Results 41 to 50 of about 22,928 (311)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Research on Multi-Physical Field Coupling Simulation of Local Electrochemical Machining
Applied Sciences, 2023 Casing is one of the most important components of an aircraft engine. However, due to its thin wall thickness and difficult-to-cut materials, it is difficult to process with a conventional mechanical method.
Jian Yu, Dengyong Wang
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Micromachines, 2020 Optical aspheric components are inevitably affected by various disturbances during their precision machining, which reduces the actual machining accuracy and affects the optical performance of components.
Yingchun Li +4 more
doaj +1 more source
The Distribution Pattern of Machining Errors on Woodworking Machine Tools
Журнал інженерних наук, 2023 The article aims to develop a methodology for calculating and predicting the distribution patterns of wood machining errors to assess the operating conditions of the machine tool according to the technological accuracy criterion.
Pylypchuk M. I. +4 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Fabrication of a side aligned optical fibre inteferometer by focused ion beam machining
, 2013 Focused ion beam (FIB) machining is a promising technique for the fabrication of micro-optical components with high quality surface finishes. In this work, a prototype of a side aligned optical fibre interferometer was successfully fabricated by the ...
Ritchie, J. M. +13 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Design and analysis of the internally cooled smart cutting tools with the applications to adaptive machining [PDF]
, 2013 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Adaptive machining with internally cooled smart cutting tools is a smart solution for industrial applications, which have stringent manufacturing ...
Bin Che Ghani, Saiful Anwar
core
Limiting current density in electrochemical micromachining
Journal of Electrochemical Science and Engineering, 2018 In this paper, a method of calculating the diffusion current density on the electric pole in the electrochemical micromachining is proposed. Changes of the diffusion current with system factors are investigated from which a method of increasing the ...
Chuanjun Zhao, Lizhong Xu
doaj +1 more source