Results 101 to 110 of about 1,297,449 (284)

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Work Roll Cooling System Design Optimisation in Presence of Uncertainty [PDF]

, 2009
Organised by: Cranfield UniversityThe paper presents a framework to optimise the design of work roll based on the cooling performance. The framework develops Meta models from a set of Finite Element Analysis (FEA) of the roll cooling.
Azene, Y. T., Farrugia, Didier, Mehnen, Jorn, Onisa, C., Roy, Rajkumar, Trautmann, H.   +5 more
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Co-Simulation of an Inverter Fed Permanent Magnet Synchronous Machine

Electrical, Control and Communication Engineering, 2014
Co-simulation is a method which makes it possible to study the electric machine and its drive at once, as one system. By taking into account the actual inverter voltage waveforms in a finite element model instead of using only the fundamental, we are ...
Kiss Gergely Máté, Vajda István
doaj   +1 more source

Parallel processors and nonlinear structural dynamics algorithms and software [PDF]

The adaptation of a finite element program with explicit time integration to a massively parallel SIMD (single instruction multiple data) computer, the CONNECTION Machine is described.
Belytschko, Ted, Gilbertsen, Noreen D., Neal, Mark O., Plaskacz, Edward J.   +3 more
core   +1 more source

Computer-Aided Conceptual Design Through TRIZ-based Manipulation of Topological Optimizations [PDF]

, 2009
Organised by: Cranfield UniversityIn a recent project the authors proposed the adoption of Optimization Systems [1] as a bridging element between Computer-Aided Innovation (CAI) and PLM to identify geometrical contradictions [2], a particular case of ...
Cascini, G., Cugini, U., Frillici, F. S., Rotini, F.   +3 more
core  

A simple atomic beam oven with a metal thermal break

, 2018
We report the design and construction of a simple, easy to machine high-temperature oven for generating an atomic beam in laser cooling experiments. This design eliminates the problem of thermal isolation of the oven region from the rest of the vacuum ...
Mangaonkar, Jay, Patel, Kushal, Rapol, Umakant D., Sarkar, Sumit, Verma, Gunjan, Vishwakarma, Chetan   +5 more
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

On the feasibility of monitoring DTN: Impacts of fine tuning on routing protocols and the user experience [PDF]

, 2012
The “machine to machine” communication paradigm will become a central element for mobile networks. This paradigm can be easily constructed by a contact-based network, notably a disruption/delay tolerant networks (DTN).
Lochin, Emmanuel, Rakotoarivelo, Thierry, Ramiro, Victor, Sénac, Patrick   +3 more
core  

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source