Results 141 to 150 of about 6,927 (264)

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

The Promethean Gap: Modernism, Machines, and the Obsolescence of Man

Modernism/modernity, 2016
openaire   +2 more sources

Data-driven machine learning modelling in wire EDM of TiNiCo shape memory alloy. [PDF]

Sci Rep
Tyagi R, Soni H, Tripathi A, Rahman SMN, Mbohwa C, Prasad CD, Tiwari SK.   +6 more
europepmc   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Thermal conductivity and viscosity characterization of soybean oil nanofluids dispersed with graphene nanoplatelets, MoS₂, TiO₂ and Al₂O₃ nanoparticles for MQL machining. [PDF]

Discov Nano
Okafor AC, Valiev SE, Abor TK, Ekengwu IE, Saka A, Okoronkwo MU.   +5 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Evaluation of cutting speed and surface roughness in WEDM of functionally graded A356-10 wt% Si₃N₄ composite. [PDF]

Sci Rep
Prathap Singh S, Elil Raja D, Ramesh Kumar C, Gnanasekaran K, Bhowmik A, Hussen K, Sowndar S, Sundara Cholan M.   +7 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Two-Step Polishing Technique for Flat and Smooth Copper Substrates by Electrochemical and Chemical Etching. [PDF]

Micromachines (Basel)
Wang K, Chen X, Hou B, Xu P, Li Y, Liu X, Shi H, Zhang M, Wang H.   +8 more
europepmc   +1 more source