Results 201 to 210 of about 13,257 (251)
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Macrocycle Breathing in [2]Rotaxanes with Tetralactam Macrocycles
The Journal of Organic Chemistry, 2010The structural dynamics of two pairs of [2]rotaxanes were compared using variable-temperature NMR. Each rotaxane had a surrounding tetralactam macrocycle with either 2,6-pyridine dicarboxamide or isophthalamide bridging units. Differences were observed in two types of rotational processes: spinning of the phenylene wall units in the surrounding ...
Ivan, Murgu +5 more
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Direct conversion of macrocyclic furans into macrocyclic isothiazoles
Chemical Communications, 2002The first calixhetarenes with more than one heteroatom in the constituent rings are prepared in one step by treatment of calix[4]furan 1a and calix[6]furan 1b with ethyl carbamate, thionyl chloride and pyridine to give 2, 3, 4 and 5, 6, 7 respectively; these products have been characterised by X-ray crystallography which reveals that in 2 all eight ...
Jérôme, Guillard +4 more
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Tuning the size of macrocyclic cavities in trianglimine macrocycles
Organic & Biomolecular Chemistry, 2005The synthesis of aromatic dicarboxaldehydes is described along with their reactivity in the [3 + 3] cyclocondensation reaction with (1R,2R)-diaminocyclohexane to give trianglimine macrocycles. In particular, the scope and limitation of the reaction with regard to complete control of the cavity size of the macrocycles is discussed producing a total of ...
Nikolai, Kuhnert +3 more
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Reversible Macrocycle-to-Macrocycle Interconversion Driven by Solvent Selection
Journal of the American Chemical Society, 2023Macrocycle-to-macrocycle interconversions are of interest because they can allow access to a variety of structures. However, reversible interconversion between different sized macrocycles remains challenging to control. Herein, we report a facile one-pot synthesis of a series of self-assembled macrocycles from readily prepared α,α'-linked oligopyrrolic
Fei Wang +7 more
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The macrocyclic effect in tetraaza-macrocyclic ligands
Inorganica Chimica Acta, 1980Abstract The origin of the Macrocyclic Effect [1] in complexes of cyclam as compared with those of its open-chain analogue 2,3,2- tet is discussed. It is not readily apparent that the presence of four secondary (2°) nitrogens in cyclam , as opposed to two primary (1°) and two 2° in 2,3,2- tet should make much difference, since the pK a 's of 2 ...
R.D. Hancock, G.J. McDougall
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Macrocyclic Proteasome Inhibitors
Current Medicinal Chemistry, 2011Proteasome inhibitors have proven to be effective anticancer agents. Despite the success of the first on the market proteasome inhibitor bortezomib in chemotherapy, alternative clinically useful proteasome inhibitors are still urgently needed as bortezomib therapy causes severe side effects and is limited by arising drug resistance.
Krahn, D., Ottmann, C., Kaiser, Markus
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Application of Ruthenium-Induced Macrocyclization for the Construction of Macrocyclic Depsipeptides
The Journal of Organic Chemistry, 2002The synthesis of a biaryl ether containing macrocyclic depsipeptide 1 was achieved in 6% overall yield. The desired macrocycle was constructed by cyclization of a phenol into eta(6)-ruthenium complex. The ruthenium metal was subsequently photolytically deprotected to obtain the macrocycle 1.
Srikanth, Venkatraman +3 more
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Modulation by macrocyclic peptides
Science Signaling, 2022Cell-permeable, macrocyclic peptides antagonize either the active or the inactive states of Gα s to fine-tune signaling.
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Reply to: Macrocyclic colibactins
Nature Chemistry, 2020Herzon, S. B. Macrocyclic colibactins. Nat. Chem. https://doi.org/10.1038/s41557-020-00551-8 (2020). Li, Z.-R. et al. Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage. Nat. Chem. 11, 880–889 (2019).
Wenjun Zhang, Pei-Yuan Qian
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Metamorphosis of Tetrapyrrole Macrocycles
ChemInform, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Mathias O, Senge, Natalia N, Sergeeva
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