Results 111 to 120 of about 2,924,807 (328)

Transplantation of discarded livers following viability testing with normothermic machine perfusion

Nature Communications, 2020
There is a limited access to liver transplantation, however, many organs are discarded based on subjective assessment only. Here we report the VITTAL clinical trial (ClinicalTrials.gov number NCT02740608) outcomes, using normothermic machine perfusion ...
H. Mergental, R. Laing, Amanda Kirkham, M. Perera, Y. Boteon, J. Attard, D. Barton, S. Curbishley, M. Wilkhu, D. Neil, Stefan G. Hübscher, P. Muiesan, J. Isaac, Keith J. Roberts, M. Abradelo, A. Schlegel, J. Ferguson, H. Cilliers, J. Bion, D. Adams, Chris Morris, P. Friend, C. Yap, S. Afford, Darius F. Mirza   +24 more
semanticscholar   +1 more source

Hybrid Scaffolds Decouple Biochemical & Biophysical Regulation of Cell Phenotype

Advanced Healthcare Materials, EarlyView.
Replicating tissue‐specific extracellular matrix is crucial for understanding its role in disease. This work demonstrates independent control over stiffness, composition and 3D collagen architecture using hybrid scaffolds: patterned collagen perfused with defined hydrogels.
Xinyuan Song, Samantha C. Mitchell, Abbie N. Smart, William Hardiman, Daniel V. Bax, Ceri E. Staley, Catherine Probert, Pamela Collier, Marian Meakin, Alison A. Ritchie, Tania Mendonca, Amanda J. Wright, Victoria James, Anna M. Grabowska, Catherine L. R. Merry, Serena M. Best, Ruth E. Cameron, Jennifer C. Ashworth   +17 more
wiley   +1 more source

Beating the reaction limits of biosensor sensitivity with dynamic tracking of single binding events [PDF]

, 2018
The clinical need for ultrasensitive molecular analysis has motivated the development of several endpoint-assay technologies capable of single-molecule readout.
Sevenler, Derin, Trueb, Jacob, Unlu, M. Selim   +2 more
core   +2 more sources

Human Brain Vasculature‐on‐a‐Chip Model Constructed With Microvessels Isolated From Cryopreserved Postmortem Human Brain Tissue

Advanced Healthcare Materials, EarlyView.
This manuscript describes the cultivation of viable microvessels from cryopreserved human brain tissue. When embedded in hydrogels and cultured in microfluidic devices, these microvessels exhibit complex architectures reminiscent of arterioles and capillaries, can be perfused, and display intact barrier function. Collectively, these results demonstrate
Brian J. O'Grady, A. Scott McCall, Samuel Cullison, Daniel Chavarria, Matthew S. Schrag, Ethan S. Lippmann   +5 more
wiley   +1 more source

Delivery of Multifunctional Microspheres via Intravesical Instillation for Bladder Carcinoma: Therapeutic Potential and Mechanistic Insights

Advanced Healthcare Materials, EarlyView.
PCTM microspheres were successfully synthesized using microfluidic and click chemistry techniques.In Vivo and in vitro experiments have shown that PCTM microspheres have obvious targeting, adhesion, membrane penetration and anti‐tumor properties for bladder tumors.The antitumor mechanism of PCTM microspheres is to indirectly induce S‐stage blockage of ...
Zhaoxiang Lu, Wentie Yang, Youzhi Hong, Yusen Qiao, Chaozhao Liang   +4 more
wiley   +1 more source

Bile proteome reveals biliary regeneration during normothermic preservation of human donor livers

Nature Communications, 2023
Normothermic machine perfusion (NMP) after static cold storage is increasingly used for preservation and assessment of human donor livers prior to transplantation.
Adam M. Thorne, Justina C. Wolters, Bianca Lascaris, Silke B. Bodewes, Veerle A. Lantinga, Otto B. van Leeuwen, Iris E. M. de Jong, Kirill Ustyantsev, Eugene Berezikov, Ton Lisman, Folkert Kuipers, Robert J. Porte, Vincent E. de Meijer   +12 more
doaj   +1 more source

