Results 81 to 90 of about 2,924,807 (328)

A Vascular Microphysiological Model of Lung Fibrosis Reveals That Myofibroblasts and IPF Patient‐Derived Fibroblasts Impair Angiogenesis and Vasculogenesis

Advanced Functional Materials, EarlyView.
A microphysiological lung fibrosis model recapitulates myofibroblast–vascular interactions. Induced myofibroblasts and patient‐derived IPF fibroblasts impair angiogenesis and increase vascular permeability via TGF‐β1–driven signaling. Pharmacological interventions with SB 431542 and VEGF supplementation restore vascular morphology and barrier function.
Elena Cambria, Adriana Blazeski, Eunkyung Clare Ko, Tran Thai, Shania Dantes, David A. Barbie, Sarah E. Shelton, Roger D. Kamm   +7 more
wiley   +1 more source

A Comparative Study of Single and Dual Perfusion During End-ischemic Subnormothermic Liver Machine Preservation

Transplantation Direct, 2018
Background. It remains controversial if arterial perfusion in addition to portal vein perfusion during machine preservation improves liver graft quality. Comparative studies using both techniques are lacking. We studied the impact of using single or dual
Isabel M.A. Brüggenwirth, BSc, Carolina Moore, PhD, Paria Mahboub, Max F. Thijssen, BSc, Xiaofei E, PhD, Henri G.D. Leuvenink, PhD, Pranoti Mandrekar, PhD, Xiaofei Wang, MD, Timothy F. Kowalik, PhD, Robert J. Porte, MD, PhD, Paulo N. Martins, MD, PhD   +10 more
doaj   +1 more source

Recollections of My Research in Developing the Heart-Lung Machine at Jefferson Medical College [PDF]

, 2005
A personal memoir written by Dr. Bernard J. Miller about his introduction to and interest in medical research as well as his experiences working on the heart-lung machine. He focuses specifically on his working relationship with John H.
Miller, Bernard J.
core   +1 more source

Efficiency of machine perfusion in pediatric liver transplantation

Liver transplantation
Liver transplantation is the only life-saving procedure for children with end-stage liver disease. The field is however heterogenic with various graft types, recipient age, weight, and underlying diseases.
A. Parente, M. Kasahara, V. D. de Meijer, Koji Hashimoto, A. Schlegel   +4 more
semanticscholar   +1 more source

Interconnected Porous Hydrogels with Tunable Anisotropy Through Aqueous Emulsion Bioprinting

Advanced Functional Materials, EarlyView.
A 3D bioprintable microporous bioink is developed using an aqueous two‐phase system (ATPS) composed of extracellular matrix (ECM) mimetic biopolymers. The ATPS bioink enables the fabrication of interconnected porous architectures with up to 70% porosity, supporting long‐term cell viability and 3D cell alignment, enabling a simultaneous generation of ...
Hugo Edgar‐Vilar, Francisca P. Correia, Inês M. Freitas, Vítor M. Gaspar, João F. Mano   +4 more
wiley   +1 more source

Development of a Porcine Slaughterhouse Kidney Perfusion Model

Transplantology, 2021
Machine perfusion techniques are becoming standard care in the clinical donation and transplantation setting. However, more research is needed to understand the mechanisms of the protective effects of machine perfusion.
Leonie H. Venema, Henri G. D. Leuvenink
doaj   +1 more source

Outcome of liver transplantation with grafts from brain‐dead donors treated with dual hypothermic oxygenated machine perfusion, with particular reference to elderly donors

American Journal of Transplantation, 2022
Prompted by the utilization of extended criteria donors, dual hypothermic oxygenated machine perfusion (D‐HOPE) was introduced in liver transplantation to improve preservation.
D. Patrono, D. Cussa, V. Sciannameo, Elena Montanari, R. Panconesi, P. Berchialla, Mirella Lepore, A. Gambella, G. Rizza, Giorgia Catalano, S. Mirabella, F. Tandoi, F. Lupo, R. Balagna, M. Salizzoni, R. Romagnoli   +15 more
semanticscholar   +1 more source

Bioprinting Organs—Science or Fiction?—A Review From Students to Students

Advanced Healthcare Materials, EarlyView.
Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu, Camilla Mussoni, Mateo S. Andrade Mier, Paula Buettner, Nathaly Chicaiza‐Cabezas, Yi‐Yu Robin Dai, Jessica Faber, Maren Fiedler, Zan Lamberger, Xuen Jen Ng, Vanessa Moessler, Anna Rederer, Jonas Roeder, Sabrina Stecher, Katinka Theis, Jeanette Weigelt, Silvia Budday, Gregor Lang, Natascha Schaefer   +18 more
wiley   +1 more source

A Sacrificial 3D Printed Vessel‐on‐Chip Demonstrates a Versatile Approach to Model Granulation Tissue

Advanced Healthcare Materials, EarlyView.
A novel method that combines 3D printing and organ‐on‐chip technology enables the creation of hollow channels lined with endothelial cells through a fibroblast‐populated connective tissue matrix. The model supports stable metabolic culture conditions, angiogenic sprouting, and immune cell migration, thereby demonstrating an easy and versatile method to
Jonas Jäger, Phil Berger, Andrew I. Morrison, Hendrik Erfurth, Maria Thon, Eva‐Maria Dehne, Susan Gibbs, Jasper J. Koning   +7 more
wiley   +1 more source

Use of Machine Perfusion to Increase the Number of Expanded Criteria Deceased Donor Kidney Transplants: A Pharmacoeconomic Analysis

Transplantation Direct
Background. The discard of expanded criteria donor (ECD) kidneys is unacceptably high, considering the growing demand for transplantation. Using machine perfusion may reduce the discard rate, increase the number of transplants, and reduce mortality on ...
Helio Tedesco Silva, Jr, MD, PhD, Teresa Raquel de Moraes Ramos, PhD, Deise De Boni Monteiro de Carvalho, MD, Gustavo Fernandes Ferreira, MD, PhD, João Marcelo Medeiros de Andrade, MD, PhD, Luis Gustavo Modelli de Andrade, MD, PhD, Mario Abbud-Filho, MD, PhD, Renato Demarchi Foresto, MD, MSc, Roberto Ceratti Manfro, MD, PhD, Ronaldo de Matos Esmeraldo, MD, MSc, Tainá Veras de Sandes Freitas, MD, PhD, Valter Duro Garcia, MD, PhD, José Medina Pestana, MD, PhD, Marcelo Cunio Machado Fonseca, MD, PhD   +13 more
doaj   +1 more source