Results 71 to 80 of about 1,135,266 (267)
EXTENDED TECHNICAL INSPECTION FOR PATH OF ROLLING FROM M5A COAL REMOVAL MACHINE [PDF]
Journal of Research and Innovation for Sustainable Society, 2020 This path of rolling is carried out on longitudinal ties of reinforced concrete and is formed from the superstructure 49 by 15 m length, fixed to the metal plates 49 with the clamping indirect type.The way of rolling has 680 m of which is operated on a
Alin STĂNCIOIU
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Metaphysical Primitives: Machines and Assemblages in Deleuze, DeLanda, and Bryant
Open Philosophy, 2020 Some variants of Object-Oriented Ontology define entities in terms of their powers. Such variants are rooted in Gilles Deleuze and Félix Guattari’s theory of “machinic assemblages”.
Kleinherenbrink Arjen
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Projet d'une philosophie extra-ordinaire
Methodos, 2010 The aim of this paper is to discuss a philosophical method based on narrative fiction. I attempt to make systematic, and to give a foundation to, the use of narrative fictions in philosophy.
Pierre Cassou-Noguès
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Frontiers in Bioengineering and Biotechnology, 2014 There’s a time to be born, and a time to die; a time to break down, and a time to build up; a time to weep, and a time to laugh; a time to keep silence, and a time to speak… (Ecclesiastes 3, 2-7). There was a time when automata were designed like clocks.
Danilo Emilio De Rossi +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
CoRR, 2020 Molecular robotics is challenging, so it seems best to keep it simple. We consider an abstract molecular robotics model based on simple folding instructions that execute asynchronously. Turning Machines are a simple 1D to 2D folding model, also easily generalisable to 2D to 3D folding. A Turning Machine starts out as a line of connected monomers in the
Irina Kostitsyna, Cai Wood, Damien Woods
openaire +4 more sources