Results 81 to 90 of about 13,866,091 (364)

Influence of Cutting Parameters and MQL on Surface Finish and Work Hardening of Inconel 617

Applied Sciences
Inconel 617 is a nickel-based superalloy that is a primary candidate for use in next-generation nuclear applications such as the Gen IV Molten Salt Reactor (MSR) and Very-High-Temperature Reactor (VHTR) due to its corrosion and oxidation resistance and ...
Rachel Lai, Andres Hurtado Carreon, Jose M. DePaiva, Stephen C. Veldhuis   +3 more
doaj   +1 more source

CONDITIONS OF REDUCED COST FOR MACHINE-BUILDING PRODUCTS [PDF]

Fiabilitate şi Durabilitate, 2019
The mathematical model for the cost of processing of machine parts was developed and the conditions for its reduction were determined. Analytically established the existence of a minimum of the cost of processing which achieved at high cutting speeds ...
Dmytro NOVIKOV, Yury GUTSALENKO, Feodor NOVIKOV   +2 more
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microstructure, Mechanical, and Machining Properties of 2024 Al Composites Reinforced with TiB₂, SiC, and Diamond Particles

Metals
Particle-reinforced aluminum matrix composites demonstrate remarkable potential for use in aerospace, precision instruments, and electronic packaging applications due to their superior specific strength, high specific stiffness, and low thermal expansion
Chuan Tan, Shuang Xiong, Qianwen Bi, Hui Wang, Bin Li, Limin Jiang, Jianhong Yi, Xiaoqing Zuo   +7 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Enhancing the machining performance by cutting tool surface modifications: a focused review

Machining science and technology, 2019
In machining, cutting tools suffer from severe surface wear, especially in the cutting of difficult-to-cut materials. A major cause of tool wear is the friction generated at the tool-work and tool-chip interfaces, which produces a great deal of ...
Yuhan Chen, Jun Wang, Ming Chen
semanticscholar   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Mechanical and Tribological Properties of (AlCrNbSiTiMo)N High-Entropy Alloy Films Prepared Using Single Multiple-Element Powder Hot-Pressed Sintered Target and Their Practical Application in Nickel-Based Alloy Milling

Lubricants
(AlCrNbSiTiMo)N high-entropy alloy films with different nitrogen contents were deposited on tungsten carbide substrates using a radio-frequency magnetron sputtering system.
Jeng-Haur Horng, Wen-Hsien Kao, Wei-Chen Lin, Ren-Hao Chang   +3 more
doaj   +1 more source

Abrasive water jet machining of fiber reinforced polymer composite materials: A review [PDF]

Journal of Engineering Science and Military Technologies
Fiber reinforced polymer composites (FRPC) have become integral to materialsystems due to their exceptional performance in specific applications. The existence of fiber inclusion and the heterogeneous composition of composites present challenges for ...
Mohamed Abohaggie, Ahmed Mesalamy, Yasser Elsherbini, Ahmed Elsabbagh   +3 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source