Results 111 to 120 of about 15,103 (307)
Medžiagotyra, 2019 A co-continuous ceramic composite (C4) was manufactured by gravity infiltration. The effect of varying machining parameters namely, speed, feed and depth of cut during end milling of C4, on the multi-responses of surface roughness, tool wear and depth of
Prasanth ACHUTHAMENON SYLAJAKUMARI +3 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
The machinability of nickel-based alloys in high-pressure jet assisted (HPJA) turning
Metalurgija, 2013 Due to their mechanical, thermal and chemical properties, nickel-based alloys are generally included among materials that are hard to machine. An experimental study has been performed to investigate the capabilities of conventional and high-pressure jet ...
D. Kramar +3 more
doaj
Технічна інженеріяIn modern aircraft engine manufacturing, titanium alloys are an indispensable material for the production of the most critical and highly loaded rotor components of gas turbine engines, such as integrally bladed rotors (blisks) and compressor discs.
I.A. Boiko
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Point defect engineering and machinability in n-type Mg3Sb2-based materials
, 2020 Approaching practical thermoelectric devices require high-performance and machinable thermoelectric materials. However, the currently available materials are usually brittle.
Jia, Fei +9 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Evaluating Product Machinability for Concurrent Engineering
, 1992 Decisions made during the design of a machined part can significantly affect the product's cost, quality, and lead time. Thus, in order to address the goals of concurrent engineering, it is important to evaluate the machinability of the proposed design ...
Karinthi, Raghu R. +3 more
core +2 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source