Results 41 to 50 of about 11,508,248 (248)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Existence, Uniqueness, and Continuous Dependence on Initial/Final Values for Liouville–Caputo Fractional Difference Equations

Fractal and Fractional
This paper develops a unified qualitative framework for four classes of Liouville–Caputo fractional difference equations arising from different combinations of fractional sums and integer-order differences.
Xiaomin Li, Huaigu Tian, Peijun Zhang, Xin Liu   +3 more
doaj   +1 more source

Fast and Simple Tuning Rules of Synchronous Reference Frame Proportional-Integral Current Controller

IEEE Access, 2021
Synchronous reference frame proportional-integral (PI) current controller (CC) is considered the most well-established solution for the current regulation in electrical drives.
Ahmed M. Diab, Serhiy Bozhko, Feng Guo, Mohamed Rashed, Giampaolo Buticchi, Zhuang Xu, Seang Shen Yeoh, Chris Gerada, Michael Galea   +8 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Automatic Optical Path Alignment Method for Optical Biological Microscope

Sensors
A high-quality optical path alignment is essential for achieving superior image quality in optical biological microscope (OBM) systems. The traditional automatic alignment methods for OBMs rely heavily on complex masker-detection techniques.
Guojin Peng, Zhenming Yu, Xinjian Zhou, Guangyao Pang, Kuikui Wang   +4 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

A Cost-Effective and Flexible Decision-Making Method for Multi-Objective Finite Control Set Model Predictive Control

IEEE Access
Multi-objective finite control set-model predictive control (FCS-MPC) plays a prominent role in controlling modern power converters and electric drives.
Emrah Zerdali, Jacopo Riccio, Jakson Bonaldo, Marco Rivera, Pat Wheeler, Michele Degano   +5 more
doaj   +1 more source

Development of a wind turbine simulator

The Journal of Engineering, 2019
As a renewable energy source, wind power has become a hot research topic, despite the lack of wind-environment simulation equipment in most laboratories.
Yuan Sun, Ji Zhang, Yanru Zhou
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source