International Veterinary Epilepsy Task Force recommendations for a veterinary epilepsy-specific MRI protocol [PDF]

, 2015
Epilepsy is one of the most common chronic neurological diseases in veterinary practice. Magnetic resonance imaging (MRI) is regarded as an important diagnostic test to reach the diagnosis of idiopathic epilepsy.
A Bathen-Noethen, A Ciantis De, A Pakozdy, AA Raymond, AJ Hall, AK Shah, Akos Pakozdy, AM McIntosh, Andrea Fischer, Andrea Tipold, AR Deibler, CJ Abramson, Clare Rusbridge, DK Thompson, E Wagner, Edward E. Patterson, EJ Ives, EL So, F Cendes, F Rosenow, GS Berns, GS Berns, H Goldberg, Heidrun Potschka, Holger A. Volk, I Craven, J Laothamatas, J Oertzen Von, J Velmurugan, J Wellmer, J Wellmer, Jacques Penderis, Jelena Jovanovik, JS Duncan, JW Wheless, K Ono, Karen Muñana, Kaspar Matiasek, KL Stadler, KM Casey, KM Fiest, L Gygax, L Heske, L Kearsley-Fleet, LM Mellema, LS Garosi, Luisa De Risio, M Guye, M Konar, M Schwartz, Marjorie Milne, ME Milne, Mette Berendt, Michael Podell, MJ Fernandes, MS Anaya Garcia, N Farid, N Ogata, NK Focke, O Jacqmot, P Singh, P Szmuk, PF Cook, PM Smith, PT Wei, R Goncalves, R Kuzniecky, R Neppl, R Vasta, R Viitmaa, R Viitmaa, RA Thames, RL Wolf, Robyn G. Farqhuar, S Hecht, S Mizoguchi, S Torisu, Sam Long, SD Shorvon, Simon Platt, Sofie F. M. Bhatti, SP Knowler, T Guadalupe, T Hammen, T Kuwabara, TJ Oertzen von, TS Jokinen, U Ebert, V Jantti, V Martle, Veronika M. Stein, WD Gaillard, YM Lim, YS Ding, Z Haneef   +94 more
core   +6 more sources

Bone Healing Around Implants in Normal and Medically Compromised Conditions: Osteoporosis and Diabetes

Advanced Healthcare Materials, EarlyView.
xx xx. ABSTRACT Osseointegration of orthopedic and dental implants is influenced by local and systemic factors, including their physicochemical surface properties and the patient's overall health status. Titanium and its alloys have been a longstanding standard for bone implants due to their innate biocompatibility and mechanical properties.
Dainelys Guadarrama Bello, Fabio Variola, Antonio Nanci   +2 more
wiley   +1 more source

Uterine Transplant Optimization From a Preclinical Donor Model With Controlled Cardiocirculatory Arrest

Transplantation Direct
Background. Uterus transplantation from deceased donors offers a promising solution to the organ shortage, but optimal preservation methods are crucial for successful outcomes. Our primary objective is to conduct an initial assessment of the contribution
Emma Loiseau, MSc, Benoit Mesnard, MSc, Sarah Bruneau, PhD, Carla De Sousa, MD, Stéphanie Bernardet, PhD, Jeremy Hervouet, David Minault, Stephan Levy, MSc, Antoine Le Gal, MD, Ludivine Dion, PhD, Gilles Blancho, MD, PhD, Vincent Lavoue, MD, PhD, Julien Branchereau, MD, PhD   +12 more
doaj   +1 more source

Novel translational approaches to the search for precision therapies for acute respiratory distress syndrome. [PDF]

, 2017
In the 50 years since acute respiratory distress syndrome (ARDS) was first described, substantial progress has been made in identifying the risk factors for and the pathogenic contributors to the syndrome and in characterising the protein expression ...
Calfee, Carolyn S, Meyer, Nuala J
core   +1 more source