Results 41 to 50 of about 5,061 (184)

Neuropeptide Y (NPY) as a therapeutic target for neurodegenerative diseases

Neurobiology of Disease, 2016
Neuropeptide Y (NPY) and NPY receptors are widely expressed in the mammalian central nervous system. Studies in both humans and rodent models revealed that brain NPY levels are altered in some neurodegenerative disorders, such as Alzheimer's disease ...
Joana Duarte-Neves, Luís Pereira de Almeida, Cláudia Cavadas   +2 more
doaj   +1 more source

Generation of an integration-free induced pluripotent stem cell (iPSC) line (ZZUNEUi002-A) from a patient with spinocerebellar ataxia type 3

Stem Cell Research, 2020
Using a non-integrative reprogramming method, a human iPSC Line, ZZUNEUi002-A, was generated from a 22-year-old male patient with spinocerebellar ataxia type 3 /Machado-Joseph disease (SCA3/MJD).
Liting Wei, Jwei Zhang, Dingbang Chen, Li Feng, Chao Wu, Rui Wang, Xunhua Li   +6 more
doaj   +1 more source

Reconstructing the History of Machado-Joseph Disease [PDF]

European Neurology, 2020
Machado-Joseph disease (MJD), or spinocerebellar ataxia type 3, was originally described in members of the families of Machado, Thomas, and Joseph from São Miguel Island, Azores, Portugal, in 1972. The purpose of this article is to present previous descriptions of hereditary ataxia resembling the heterogeneous phenotypic intra-familiar presentation of ...
Alex Tiburtino Meira, José Luiz Pedroso, François Boller, Gustavo Leite Franklin, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive   +5 more
openaire   +2 more sources

SUMO-1 modification on K166 of polyQ-expanded ataxin-3 strengthens its stability and increases its cytotoxicity. [PDF]

PLoS ONE, 2013
Post-translational modification by SUMO was proposed to modulate the pathogenesis of several neurodegenerative diseases. Spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) is an autosomal dominant neurodegenerative disease caused by polyQ ...
Ya-Fang Zhou, Shu-Sheng Liao, Ying-Ying Luo, Jian-Guang Tang, Jun-Ling Wang, Li-Fang Lei, Jing-Wei Chi, Juan Du, Hong Jiang, Kun Xia, Bei-Sha Tang, Lu Shen   +11 more
doaj   +1 more source

Assessment of Bone Mineral Density of Patients with Spinocerebellar Ataxia Type 3 [PDF]

Journal of Movement Disorders, 2019
Objective Machado-Joseph disease (MJD) is a spinocerebellar ataxia, and osteoporosis is a multifactor disease that may affect patients with neurologic conditions. The frequency of osteoporosis among MJD patients, however, has not been studied.
Aline MS Farias, Simone Appenzeller, Marcondes C França, Alberto RM Martinez, Elba E Etchebehere, Thiago F Souza, Allan O Santos   +6 more
doaj   +1 more source

Inflammation‐related proteomic changes in response to amyloid and tau pathologies

Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.
Abstract Background Emerging evidence underscores the importance of neuroinflammation in the progression of Alzheimer's disease (AD) pathophysiology. Recent studies indicate the involvement of inflammatory mechanisms in amyloid‐β (Aβ) and tau deposition in the brain.
Ilaria Pola, Nicholas J. Ashton, Marco Antônio De Bastiani, Luiza Santos Machado, Guilherme Povala, Wagner S. Brum, Nesrine Rahmouni, Kübra Tan, Marisa N. Denkinger, Stijn Servaes, Joseph Therriault, Tharick A Pascoal, Kaj Blennow, Henrik Zetterberg, Eduardo R. Zimmer, Pedro Rosa‐Neto, Andrea L. Benedet   +16 more
wiley   +2 more sources

Redox environment modulates aggregation of ataxin‐3 in vitro — Implications for drug screening of cysteine‐rich proteins

The FEBS Journal, EarlyView.
Redox environment modulates in vitro aggregation of Ataxin‐3, the protein implicated in spinocerebellar ataxia type 3. Reducing conditions stabilize native monomers and prevent aggregation, whereas oxidative conditions promote the formation of non‐native conformers and disulfide‐linked oligomers within the Josephin domain (JD).
Martyna Podlasiak, Martina Sollazzo, Elisa Monaca, Raffaele Sabbatella, Maria Agnese Morando, Oleg Chertkov, Laura Puglisi, Martina Mascellino, Anna Fricano, Sandra Macedo‐Ribeiro, Caterina Alfano   +10 more
wiley   +1 more source

Machado-Joseph Disease: from first descriptions to new perspectives

Orphanet Journal of Rare Diseases, 2011
Machado-Joseph Disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3), represents the most common form of SCA worldwide. MJD is an autosomal dominant neurodegenerative disorder of late onset, involving predominantly the cerebellar, pyramidal ...
Bettencourt Conceição, Lima Manuela
doaj   +1 more source

Development and Psychometric Evaluation of the Forensic Nursing Competency Scale‐Short Form for Hospital Nurses

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To develop and evaluate the psychometric properties of the Forensic Nursing Competency Scale‐Short Form (FNCS‐SF) for hospital nurses. Background Nurses who care for victims of sexual abuse, domestic violence and elder or child abuse require forensic nursing competencies.
Youn‐Jung Son, Na Young Jo, Yun Mi Lee, So Hyun Park   +3 more
wiley   +1 more source

Generation of an induced pluripotent stem cell line (XHCSUi001-A) from urine cells of a patient with spinocerebellar ataxia type 3

Stem Cell Research, 2019
The induced pluripotent stem cell (iPSC) line XHCSUi001-A generated from urine cells of a female spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) patient by using the integration-free methods.
Lang He, Wei Ye, Zhao Chen, Chunrong Wang, Huifang Zhao, Shuai Li, Linliu Peng, Xiaobo Han, Tiancheng Zhou, Zhiyuan Li, Beisha Tang, Hong Jiang   +11 more
doaj   +1 more source