Results 61 to 70 of about 34,418 (246)
TechnologiesOne of the limitations of additive manufacturing technology is the high surface roughness of finished products caused by the layered structure of the deposition and the effect of adhesion of unfused powder particles.
Sergey N. Grigoriev +9 more
doaj +1 more source
Cutting Performance of Different Coated Micro End Mills in Machining of Ti-6Al-4V
Micromachines, 2018 Tool wear is a significant issue for the application of micro end mills. This can be significantly improved by coating materials on tool surfaces. This paper investigates the effects of different coating materials on tool wear in the micro milling of Ti ...
Zhiqiang Liang +5 more
doaj +1 more source
Conduction-Based Thermally Assisted Micromilling Process for Cutting Difficult-to-Machine Materials
Journal of Manufacturing and Materials Processing, 2020 The increasing demand for complex and wear-resistant forming tools made of difficult-to-machine materials requires efficient manufacturing processes. In terms of high-strength materials; highly suitable processes such as micromilling are limited in their
Timo Platt +2 more
doaj +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Machine Learned Learning Machines
, 2017 There are two common approaches for optimizing the performance of a machine: genetic algorithms and machine learning. A genetic algorithm is applied over many generations whereas machine learning works by applying feedback until the system meets a performance threshold. Though these are methods that typically operate separately, we combine evolutionary
Sheneman, Leigh, Hintze, Arend
openaire +2 more sources
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Experimental study on lapping ceramic balls with variable-radius groove plate
Advances in Mechanical Engineering, 2021 The method of lapping precision ball with variable-radius groove is developed in recent years. An experimental study on lapping ceramic balls with variable-radius groove was carried out.
Fenfen Zhou +5 more
doaj +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Significant Influence on Residual Bending Strength by Cracks Generation During Grinding of Ceramics
Chinese Journal of Mechanical EngineeringAny product must undergo precise manufacturing before use. The damage incurred during the manufacturing process can significantly impact the residual strength of the product post-manufacturing.
Jinshuo Zhang +5 more
doaj +1 more source
Energies, 2020 Energy baseline is an important method for measuring the energy-saving benefits of chiller system, and the benefits can be calculated by comparing prediction models and actual results.
Chun-Wei Chen +2 more
doaj +1 more source