Results 111 to 120 of about 13,866,091 (364)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Machining of aluminium based Metal Matrix Composite (MMC) [PDF]

The machining of aluminium 2618 particulate reinforced Metal Matrix Composite (MMC) with 18 vol. % silicon carbide (SiC) using cemented carbide cutting tools has been undertaken.
Abdullah, Abu
core  

Structural analysis and chracterisation technique applied to a CNC vertical machining centre

, 2014
There is a requirement for improved 3D surface characterisation and reduced tool wear, when modern computer numerical-controlled (CNC) machine tools are operating at high cutting velocities, spindle speeds and feed-rates.
Widiyarto, Muhammad Helmi Nur, Longstaff, Andrew P., Fletcher, Simon, Ford, Derek G., Myers, Alan   +4 more
core   +1 more source

Experimental investigation on micromilling of oxygen-free, high-conductivity copper using tungsten carbide, chemistry vapour deposition and single-crystal diamond micro tools [PDF]

, 2010
Insufficient experimental data from various micro tools limit industrial application of the micromilling process. This paper presents an experimental comparative investigation into micromilling of oxygen-free, high-conductivity copper using tungsten ...
Cheng, K, D Huo, K Cheng, Huo, D
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Performance evaluation of machining strategy for engine-block manufacturing

, 2015
This paper will introduce a novel methodology for the performance evaluation of machining strategies of engine block manufacturing. The manufacturing of engine components is vital to the automotive and vehicle manufacturing industries.
Nicolescu, Mihai, Adane, Tigist Fetene, Bianchi, Maria Floriana, Archenti, Andreas   +3 more
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A holistic integrated dynamic design and modelling approach applied to the development of ultraprecision micro-milling machines

, 2009
Ultraprecision machines with small footprints or micro-machines are highly desirable for micro-manufacturing high-precision micro-mechanical components.
Wardle, F, Cheng, K, Huo, D
core   +1 more source

Pulsed laser machining of high-performance engineering and biomedical alloys

, 2020
The exceptional mechanical and thermal properties of high-performance engineering and biomedical alloys lead to difficulties in machining with conventional processes.
Romoli L., Cucinotta A., Perveen A., Lutey A. H. A., Selleri S.   +4 more
core   +1 more source

Experimental and simulation investigation of ultrasonic elliptical vibration cutting of tungsten alloys in ultra-precision machining

Journal of Materials Research and Technology
Ultrasonic elliptical vibration cutting (UEVC) offers the benefits of extending tool life and enhancing surface finish, enabling ultra-precision machining of hard-brittle tungsten alloys.
Sen Yin, Wai Sze Yip, Zhigang Dong, Renke Kang, Suet To   +4 more
doaj   +1 more source