Results 51 to 60 of about 22,928 (311)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Simulation Analysis of Multi-Physical Field Coupling and Parameter Optimization of ECM Miniature Bearing Outer Ring Based on the Gas-Liquid Two-Phase Turbulent Flow Model

Micromachines, 2022
Electrochemical machining (ECM) is an essential method for machining miniature bearing outer rings on the high-temperature-resistant nickel-based alloy GH4169. However, the influence of electrolyte temperature distribution and bubble rate distribution on
Zhaolong Li, Wangwang Li, Bingren Cao
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

A study of electrodischarge machining–pulse electrochemical machining combined machining for holes with high surface quality on superalloy

Advances in Mechanical Engineering, 2015
Noncircular holes on the surface of turbine rotor blades are usually machined by electrodischarge machining. A recast layer containing numerous micropores and microcracks is easily generated during the electrodischarge machining process due to the rapid ...
Ning Ma, Xiaolong Yang, Mingqian Gao, Jinlong Song, Ganlin Liu, Wenji Xu   +5 more
doaj   +1 more source

Analysis of electrochemical machining process with ultrashort pulses considering stray inductance of pulse power supply

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2018
Machining characteristics of electrochemical machining with ultrashort pulses were investigated using numerical analysis considering the inductance of a power supply circuit. In a pulse power supply circuit of ECM, stray inductance occurs in the electric
Tomohiro KOYANO, Akira HOSOKAWA, Tatsuaki FURUMOTO   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The Accuracy of Forming Rectangular Tenons by End-Pressing without Guiding Tooling

Лесной журнал
The article presents an analysis of experimental data on the manufacturing accuracy of tenon joint elements in pine workpieces produced by end pressing without using locating-clamping tooling.
Yaroslav D. Vedernikov, Olga A. Rubleva, Elizaveta S. Vasilyeva, Elena E. Shishkina, Alexandr G. Gorokhovsky   +4 more
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Intelligent integrated framework towards high-accuracy machining

, 2023
The thermal error is the main factor hindering the realization of the high-accuracy machining. The intelligent integrated framework towards the high-accuracy machining, which is expected to realize improve the machining accuracy, is scarcely reported so ...
Lang Zhang, Hongquan Gui, Jialan Liu, Chi Ma   +3 more
core   +1 more source

High precision and consistent machining of cylindrical rollers using ceramic lapping plates with both-sides machining method

Journal of Materials Research and Technology
To address the issue of rapid wear and loss of shape accuracy in traditional both-sides lapping plates, which limits the further application of both-sides machining for high-precision cylindrical rollers, an extremely high precision and consistent ...
Tianchen Zhao, Kaiping Feng, Luguang Guo, Binghai Lyu, Weifeng Yao, Junkai Ding, Julong Yuan   +6 more
doaj   +1 more source