Results 1 to 10 of about 21,344 (285)
Synlett, 2018 Artificial macrocycles recently became popular as a novel research field in drug discovery. As opposed to their natural twins, artificial macrocycles promise to have better control on synthesizability and control over their physicochemical properties resulting in druglike properties. Very few synthetic methods allow for the convergent, fast but diverse
Abdelraheem +3 more
openaire +6 more sources
Macrocyclic Drugs and Synthetic Methodologies toward Macrocycles [PDF]
Molecules, 2013 Macrocyclic scaffolds are commonly found in bioactive natural products and pharmaceutical molecules. So far, a large number of macrocyclic natural products have been isolated and synthesized. The construction of macrocycles is generally considered as a crucial and challenging step in the synthesis of macrocyclic natural products.
Xufen Yu, Dianqing Sun
openaire +4 more sources
Frontiers in Chemistry, 2022 The special geometric configurations and optoelectronic properties of p-conjugated macrocycles have always been the focus of materials science. The incorporation of building moieties with different features into macrocycles can not only change their ...
Dongyue An +5 more
doaj +1 more source
Imine- and Amine-Type Macrocycles Derived from Chiral Diamines and Aromatic Dialdehydes
Molecules, 2022 The condensation of aromatic dialdehydes with chiral diamines, such as 1,2-trans-diaminocyclohexane, leads to various enantiopure or meso-type macrocyclic Schiff bases, including [2 + 2], [3 + 3], [4 + 4], [6 + 6] and [8 + 8] condensation products ...
Jerzy Lisowski
doaj +1 more source
Molecules, 2021 Glycomacrolactones exhibit many interesting biological properties, and they are also important in molecular recognitions and for supramolecular chemistry.
Surya B. Adhikari +2 more
doaj +1 more source
Scientific Reports, 2022 The design and synthesis of a versatile class of macrocycles with tunable functional groups and ring size are unfolded. Herein, a synthetic strategy is reported to furnish a new class of macrocycles in multi-gram scale in a two-step reaction.
Liya Thurakkal +2 more
doaj +1 more source
Near quantitative synthesis of urea macrocycles enabled by bulky N-substituent
Nature Communications, 2021 Macrocycles are molecular structures extensively used in the design of catalysts, therapeutics and supramolecular assemblies but synthesis procedures that can produce macrocycles in high yield under high reaction concentrations are rare. Here the authors
Yingfeng Yang +10 more
doaj +1 more source
Nanomaterials, 2023 Macrocycles have attracted significant attention from academia due to their various applications in organic field-effect transistors, organic light-emitting diodes, organic photovoltaics, and dye-sensitized solar cells.
Chunxiao Zhong +9 more
doaj +1 more source
Size-control in the synthesis of oxo-bridged phosphazane macrocycles via a modular addition approach
Communications Chemistry, 2021 Cyclodiphosphazane macrocycles have demonstrated promising host-guest chemistry, but synthetic routes to highorder versions are lacking. Here the authors synthesise high-order oxygen-bridged phosphazane macrocycles via a modular cyclisation strategy.
Xiaoyan Shi +5 more
doaj +1 more source