Results 1 to 10 of about 5,793 (229)
A Stepwise Approach to 1,4,10,13‐Tetraaza‐18‐Crown‐6 Ether [PDF]
ChemistryOpenA two‐step approach to the synthesis of tetraaza‐18‐crown‐6 ether was evaluated to address the limitations of the currently used one‐step macrocyclization, such as low yield due to substantial side product formation.
Pieter Troosters +3 more
doaj +2 more sources
Indole-Based Macrocyclization by Metal-Catalyzed Approaches [PDF]
Organics, 2023 This review is dedicated to the different varieties of macrocycles synthesis bearing indole units in their architecture by metal-catalyzed strategies.
Subba Rao Cheekatla +4 more
doaj +2 more sources
Macrocyclic Drugs and Synthetic Methodologies toward Macrocycles [PDF]
Molecules, 2013 Macrocyclic scaffolds are commonly found in bioactive natural products and pharmaceutical molecules. So far, a large number of macrocyclic natural products have been isolated and synthesized.
Xufen Yu, Dianqing Sun
doaj +3 more sources
Electro-induced C-H/S-H cross-coupling for the functionalization/macrocyclization of cysteine-containing peptides [PDF]
Nature CommunicationsHerein, an electro-induced umpolung approach that enables the efficient functionalization/macrocyclization of cysteine-containing peptides is reported. Notably, this method utilizes simple halogen source and takes metal-mediated halogen atom transfer as ...
Fang Xiang +6 more
doaj +2 more sources
Molbank, 2023 Copper(I)-catalyzed azide-alkyne cycloaddition was employed to construct biscalixarene assemblies from the calix[4]arene dipropargyl ethers and 4,4′-bis-azidomethylated azobenzene or stilbene.
Ivan Lentin +6 more
doaj +1 more source
Synthesis and Biological Activities of Cyclodepsipeptides of Aurilide Family from Marine Origin
Marine Drugs, 2021 Aurilides are a class of depsipeptides occurring mainly in marine cyanobacteria. Members of the aurilide family have shown to exhibit strong cytotoxicity against various cancer cell lines.
Synthia Michon +2 more
doaj +1 more source
Molecules, 2022 Macrocycles represent attractive candidates in organic synthesis and drug discovery. Since 2014, nineteen macrocyclic drugs, including three radiopharmaceuticals, have been approved by FDA for the treatment of bacterial and viral infections, cancer ...
Dianqing Sun
doaj +1 more source
Synlett, 2018 Artificial macrocycles recently became popular as a novel research field in drug discovery. As opposed to their natural twins, artificial macrocycles promise to have better control on synthesizability and control over their physicochemical properties resulting in druglike properties. Very few synthetic methods allow for the convergent, fast but diverse
Abdelraheem +3 more
openaire +2 more sources
Structural basis of ribosomal peptide macrocyclization in plants
eLife, 2018 Constrained, cyclic peptides encoded by plant genes represent a new generation of drug leads. Evolution has repeatedly recruited the Cys-protease asparaginyl endopeptidase (AEP) to perform their head-to-tail ligation. These macrocyclization reactions use
Joel Haywood +7 more
doaj +1 more source
Applied Sciences, 2022 The study’s aim was to synthesize new unsymmetrical sulfanyl zinc(II) porphyrazines and subject them to physicochemical and electrochemical characterization and also an initial acute toxicity assessment.
Patrycja Koza +3 more
doaj +1 more source