Results 121 to 130 of about 4,784,113 (302)

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Tool Wear Monitoring in Milling Based on Fine-Grained Image Classification of Machined Surface Images. [PDF]

Sensors (Basel), 2022
Yang J, Duan J, Li T, Hu C, Liang J, Shi T.   +5 more
europepmc   +1 more source

Machined surface morphologies of Cu samples after the 3rd scratching pass.

, 2015
AFM images of the machined surface of (a) (010), (b) (110) and (c) (111) orientations; (d) presents groove profiles of Cu samples with different orientations.
Yanquan Geng (765985), Tao Sun (91038), Lin Geng (196655), Junjie Zhang (355622), Bowen Yu (765987), Yongda Yan (765986)   +5 more
core   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Fractal Analysis on Machined Surface Morphologies of Soft-Brittle KDP Crystals Processed by Micro Ball-End Milling. [PDF]

Materials (Basel), 2023
Liu Q, Cheng J, Liao Z, Liu M, Chen M, Zhao L, Lei H, Ding W.   +7 more
europepmc   +1 more source

Evolution of surface quality in micromilling Ti-6Al-4V alloy with increasing machined length [PDF]

Micromilling is a subtractive manufacturing process that presents challenges due to scale effects and rapid tool wear. To understand the evolution of surface quality when increasing the machined length during the micromilling process, this study assessed
Alsters, R., Curtis, D., M'Saoubi, R., Gonçalves, Maria Clara Coimbra, Coimbra Goncalves, M.C., Alsters, Rob, M'Saoubi, Rachid, Ghadbeigi, Hassan, Curtis, David, Ghadbeigi, H., Ghadbeigi, Hassan,, Gonçalves, Maria Clara Coimbra,, M'Saoubi, Rachid,, Curtis, David,, Lund University., Alsters, Rob,   +15 more
core   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Fabrication of microfluidic devices: Improvement of surface quality of CO2 laser machined poly(methylmethacrylate) polymer

, 2017
Fabrication of microfluidic devices: Improvement of surface quality of CO2 laser machined poly(methylmethacrylate ...
Abbas Kouzani (13079637), MI Mohammed (14541086), Ian Gibson (13074186), MNH Zainal Alam (14862952)   +3 more
core  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Influence of Lubricant Environment on Machined Surface Quality in Single-Point Diamond Turning of Ferrous Metal. [PDF]

Micromachines (Basel), 2021
Zhou M, Wang J, Zhang G.
europepmc   +1 more source