Results 51 to 60 of about 896,193 (318)

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

open access: yesFEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt   +4 more
wiley   +1 more source

Evolutionary interplay between viruses and R‐loops

open access: yesFEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi   +4 more
wiley   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

Fundamental Investigation of the Application Behavior and Stabilization Potential of Milling Tools with Structured Flank Faces on the Minor Cutting Edges

open access: yesJournal of Manufacturing and Materials Processing
In milling processes in which material removal is performed periodically from solid material, dynamic effects are generally considered to be responsible for instabilities and subsequent productivity limits.
Raphael Isaak Elias Schönecker   +3 more
doaj   +1 more source

Simulation of Residual Stresses in Surface and Subsurface Layer after Machining

open access: yesCommunications, 2016
This article deals with non-destructive detection method of residual stress as analytical tool of expected distribution of residual stress in surface and sub-surface layers.
Andrej Czan   +4 more
doaj   +1 more source

The Mechanism of Layer Stacked Clamping (LSC) for Polishing Ultra-Thin Sapphire Wafer

open access: yesMicromachines, 2020
Double-sides polishing technology has the advantages of high flatness and parallelism, and high polishing efficiency. It is the preferred polishing method for the preparation of ultra-thin sapphire wafer.
Zhixiang Chen   +5 more
doaj   +1 more source

Machining and Machinability of Aluminum Alloys [PDF]

open access: yes, 2011
The use of materials with low specific weight is an effective way of reducing the weight of structures. Aluminum alloys are among the most commonly used lightweight metallic materials as they offer a number of different interesting mechanical and thermal properties.
Imed Zaghbani   +4 more
openaire   +3 more sources

Machine transliteration [PDF]

open access: yesProceedings of the eighth conference on European chapter of the Association for Computational Linguistics -, 1997
It is challenging to translate names and technical terms across languages with different alphabets and sound inventories. These items are commonly transliterated, i.e., replaced with approximate phonetic equivalents. For example, "computer" in English comes out as "konpyuutaa" in Japanese.
Jonathan Graehl, Kevin Knight
openaire   +3 more sources

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Analytic machines

open access: yesTheoretical Computer Science, 1999
AbstractIn this paper we present some results about analytic machines regarding the power of computations over Q or R, solutions of differential equations and the stability problem of dynamical systems.We first explain the machine model, which is a kind of Blum-Shub-Smale machine enhanced by infinite convergent computations.
Hotz, Günter, Chadzelek, Thomas
openaire   +2 more sources

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