We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Quantum machines with classical control
Herein we survey the main results concerning quantum automata and machines with classical control. These machines were originally proposed by Sernadas et al in [37], during the FCT QuantLog project. First, we focus on the expressivity of quantum automata with both quantum and classical states.
Paulo Mateus, Daowen Qiu, Andre Souto
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Theoretical analysis of control properties for the brushless doubly fed reluctance machine
Presents the fundamental theory, modelling aspects and operating/control principles of the BDFRM. This emerging machine technology is being regarded by academic and industrial communities as a prospective brushless candidate for wind turbine generators ...
Betz, Robert +3 more
core +1 more source
An Efficient Control of a Series Connected Two-Synchronous Motor 5-Phase with Non Sinusoidal EMF Supplied by a Single 5-leg VSI: Experimental and Theoretical Investigations [PDF]
Lien vers la version finale éditeur This paper proposes the control scheme of an original drive which is made up of two 5-phase permanent magnet synchronous machines (PMSM) connected in series.
CHARPENTIER, Jean-Frederic +3 more
core +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Automatic Optical Path Alignment Method for Optical Biological Microscope
A high-quality optical path alignment is essential for achieving superior image quality in optical biological microscope (OBM) systems. The traditional automatic alignment methods for OBMs rely heavily on complex masker-detection techniques.
Guojin Peng +4 more
doaj +1 more source
Fast and Simple Tuning Rules of Synchronous Reference Frame Proportional-Integral Current Controller
Synchronous reference frame proportional-integral (PI) current controller (CC) is considered the most well-established solution for the current regulation in electrical drives.
Ahmed M. Diab +8 more
doaj +1 more source
Intermittent Control in Man and Machine [PDF]
Intermittent control has a long history in the physiological literature and there is strong experimental evidence that some human control systems are intermittent. Intermittent control has also appeared in various forms in the engineering literature.
Peter J. Gawthrop +2 more
openaire +2 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source

