Results 81 to 90 of about 1,135,266 (267)

Ethical and Cognitive Impacts of Machine Learning in Education: A Stakeholder-Centric Analysis

Sanskriti
This study explores machine learning (ML) in education, focusing on its effects on creativity, critical thinking, and a human-centeredapproach to learning.
Dr.Busayo Ajayi, Adu Emmanuel Ifedayo
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Preoperative Prediction of Intraoperative Transfusion in Pediatric Craniosynostosis Surgery: An Exploratory Prediction Model Study

Medicina
Background and Objectives: Craniosynostosis repair is associated with a high perioperative transfusion rate, but preoperative prediction models remain limited.
Sung-Hye Byun, Jihyun Woo, Jung A Lim, Sou-Hyun Lee   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Machine consciousness

Scholarpedia, 2005
The work from several laboratories on the modeling of consciousness is reviewed. This ranges, on one hand, from purely functional models where behavior is important and leads to an attribution of consciousness to, on the other hand, material work closely derived from the information about the anatomy of the brain. At the functional end of the spectrum,
openaire   +2 more sources

Advancing the Engineering Approach to Improving the Quality Cracking Efficiency of Palm Nut Crackiing Machine

Turkish Journal of Agriculture: Food Science and Technology
A Palm Nut cracking machine with an improved beater configuration was developed to effectively crack Palm Nuts of various species and sizes. This research aim at improving the quality of the Palm kernel recovered at relatively low cost during Palm kernel
Okunola Oluwatobi Israel, Olukunle Olawale John, Adetola Oluwafemi Adeyemi, Akinfiresoye Waleola   +3 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Giry and the Machine

Electronic Notes in Theoretical Computer Science, 2016
AbstractWe present a general method – the Machine – to analyse and characterise in finitary terms natural transformations between well-known functors in the category Pol of Polish spaces. The method relies on a detailed analysis of the structure of Pol and a small set of categorical conditions on the domain and codomain functors.
Fredrik Dahlqvist, Vincent Danos, Ilias Garnier   +2 more
openaire   +3 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source