Results 41 to 50 of about 2,330,665 (285)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The Distribution Pattern of Machining Errors on Woodworking Machine Tools

open access: yesЖурнал інженерних наук, 2023
The article aims to develop a methodology for calculating and predicting the distribution patterns of wood machining errors to assess the operating conditions of the machine tool according to the technological accuracy criterion.
Pylypchuk M. I.   +4 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

A Study on the Foundation Design of Large Machining Center for Highly Precision [PDF]

open access: yes한국정밀공학회지, 2018
With the advent of high-tech products, the need for ultra-precision machining has become increasingly necessary, along with the need for a jig center machining center capable of precision machining. A jig center maintains the accuracy of a jig borer, and
Seonghwa Cho, Changwoo Lee
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Simulation Analysis of Multi-Physical Field Coupling and Parameter Optimization of ECM Miniature Bearing Outer Ring Based on the Gas-Liquid Two-Phase Turbulent Flow Model

open access: yesMicromachines, 2022
Electrochemical machining (ECM) is an essential method for machining miniature bearing outer rings on the high-temperature-resistant nickel-based alloy GH4169. However, the influence of electrolyte temperature distribution and bubble rate distribution on
Zhaolong Li, Wangwang Li, Bingren Cao
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Cost of photochemical machining [PDF]

open access: yes, 2004
Photochemical machining (PCM), also known as photoetching, photofabrication or photochemical milling, is a non-traditional manufacturing method based on the combination of photoresist imaging and chemical etching.
Roy, Rajkumar   +2 more
core   +1 more source

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