Results 1 to 10 of about 3,332 (181)
A Stepwise Approach to 1,4,10,13‐Tetraaza‐18‐Crown‐6 Ether [PDF]
ChemistryOpenA two‐step approach to the synthesis of tetraaza‐18‐crown‐6 ether was evaluated to address the limitations of the currently used one‐step macrocyclization, such as low yield due to substantial side product formation.
Pieter Troosters +3 more
doaj +2 more sources
Macrocyclic Drugs and Synthetic Methodologies toward Macrocycles [PDF]
Molecules, 2013 Macrocyclic scaffolds are commonly found in bioactive natural products and pharmaceutical molecules. So far, a large number of macrocyclic natural products have been isolated and synthesized.
Xufen Yu, Dianqing Sun
doaj +3 more sources
Electro-induced C-H/S-H cross-coupling for the functionalization/macrocyclization of cysteine-containing peptides [PDF]
Nature CommunicationsHerein, an electro-induced umpolung approach that enables the efficient functionalization/macrocyclization of cysteine-containing peptides is reported. Notably, this method utilizes simple halogen source and takes metal-mediated halogen atom transfer as ...
Fang Xiang +6 more
doaj +2 more sources
Synlett, 2018 Artificial macrocycles recently became popular as a novel research field in drug discovery. As opposed to their natural twins, artificial macrocycles promise to have better control on synthesizability and control over their physicochemical properties resulting in druglike properties. Very few synthetic methods allow for the convergent, fast but diverse
Abdelraheem +3 more
openaire +2 more sources
Molbank, 2023 Copper(I)-catalyzed azide-alkyne cycloaddition was employed to construct biscalixarene assemblies from the calix[4]arene dipropargyl ethers and 4,4′-bis-azidomethylated azobenzene or stilbene.
Ivan Lentin +6 more
doaj +1 more source
Symmetric Macrocycles by a Prins Dimerization and Macrocyclization Strategy [PDF]
Organic Letters, 2009 A tandem dimerization/macrocyclization reaction utilizing the Prins cyclization has been developed. This reaction develops molecular complexity through the formation of highly substituted dimeric tetrahydropyran macrocycles. Mild conditions utilizing rhenium(VII) catalysts were explored for aromatic substrates, while harsher Lewis acidic conditions ...
Michael R, Gesinski +2 more
openaire +2 more sources
Synthesis and Biological Activities of Cyclodepsipeptides of Aurilide Family from Marine Origin
Marine Drugs, 2021 Aurilides are a class of depsipeptides occurring mainly in marine cyanobacteria. Members of the aurilide family have shown to exhibit strong cytotoxicity against various cancer cell lines.
Synthia Michon +2 more
doaj +1 more source
Indole-Based Macrocyclization by Metal-Catalyzed Approaches
Organics, 2023 This review is dedicated to the different varieties of macrocycles synthesis bearing indole units in their architecture by metal-catalyzed strategies.
Subba Rao Cheekatla +4 more
doaj +1 more source
Molecules, 2022 Macrocycles represent attractive candidates in organic synthesis and drug discovery. Since 2014, nineteen macrocyclic drugs, including three radiopharmaceuticals, have been approved by FDA for the treatment of bacterial and viral infections, cancer ...
Dianqing Sun
doaj +1 more source
Pharmaceuticals, 2023 Kinases play an important role in regulating various intracellular signaling pathways that control cell proliferation, differentiation, survival, and other cellular processes, and their deregulation causes more than 400 diseases.
Swapnil P. Bhujbal, Jung-Mi Hah
doaj +1 more source