Results 51 to 60 of about 6,842,995 (191)

SUMO-1 modification on K166 of polyQ-expanded ataxin-3 strengthens its stability and increases its cytotoxicity. [PDF]

PLoS ONE, 2013
Post-translational modification by SUMO was proposed to modulate the pathogenesis of several neurodegenerative diseases. Spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) is an autosomal dominant neurodegenerative disease caused by polyQ ...
Ya-Fang Zhou, Shu-Sheng Liao, Ying-Ying Luo, Jian-Guang Tang, Jun-Ling Wang, Li-Fang Lei, Jing-Wei Chi, Juan Du, Hong Jiang, Kun Xia, Bei-Sha Tang, Lu Shen   +11 more
doaj   +1 more source

Expanded ATXN3 CAG Repeat is Stable in Human Purkinje Cells

Movement Disorders, EarlyView.
Abstract Background Spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disorder caused by an abnormally long polyglutamine‐encoding CAG repeat in the ATXN3 gene. Objectives We aimed to determine whether somatic expansion of the mutant ATXN3 (mATXN3) CAG repeat is present in the output cell of the cerebellar cortex, the Purkinje cell (PC), in ...
Hasnahana Chetia, Laura Kus, Erika Sipos, Nathaniel Heintz, Kert Mätlik   +4 more
wiley   +1 more source

The Impact of Common Medications on Male Fertility: An Updated Systematic Review

Andrology, EarlyView.
ABSTRACT Background Compared with those of cytotoxic treatments, the potential effects of common medications on the fertility of men trying to conceive currently or planning to conceive in the future are less well described. The use of common medications may modify the gonadotropic axis, spermatogenesis, and epididymal maturation or alter male ...
Lina Jebli, Salomé Gallissian, Roxanne Barèges, Félicia Fournier, Catherine Metzler‐Guillemain, Ségolène Prades, Fanny Magnan‐Sebag, Jeanne Perrin   +7 more
wiley   +1 more source

Assessment of Bone Mineral Density of Patients with Spinocerebellar Ataxia Type 3 [PDF]

Journal of Movement Disorders, 2019
Objective Machado-Joseph disease (MJD) is a spinocerebellar ataxia, and osteoporosis is a multifactor disease that may affect patients with neurologic conditions. The frequency of osteoporosis among MJD patients, however, has not been studied.
Aline MS Farias, Simone Appenzeller, Marcondes C França, Alberto RM Martinez, Elba E Etchebehere, Thiago F Souza, Allan O Santos   +6 more
doaj   +1 more source

Thermophysiological and perceptual responses to exercise heat stress in people with cystic fibrosis on Elexacaftor/Tezacaftor/Ivacaftor

Experimental Physiology, EarlyView.
Abstract The objective of this study was to investigate thermophysiological and perceptual responses to exercise heat stress in people with cystic fibrosis (pwCF) on Elexacaftor/Tezacaftor/Ivacaftor (ETI) versus healthy controls, and to explore their lived experiences of heat stress.
Lauren J. Clayton, Jo Corbett, Anthony I. Shepherd, Heather Massey, Don S. Urquhart, Neil Maxwell, Gary Connett, Mark Allenby, Julian Legg, Thomas Daniels, Zoe L. Saynor   +10 more
wiley   +1 more source

Persistent endothelial dysfunction is associated with exercise intolerance in adults despite preserved myocardial work 3 years after SARS‐CoV‐2 infection

Physiological Reports, Volume 14, Issue 19, October 2026.
Adults with Long COVID exhibited impaired aerobic capacity and persistent endothelial dysfunction despite preserved myocardial function approximately 3 years after SARS‐CoV‐2 infection. The association between flow‐mediated dilation (FMD) and exercise capacity suggests a potential contribution of peripheral vascular dysfunction to exercise intolerance.
Carla Cristina de Araújo Alves, Cássia da Luz Goulart, Luciana D'Ávila, Beatriz Helena Ernesto de Souza Silva, Igor Machado Alves, Brena Vitória Souza Aguiar, Claudia Conde, Ricardo Stein, Gerson Cipriano Jr.   +8 more
wiley   +1 more source

Machado-Joseph Disease: from first descriptions to new perspectives

Orphanet Journal of Rare Diseases, 2011
Machado-Joseph Disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3), represents the most common form of SCA worldwide. MJD is an autosomal dominant neurodegenerative disorder of late onset, involving predominantly the cerebellar, pyramidal ...
Bettencourt Conceição, Lima Manuela
doaj   +1 more source

Availability of Cancer Screening Across HIV Treatment Sites in the IeDEA Consortium

International Journal of Cancer, Volume 159, Issue 6, Page 1477-1489, 15 September 2026.
In recent years, incorporating comprehensive cancer screening strategies into routine HIV care has gained growing attention. This survey of 220 sites providing HIV care across 41 countries shows that cervical cancer screening has increased in availability over time.
Rachael A. Pellegrino, Bryan E. Shepherd, Sanjay Pujari, Valeria Fink, Gad Murenzi, Miriam Nakalembe, Sally B. Coburn, Eliane Rohner, Antoine Jaquet, Caroline Lade, Brenda Crabtree Ramirez, Kathryn Anastos, Aggrey Semeere, Lesley S. Park, Limpho Mokone, Simon Boni, I Ketut Agus Somia, Emilia M. Jalil, Adebola Adedimeji, Omenge Orang'o, Michael J. Silverberg, Kumbirai Pise Quarter, Eugène Messou, Jeremy Ross, Eduardo Gotuzzo, Patricia Lelo, Helen Byakwaga, Oliver Ezechi, Jonathan Euvrard, Fernanda Maruri, Chad J. Achenbach, Jessica L. Castilho, on behalf of International epidemiology Databases to Evaluate AIDS (IeDEA)   +32 more
wiley   +1 more source

Generation of an induced pluripotent stem cell line (XHCSUi001-A) from urine cells of a patient with spinocerebellar ataxia type 3

Stem Cell Research, 2019
The induced pluripotent stem cell (iPSC) line XHCSUi001-A generated from urine cells of a female spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) patient by using the integration-free methods.
Lang He, Wei Ye, Zhao Chen, Chunrong Wang, Huifang Zhao, Shuai Li, Linliu Peng, Xiaobo Han, Tiancheng Zhou, Zhiyuan Li, Beisha Tang, Hong Jiang   +11 more
doaj   +1 more source

Mechanistic role of biochar as a geobiochemical amendment: Mitigating abiotic stress and enhancing soil–plant interactions

Soil Science Society of America Journal, Volume 90, Issue 5, September/October 2026.
Abstract Abiotic stressors, including drought, salinity, and heavy metal contamination, pose escalating threats to global food security, challenges further exacerbated by climate change and progressive soil degradation. As a strategic geochemical amendment, biochar is increasingly proposed to enhance soil resilience and agricultural sustainability ...
Waqas Haider, Qudrat Ullah, Muhammad Qasim, Md. Nahid Mahmud, Irfan Haidri, Muhammad Ali Amir, Rashid Abbas Khan, Tauqeer Ahmed Qadri, Amjid Khan   +8 more
wiley   +1 more source