Results 71 to 80 of about 721,808 (317)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
The Journal of Engineering, 2019 This study proposes several easy-to-implement control strategies when seven-phase axial flux brushless DC machines with trapezoidal back electromotive forces operate in normal and faulty modes by taking into account constraints on voltage and current ...
Duc Tan Vu +3 more
doaj +1 more source
The Journal of Engineering, 2019 Providing additional damping for system electromechanical oscillations through doubly fed induction generator (DFIG)-based wind turbines is investigated in this study.
Mohammad Jafarian, Mohammad-Naser Asefi
doaj +1 more source
Statistical analysis of alignment characteristics for phrase-based machine translation [PDF]
, 2010 In most statistical machine translation (SMT) systems, bilingual segments are extracted via word alignment. However, there lacks systematic study as to what alignment characteristics can benefit MT under specific experimental settings such as the ...
Petitrenaud, Simon +7 more
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
The Journal of Engineering, 2019 A technique for driving a star-connected PMSM without a position or speed sensor, which is known in the literature as Direct Flux Control (DFC), is described here.
Klaus Schuhmacher +2 more
doaj +1 more source
Abstract Machines, Control, and Sequents [PDF]
, 2002 We describe simple call-by-value and call-by-name abstract machines, expressed with the help of Felleisen's evaluation contexts, for a toy functional language. Then we add a simple control operator and extend the abstract machines accordingly. We give some examples of their use.
openaire +1 more source