effective treatment. Mesenchymal stem cells (MSCs) could slow the disease progression, but side effects limited their clinical application ...
Hua-Jing You +11 more
doaj +2 more sources
Machado Joseph disease severity is linked with gut microbiota alterations in transgenic mice
Neurobiology of Disease, 2023 Emerging evidence suggests the presence of bidirectional interactions between the central nervous system and gut microbiota that may contribute to the pathogenesis of neurodegenerative diseases.
Hasinika K.A.H. Gamage +4 more
doaj +2 more sources
State biomarkers for Machado Joseph disease: Validation, feasibility and responsiveness to change [PDF]
Genetics and Molecular Biology, 2019 Machado-Joseph disease (SCA3/MJD) is the most common spinocerebellar ataxia worldwide, and particularly so in Southern Brazil. Due to an expanded polyglutamine at ataxin-3, SCA3/MJD presents a relentless course with no current disease modifying treatment.
Gabriel Vasata Furtado +5 more
doaj +2 more sources
Sentinel Node Biopsy and Lumpectomy in a Patient with Machado–Joseph Disease [PDF]
Case Reports in Anesthesiology, 2019 Spinocerebellar ataxia 3 (SCA3), also known as Machado–Joseph disease (MJD) is an autosomal dominant, progressive neurodegenerative disorder. Patients present with cerebellar ataxia, dystonia, rigidity, and neuropathy that worsen with time.
N. N. Aldawoodi +3 more
doaj +2 more sources
T2-hyperintensity in the internal globus pallidus in Machado-Joseph disease [PDF]
Arquivos de Neuro-Psiquiatria, 2023 Alex T. Meira +6 more
doaj +2 more sources
Extracellular vesicles-associated AAVs for the treatment of Machado-Joseph disease. [PDF]
Mol TherHenriques C +21 more
europepmc +3 more sources