Results 51 to 60 of about 6,382,755 (302)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

The Accuracy of Forming Rectangular Tenons by End-Pressing without Guiding Tooling

Лесной журнал
The article presents an analysis of experimental data on the manufacturing accuracy of tenon joint elements in pine workpieces produced by end pressing without using locating-clamping tooling.
Yaroslav D. Vedernikov, Olga A. Rubleva, Elizaveta S. Vasilyeva, Elena E. Shishkina, Alexandr G. Gorokhovsky   +4 more
doaj   +1 more source

A study of electrodischarge machining–pulse electrochemical machining combined machining for holes with high surface quality on superalloy

Advances in Mechanical Engineering, 2015
Noncircular holes on the surface of turbine rotor blades are usually machined by electrodischarge machining. A recast layer containing numerous micropores and microcracks is easily generated during the electrodischarge machining process due to the rapid ...
Ning Ma, Xiaolong Yang, Mingqian Gao, Jinlong Song, Ganlin Liu, Wenji Xu   +5 more
doaj   +1 more source

Material removal rate and machining accuracy of electrical discharge machining (EDM) of Inconel 718 using copper electrode

IOP Conference Series: Materials Science and Engineering, 2019
Electrical Discharge Machining (EDM) is a non-contact thermal machining process capable of machining conductive and semi-conductive materials. These capabilities bring to admission of machining materials that characteristically difficult to machine such ...
S. Ahmad, R. N. Chendang, A. Supawi, M. A. Lajis, M. Zaman   +4 more
semanticscholar   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Research on adaptive belt grinding aeroengine titanium alloy fan blades

Jin'gangshi yu moliao moju gongcheng, 2018
Most aeroengine blades are made of titanium alloys, which have good strength and mechanical properties, but poor machinability. The surface precision and surface quality of the blades after precision forging and precision milling need to be machined to ...
ZHANG Hongzhi, LIANG Qiaoyun, CHEN Shengtian, WANG Jie, HUANG Yun, ZOU Lai   +5 more
doaj  

Limiting current density in electrochemical micromachining

Journal of Electrochemical Science and Engineering, 2018
In this paper, a method of calculating the diffusion current density on the electric pole in the electrochemical micromachining is proposed. Changes of the diffusion current with system factors are investigated from which a method of increasing the ...
Chuanjun Zhao, Lizhong Xu
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

High precision and consistent machining of cylindrical rollers using ceramic lapping plates with both-sides machining method

Journal of Materials Research and Technology
To address the issue of rapid wear and loss of shape accuracy in traditional both-sides lapping plates, which limits the further application of both-sides machining for high-precision cylindrical rollers, an extremely high precision and consistent ...
Tianchen Zhao, Kaiping Feng, Luguang Guo, Binghai Lyu, Weifeng Yao, Junkai Ding, Julong Yuan   +6 more
doaj   +1 more source