Results 71 to 80 of about 33,558 (268)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Low-Resourced Alphabet-Level Pivot-Based Neural Machine Translation for Translating Korean Dialects

Applied Sciences
Developing a machine translator from a Korean dialect to a foreign language presents significant challenges due to a lack of a parallel corpus for direct dialect translation.
Junho Park, Seong-Bae Park
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Neural Machine Translation

CoRR, 2017
Draft of textbook chapter on neural machine translation. a comprehensive treatment of the topic, ranging from introduction to neural networks, computation graphs, description of the currently dominant attentional sequence-to-sequence model, recent refinements, alternative architectures and challenges.
openaire   +2 more sources

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Pre-Translation for Neural Machine Translation

CoRR, 2016
Recently, the development of neural machine translation (NMT) has significantly improved the translation quality of automatic machine translation. While most sentences are more accurate and fluent than translations by statistical machine translation (SMT)-based systems, in some cases, the NMT system produces translations that have a completely ...
Jan Niehues, Eunah Cho, Thanh-Le Ha, Alex Waibel   +3 more
openaire   +3 more sources

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Machine Translation in the Hands of Trainee Translators – an Empirical Study

Studies in Logic, Grammar and Rhetoric, 2017
Automated translation (machine translation, MT) is systematically gaining popularity among professional translators, who claim that editing MT output requires less time and effort than translating from scratch.
Sycz-Opoń Joanna, Gałuskina Ksenia
doaj   +1 more source

On Statistical Machine Translation and Translation Theory [PDF]

Proceedings of the Second Workshop on Discourse in Machine Translation, 2015
The translation process in statistical machine translation (SMT) is shaped by technical constraints and engineering considerations. SMT explicitly models translation as search for a target-language equivalent of the input text. This perspective on translation had wide currency in mid-20th century translation studies, but has since been superseded by ...
openaire   +3 more sources