Results 101 to 110 of about 189,037 (316)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Comparative analysis of salient pole and flux barrier rotor for synchronous reluctance machines including flux weakening range

The Journal of Engineering, 2019
Here, synchronous reluctance machine types related to electrical traction applications are investigated including flux weakening range. A flux barrier (FB) machine with a carbon fibre-reinforced plastic bandage and a salient pole machine are designed by ...
Matthias Hofer, Mario Nikowitz, Mario Nikowitz, Manfred Schrödl   +3 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Evaluation and Comparison of a Large Machine Tool Structure with ISO Standard Alignment Tests

, 2009
In order to satisfactorily machine precision components it is necessary for machine tools to be able to achieve extremely high levels of geometric accuracy.
Longstaff, Andrew P., Myers, A., Barrans, Simon, Longstaff, A. P., Fletcher, Simon, Barrans, S. M., Fletcher, S., Ford, Derek G., Ford, D. G., Myers, Alan   +9 more
core  

Multi-step ahead direct prediction for machine condition prognosis using regression trees and neuro-fuzzy systems

, 2009
This paper presents an approach to predict the operating conditions of machine based on classification and regression trees (CART) and adaptive neuro-fuzzy inference system (ANFIS) in association with direct prediction strategy for multi-step ahead ...
Yang, Bo-Suk, Tan, Andy Chit Chiow, Tran, Van Tung   +2 more
core   +1 more source

Co-Simulation of an Inverter Fed Permanent Magnet Synchronous Machine

Electrical, Control and Communication Engineering, 2014
Co-simulation is a method which makes it possible to study the electric machine and its drive at once, as one system. By taking into account the actual inverter voltage waveforms in a finite element model instead of using only the fundamental, we are ...
Kiss Gergely Máté, Vajda István
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Theoretical analysis of control properties for the brushless doubly fed reluctance machine

, 2002
Presents the fundamental theory, modelling aspects and operating/control principles of the BDFRM. This emerging machine technology is being regarded by academic and industrial communities as a prospective brushless candidate for wind turbine generators ...
Betz, Robert, Jovanovic, Milutin, R.E. Betz, M.G. Jovanovic   +3 more
core   +1 more source

A new material model for 2D numerical simulation of serrated chip formation when machining titanium alloy Ti-6Al-4V [PDF]

, 2008
A new material constitutive law is implemented in a 2D finite element model to analyse the chip formation and shear localisation when machining titanium alloys. The numerical simulations use a commercial finite element software (FORGE 2005) able to solve
CALAMAZ, Madalina, GIROT, Franck, COUPARD, Dominique   +2 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source