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Machine perfusion of donor organs for transplantation
Artificial Organs, 2021AbstractThe ever‐widening gap between organ supply and demand has resulted in an organ shortage crisis that affects patients all over the world. For decades, static cold storage (SCS) was the gold standard preservation strategy because of its simplicity and cost‐effectiveness, but the rising unmet demand for donor organ transplants has prompted ...
Robert Tatum +3 more
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Myocardial perfusion characteristics during machine perfusion for heart transplantation
Surgery, 2008Optimal parameters for machine perfusion preservation of hearts prior to transplantation have not been determined. We sought to define regional myocardial perfusion characteristics of a machine perfusion device over a range of conditions in a large animal model.Dog hearts were connected to a perfusion device (LifeCradle, Organ Transport Systems, Inc ...
Matthias, Peltz +4 more
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Machine perfusion for cardiac allograft preservation
Current Opinion in Organ Transplantation, 2008The current cardiac preservation strategy for cardiac transplantation involves arresting hearts with a crystalloid preservation solution and storing them in this solution in an ice chest. This technique has allowed good results in heart transplantation, but has limited the transport interval, and has not encouraged major efforts to expand the donor ...
Michael L, Cobert +2 more
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Taking the Temperature on Machine Perfusion
Current Transplantation Reports, 2021Advances in machine perfusion technology have significantly improved organ utilization. However, consensus regarding the best dynamic preservation modality remains elusive. In this report, we evaluate recent results of clinical studies for different perfusion modalities and review new avenues of basic science aimed at organ rehabilitation.
Siavash Raigani, Heidi Yeh
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The role of machine perfusion in liver xenotransplantation
Current Opinion in Organ Transplantation, 2020Purpose of review To review the role of machine perfusion in advancing the study and clinical application of liver xenotransplantation to liver transplantation. Recent findings Recent multicenter trial has shown the benefits of normothermic machine perfusion (NMP) in the assessment ...
Malcolm, MacConmara +3 more
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2017
Transplant organ supplies are insufficient to meet the demands, resulting in prolonged patient wait times and waitlist mortality. Offering improved organ preservation, assessment, and resuscitation, machine perfusion of organs can enable the use of marginal organs, thereby expanding the donor pool.
Matthew F. Blum +7 more
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Transplant organ supplies are insufficient to meet the demands, resulting in prolonged patient wait times and waitlist mortality. Offering improved organ preservation, assessment, and resuscitation, machine perfusion of organs can enable the use of marginal organs, thereby expanding the donor pool.
Matthew F. Blum +7 more
openaire +1 more source
Normothermic Machine Perfusion of Kidneys: Optimization of Perfusate
2020Chronic kidney disease and end-stage renal disease (ESRD) are becoming increasingly prevalent in the world. The World Health Organization estimates that in 2015, 1.2 million people died from kidney failure, an increase of 32% from a decade ago. An estimated 2 million people worldwide are currently receiving lifesaving renal replacement therapy; however,
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Hypothermic machine perfusion in kidney transplantation
Current Opinion in Organ Transplantation, 2016This article summarizes novel developments in hypothermic machine perfusion (HMP) as an organ preservation modality for kidneys recovered from deceased donors.HMP has undergone a renaissance in recent years. This renewed interest has arisen parallel to a shift in paradigms; not only optimal preservation of an often marginal quality graft is required ...
De Deken, Julie +2 more
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Machine Perfusion in Liver Transplantation
Advances in Surgery, 2021Malcolm, MacConmara, Parsia A, Vagefi
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A Novel Machine Perfusion System for Enhancing Hepatic Microcirculation Perfusion
Artificial OrgansABSTRACTBackgroundMachine perfusion is a promising strategy for safeguarding liver transplants donated after cardiac death (DCD). In this study, we developed and validated a novel machine perfusion approach for mitigating risk factors and salvaging severe DCD livers.MethodsA novel hypothermic oxygenated perfusion (HOPE) system was developed ...
Lin Fan +5 more
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