Results 71 to 80 of about 1,725,169 (334)
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
The Journal of Engineering, 2019 A dual three-phase machine with interior permanent magnet rotor and distributed winding has been studied and compared to a commercial automotive traction machine, the Nissan Leaf IPM machine.
Rong Yang +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
ELABORATION OF THE COMPUTATIONAL MODEL OF THE PLANETARY PRECESSIONAL TRANSMISSION
Journal of Industrial Design and Engineering Graphics, 2010 The specific character of sphere-spatial motion used in the precessional transmissions makes impossible the utilization of involute profiles of classical teeth. This fact requires the elaboration of new non-standard profiles, which in conditions of using
BOSTAN Ion +2 more
doaj
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Machine-aided turbulence theory [PDF]
Journal of Fluid Mechanics, 2018 The question of whether significant subvolumes of a turbulent flow can be identified by automatic means, independently of a priori assumptions, is addressed using the example of two-dimensional decaying turbulence. Significance is defined as influence on the future evolution of the flow, and the problem is cast as an unsupervised machine ‘game’ in ...
openaire +3 more sources
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Quantum-Like Interdependence Theory Advances Autonomous Human–Machine Teams (A-HMTs) [PDF]
, 2020 William F. Lawless
openalex +1 more source
Toward a theory of machine learning
Machine Learning: Science and Technology, 2021 Abstract We define a neural network as a septuple consisting of (1) a state vector, (2) an input projection, (3) an output projection, (4) a weight matrix, (5) a bias vector, (6) an activation map and (7) a loss function. We argue that the loss function can be imposed either on the boundary (i.e.
openaire +2 more sources