Results 51 to 60 of about 4,259 (123)
Journal of the World Aquaculture Society, Volume 57, Issue 2, April 2026.Abstract This study evaluated the effects of dietary supplementation with ALLPRO, a source of docosahexaenoic acid (DHA—C22:6n‐3, 126 g kg−1 dry weight) and nucleotides (5 g kg−1 dry weight), on Nile tilapia farmed in southern Brazil during autumn, winter, and spring.
Vitor Mendes Lehmkuhl +6 more
wiley +1 more source
Brain stem and cerebellum volumetric analysis of Machado Joseph disease patients
Arquivos de Neuro-Psiquiatria, 2011 Machado-Joseph disease, or spinocerebellar ataxia type 3(MJD/SCA3), is the most frequent late onset spinocerebellar ataxia and results from a CAG repeat expansion in the ataxin-3 gene. Previous studies have found correlation between atrophy of cerebellum
S T Camargos, W Marques-Jr, A C Santos
doaj +1 more source
Arquivos de Neuro-Psiquiatria, 2004 As enfermidades heredo-degenerativas, entre elas as ataxias cerebelares autossômicas dominantes, agora conhecidas como ataxias espinocerebelares (AEC), correspondem a extenso grupo de s com grande heterogeneidade genética.
Hélio A. Ghizoni Teive +1 more
doaj +1 more source
Veterinary Medicine and Science, Volume 12, Issue 2, March 2026.ABSTRACT Background: Orf virus (ORFV), a zoonotic member of the genus Parapoxvirus, causes contagious ecthyma in sheep and goats and poses significant economic and public health concerns. Despite frequent outbreaks, molecular data on ORFV circulating in Tanzania remain scarce.
Charles Mayenga +4 more
wiley +1 more source
Advanced Science, Volume 13, Issue 11, 23 February 2026.This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva +28 more
wiley +1 more source
USP10 in Neurological Disorders: Mechanistic Insights and Emerging Therapeutic Strategies
Annals of the New York Academy of Sciences, Volume 1556, Issue 1, February 2026.USP10 is a deubiquitinating enzyme that affects neurological diseases through multiple mechanisms, including the accumulation of toxic proteins, autophagy, and immune responses. In this review, we discuss the structure and characteristics of USP10 and summarize the role of USP10 in neurological disorders.
Celemuge +5 more
wiley +1 more source
Physiotherapy Research International, Volume 31, Issue 1, January 2026.ABSTRACT Background and Purpose Spinocerebellar ataxia (SCA) is a progressive neurodegenerative disorder characterized by impaired postural control, coordination deficits, and functional limitations. Despite evidence supporting physiotherapy interventions, standardized rehabilitation protocols remain scarce.
Luiz Humberto Figueiredo Monteiro +5 more
wiley +1 more source
Parkinsonian phenotype in Machado-Joseph disease (MJD/SCA3): a two-case report
BMC Neurology, 2011 Background Machado-Joseph disease (MJD), or spinocerebellar ataxia type 3 (SCA3), is an autosomal dominant neurodegenerative disorder of late onset, which is caused by a CAG repeat expansion in the coding region of the ATXN3 gene.
Vasconcelos João +9 more
doaj +1 more source
Peripheral Oxidative Stress Biomarkers in Spinocerebellar Ataxia Type 3/Machado–Joseph Disease
Frontiers in Neurology, 2017 ObjectivesSpinocerebellar ataxia type 3/Machado–Joseph disease (SCA3/MJD) is a polyglutamine disorder with no current disease-modifying treatment. Conformational changes in mutant ataxin-3 trigger different pathogenic cascades, including reactive oxygen ...
Adriano M. de Assis +39 more
doaj +1 more source