Results 81 to 90 of about 721,808 (317)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
High Voltage, 2019 The large current generated by a direct start of the super-large-capacity high-voltage induction motor would have a huge impact on the power grid as well as the motor itself.
Jiaxin Yuan +5 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
The Journal of Engineering, 2019 Considering the internal and external disturbances of the direct-driven wind energy conversion systems, i.e. multi-variable coupling, non-linear characteristic and modelling error, and the environmental disturbances, an adaptive sliding mode observer ...
Siyue Wang +4 more
doaj +1 more source
Sensored and sensorless speed control methods for brushless doubly fed reluctance motors
, 2009 The study considers aspects of scalar V/f control, vector control and direct torque (and flux) control (DTC) of the brushless doubly fed reluctance machine (BDFRM) as a promising cost-effective alternative to the existing technological solutions for ...
Jovanovic, Milutin
core +1 more source
Induction machine fault detection enhancement using a stator current high resolution spectrum [PDF]
, 2012 Fault detection in squirrel cage induction machines based on stator current spectrum has been widely investigated. Several high resolution spectral estimation techniques have been developed and used to detect induction machine abnormal operating ...
CHARPENTIER, Jean-Frederic +8 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Design of torque system for electric bicycle based on fuzzy PID
The Journal of Engineering, 2019 This article analyses the structure and working principle of the brushless DC motor, the advantages and disadvantages of PID regulation and fuzzy control are analysed as well, and puts forward the fuzzy PID motor control technology with both advantages ...
Yunhong Zheng +2 more
doaj +1 more source
Flux Weakening Strategy Optimization for Five-Phase PM Machine with Concentrated Windings [PDF]
, 2012 The paper applies an Efficient Global Optimization method (EGO) to improve the efficiency, in flux weakening region, of a given 5-phase Permanent Magnet (PM) machine. An optimal control for the four independent currents is thus defined.
JILIN, Gong +3 more
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source