Results 71 to 80 of about 2,700,677 (338)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Design and Analysis of Dual-Rotor Modular-Stator Hybrid-Excited Axial-Flux Permanent Magnet Vernier Machine

Energies, 2022
This paper proposes a new structure of the dual-rotor hybrid-excited axial-flux permanent magnet vernier machine (DR-HEAFPMVM) with the modular stator and the consequent-pole PM (CPM) rotor for low-speed, high torque density applications such as in-wheel
Lun Jia, Mingyao Lin, Keman Lin, Wei Le, Anchen Yang   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

MACHINE-TRANSFORMER UNITS FOR WIND TURBINES

Electrical Engineering & Electromechanics, 2016
Background. Electric generators of wind turbines must meet the following requirements: they must be multi-pole; to have a minimum size and weight; to be non-contact, but controlled; to ensure the maximum possible output voltage when working on the power supply system. Multipole and contactless are relatively simply realized in the synchronous generator
V.I. PANCHENKO, D.V. TSYPLENKOV, A.M. GREBENIUK, M.S. KYRYCHENKO, O.V. BOBROV   +4 more
openaire   +5 more sources

Prediction of the electromagnetic torque in synchronous machines through Maxwell stress harmonic filter (HFT) method [PDF]

, 2006
For the calculation of torque in synchronous motors a local method is analysed, based on the Maxwell stress theory and the filtered contributions due to the harmonics of the magnetic vector potential in the motor air-gap.
Popescu, M.
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Flux observer algorithms for direct torque control of brushless doubly-fed reluctance machines [PDF]

, 2009
Direct Torque Control (DTC) has been extensively researched and applied to most AC machines during the last two decades. Its first application to the Brushless Doubly-Fed Reluctance Machine (BDFRM), a promising cost-effective candidate for drive and ...
Chaal, Hamza, Jovanovic, Milutin
core   +2 more sources

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Performance comparison between Surface Mounted and Interior PM motor drives for Electric Vehicle application [PDF]

, 2012
Electric Vehicles make use of permanent magnet synchronous traction motors for their high torque density and efficiency. A comparison between interior permanent magnet (IPM) and surface mounted permanent magnet (SPM) motors is carried out, in terms of ...
Boazzo, Barbara, Guglielmi, Paolo, Pellegrino, Gian-Mario Luigi, Vagati, Alfredo   +3 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source