Results 121 to 130 of about 4,445 (267)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Microstructure-Machinability correlation in heat treated AISI 1040 steel: Comparative analysis of tool life and surface roughness. [PDF]

PLoS One
Poojary UR, Hegde A, Hegde S, Mahale RS.
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

High-density Binderless Bamboo Brush Handles via High-consistency Mechano-enzymatic Pretreatment: Micro-filler Effect and Machinability

BioResources
The resurgence of traditional culture has driven market demand for high-quality writing brushes. Natural bamboo frequently suffers from hygroscopic cracking, whereas polymer substitutes face the dual challenges of aesthetic deficiency and formaldehyde ...
Zheng Xue, Chen Hang
doaj  

Machinability enhancement of heat-treated Incoloy 800H during turning using laser-textured carbide inserts under semi-solid MoS₂ lubrication. [PDF]

PLoS One
Angappan P, Duraisamy P, Chellamuthu P, Agarwal A, Kasirajan L.   +4 more
europepmc   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Machining performance investigation on 17-4PH steel material with innovative textured tools. [PDF]

Sci Rep
Sivaiah P, Rao KMC, Yuvaraj C, Mallikarjuna P, Reddy VC, Nishkala T.   +5 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Sustainable optimization of drilling performance in Al6061-B₄C composites: process-property interactions for lightweight engineering applications. [PDF]

Sci Rep
Nithyananda BS, Jain SP, Chethan KN, Kini CR.   +3 more
europepmc   +1 more source