Results 31 to 40 of about 3,579,627 (239)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Modelling and passive correction investigation of vibration induced machining errors on CNC machine tools [PDF]

Machine tool vibration is a complex subject requiring a multi-disciplinary approach involving the identification and analysis of the vibration sources and characteristics, as well as its direct and indirect effects. Machine tool vibration is influenced
Widiyarto, Muhammad Helmi Nur
core   +4 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Structural analysis and chracterisation technique applied to a CNC vertical machining centre [PDF]

, 2014
There is a requirement for improved 3D surface characterisation and reduced tool wear, when modern computer numerical-controlled (CNC) machine tools are operating at high cutting velocities, spindle speeds and feed-rates.
Widiyarto, Muhammad Helmi Nur, Longstaff, Andrew P., Fletcher, Simon, Ford, Derek G., Myers, Alan   +4 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Multi-step ahead direct prediction for machine condition prognosis using regression trees and neuro-fuzzy systems [PDF]

, 2009
This paper presents an approach to predict the operating conditions of machine based on classification and regression trees (CART) and adaptive neuro-fuzzy inference system (ANFIS) in association with direct prediction strategy for multi-step ahead ...
Yang, Bo-Suk, Tan, Andy Chit Chiow, Tran, Van Tung, Tran, Van, Tan, Andy   +4 more
core   +1 more source

Design of Machine Elements

Design of Machine Elements is a comprehensive textbook that provides an in-depth understanding of the principles, analysis, and design methodologies of mechanical machine components used in modern engineering applications. Structured to meet the academic requirements of undergraduate and postgraduate mechanical engineering programs, the book ...
Mr. R. Prem Kumar, Dr. S. Dineshkumar, Mr. Ganeshkumar KV   +2 more
  +6 more sources

Development of Intelligent Fault Diagnosis Technique of Rotary Machine Element Bearing: A Machine Learning Approach. [PDF]

Sensors (Basel), 2022
Saha DK, Hoque ME, Badihi H.
europepmc   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source