Results 101 to 110 of about 13,866,091 (364)

Influence of rake face texturing on machining performance of carbide tools

Procedia CIRP, 2019
Controlled surface texture of cutting tools has potential to reduce cutting forces, tool wear, etc. Even though several different textured cutting tools have been identified and tested in machining of various workpiece materials, it is difficult to ...
D. Grguraš, F. Pušavec
semanticscholar   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Analytical and experimental study of feed rate in high-speed milling [PDF]

, 2013
In the context of high-speed milling (HSM), during the machining process dynamic machine response has to be identified. To achieve this, we have to calculate the feed rate evolution in linear and circular interpolation according to dynamic performance of
Baili, Maher, Hbaieb, Moncef, Dessein, Gilles, Saï, Wassila Bouzid, Gassara, Bassem   +4 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Machining of ceramic components - process-technological potentials

, 2022
In the production of ceramic components machining in the green state bears many advantages according to flexibility and economy. This holds true especially for small lot sizes when compared to forming processes like moulding and pressing.
König, Wilfried, Wagemann, A.
core  

Experimental investigation on electrochemical discharge machining of hastelloy

Materials Research Express
The study examines the influence of various process parameters on Material Removal Rate (MRR), Tool Wear Rate (TWR) AND Surface Roughness (R _a ) during the machining of Hastelloy using Electrical Discharge Machining (EDM) machined under NaOH dielectric ...
Kanulla Karthik, Ranjith R, Venkatrami Reddy Veduru, Kawin Nallasivam   +3 more
doaj   +1 more source

Optimizing Dual-Microstructure Parameters in Ball-End Milling Tools: Synergistic Effects and Parameter Combination Analysis

Applied Sciences
To address the issues of high cutting speeds and low surface precision during milling, this study investigates the effects of front and back cutting face microstructures on ball-end milling cutters processing 304 stainless steel.
Qinghua Li, Qingyu Guan, Yi Ji, Wenyang Xu, Tiantian Xu   +4 more
doaj   +1 more source

Alternative Trajectories for the Optimization of Trochoidal Milling in Hardened Steel [PDF]

Materials Research
This study investigates the machining performance of trochoidal toolpaths in hardened AISI 4340 steel. Three toolpaths—conventional, horizontal semi-ellipse, and vertical semi-ellipse—were analyzed in terms of machining time and machining forces under ...
Kaciê K.A. Trindade, Josean da S. Lima Junior, Maxime Montoya, Alessandro R. Rodrigues, Kleber G.B. Alves, Flávio J. da Silva   +5 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source