Results 101 to 110 of about 2,924,807 (328)

Whole-brain vasculature reconstruction at the single capillary level [PDF]

, 2018
The distinct organization of the brain’s vascular network ensures that it is adequately supplied with oxygen and nutrients. However, despite this fundamental role, a detailed reconstruction of the brain-wide vasculature at the capillary level remains ...
Allegra Mascaro, Anna Letizia, Costantini, Irene, Di Giovanna, Antonino Paolo, Frasconi, Paolo, Müllenbroich, Marie Caroline, Pavone, Francesco Saverio, Sacconi, Leonardo, Silvestri, Ludovico, Tibo, Alessandro   +8 more
core   +2 more sources

Genetic Modulation: Future Trends Toward Graft Optimization During Machine Perfusion

Transplantation, 2023
Dynamic preservation methods such as normothermic, subnormothermic, and hypothermic machine perfusion circuits have emerged as viable alternatives to conventional static cold storage.
Sabrina Stimmeder, B. Leber, R. Sucher, P. Stiegler   +3 more
semanticscholar   +1 more source

Spatial Patterning of Modular Gelatin‐Peroxide Microspheres in Melt‐Electrowritten Scaffolds Provides Controlled Oxygen Generation and Mitigates Hypoxia and Cytotoxicity

Advanced Healthcare Materials, EarlyView.
A bioassembly approach is described using photo‐crosslinked gelatin‐based microgels containing calcium peroxide (CaO2) to generate oxygen (O2) and enhance cell survival in hypoxic conditions (1% O2). Bioassembly enables spatial patterning of individual CaO2‐laden and mesenchymal stem cell (MSC)‐laden microgels and allows for decoupling and mitigating ...
Axel E. Norberg, F. Max Yavitt, Ezgi Bakirci, Khoon Lim, Tim B. F. Woodfield, Gabriella C. J. Lindberg   +5 more
wiley   +1 more source

Acellular Perfusate is an Adequate Alternative to Packed Red Blood Cells During Normothermic Human Kidney Perfusion

Transplantation Direct
Background. Brief normothermic machine perfusion is increasingly used to assess and recondition grafts before transplant. During normothermic machine perfusion, metabolic activity is typically maintained using red blood cell (RBC)–based solutions ...
Alban Longchamp, MD, PhD, Fermin M. Fontan, MD, Mohamed M. Aburawi, MD, Corey Eymard, MD, Negin Karimian, MD, PhD, Danielle Detelich, MD, Casie Pendexter, BS, Stephanie Cronin, MS, Thomas Agius, MS, Sonal Nagpal, MBA, Peony Dutta Banik, BS, Shannon N. Tessier, PhD, Sinan Ozer, MBA, Francis L. Delmonico, MD, Korkut Uygun, PhD, Heidi Yeh, MD, James F. Markmann, MD, PhD   +16 more
doaj   +1 more source

A microfluidic chip based model for the study of full thickness human intestinal tissue using dual flow [PDF]

, 2016
© 2016 Author(s). The study of inflammatory bowel disease, including Ulcerative Colitis and Crohn's Disease, has relied largely upon the use of animal or cell culture models; neither of which can represent all aspects of the human pathophysiology ...
A. Dawson, Ananthakrishnan A. N., C. Dyer, Itzkowitz S. H., J. Davies, J. Greenman, J. Macfie, L. Karsai, M. Jacobsen, Ponder A., Rodrigues E., Triantafillidis J. K.   +11 more
core   +1 more source

Graft repair during machine perfusion: a current overview of strategies

Current Opinion in Organ Transplantation
Purpose of review With changing donor characteristics (advanced age, obesity), an increase in the use of extended criteria donor (ECD) livers in liver transplantation is seen.
Roberto Broere, S. H. Luijmes, Jeroen de Jonge, Robert J. Porte   +3 more
semanticscholar   +1 more source

Smart Catheters for Diagnosis, Monitoring, and Therapy

Advanced Healthcare Materials, EarlyView.
This study presents a comprehensive review of smart catheters, an emerging class of medical devices that integrate embedded sensors, robotics, and communication systems, offering increased functionality and complexity to enable real‐time health monitoring, diagnostics, and treatment. Abstract This review explores smart catheters as an emerging class of
Azra Yaprak Tarman, Samiha Ahmed, Majed Othman Althumayri, Megan Guy, Darlenne Chavez Lugo, Frances S. Ligler, George T. Ligler, Rahmi Oklu, Hiroshi Kawahira, Michael J. McShane, Jun Kameoka, Jonathan Bova, Hatice Ceylan Koydemir   +12 more
wiley   +1 more source

Organ preservation: current limitations and optimization approaches

Frontiers in Medicine
Despite the annual rise in patients with end-stage diseases necessitating organ transplantation, the scarcity of high-quality grafts constrains the further development of transplantation.
Qiulin Ran, Jiayi Zhang, Jisheng Zhong, Ji Lin, Shuai Zhang, Guang Li, Bin You   +6 more
doaj   +1 more source

Reduction of Renal Preservation/Reperfusion Injury by Controlled Hyperthermia During Ex Vivo Machine Perfusion

Clinical and Translational Science, 2021
The possible reno‐protective effect of a controlled brief heat‐shock treatment during isolated ex vivo machine perfusion of donor grafts prior to reperfusion should be investigated in a primary in vitro study.
Thomas Minor, Charlotte vonHorn
doaj   +1 more source

Monitoring kidney optical properties during cold storage preservation with spatial frequency domain imaging. [PDF]

, 2019
Transplantation of kidneys results in delayed graft function in as many as 40% of cases. During the organ transplantation process, donor kidneys undergo a period of cold ischemic time (CIT), where the organ is preserved with a cold storage solution to ...
Durkin, Anthony, Ichii, Hirohito, Jarrin Lopez, Alberto, Li, Shiri, Li, Xiaodong, Ponticorvo, Adrien, Rowland, Rebecca   +6 more
core