Results 41 to 50 of about 6,559 (227)

First Total Synthesis and Biological Screening of a Proline-Rich Cyclopeptide from a Caribbean Marine Sponge

Marine Drugs, 2016
A natural heptacyclopeptide, stylissamide G (7), previously isolated from the Bahamian marine sponge Stylissa caribica from the Caribbean Sea, was synthesized via coupling of the tetrapeptide l-phenylalanyl-l-prolyl-l-phenylalanyl-l-proline methyl ester ...
Rajiv Dahiya, Sunil Singh, Ajay Sharma, Suresh V. Chennupati, Sandeep Maharaj   +4 more
doaj   +1 more source

One‐Step Access to Ultra‐Bright Macrocyclic Oligo‐BODIPYs Featuring Long‐Lived Cyclic Excitons

Angewandte Chemie, EarlyView.
Strong Fluorescence Meets Long Lifetimes: A template‐free, one‐step synthesis affords a series of methylene‐bridged macrocyclic oligo‐BODIPYs combining strong fluorescence with exceptionally long fluorescence lifetimes. Steady‐state and time‐resolved optical spectroscopy reveal unique excitonic coupling conditions and unusual size‐dependent ...
Lukas J. Patalag, Atanu Patra, Mike Pauls, Roland Wilcken, Yuriy Kononevich, Nils van Staalduinen, Peter G. Jones, Andreas Steffen, Thorben Cordes, Christoph Bannwarth, Daniel B. Werz   +10 more
wiley   +2 more sources

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Peptide Macrocyclization via Cu-catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides [PDF]

Cyclic peptides are highly valued synthetic targets in organic and medicinal chemistry. The development of new synthetic methodologies for peptide macrocyclization, different from classical lactamization, is essential for the progress of the field ...
Francisco Javier, Adrio, Juan Carlos, Carretero, Inés, Alonso, Enrique, Gallent, Nuria, Rodriguez   +4 more
core   +1 more source

Catalytic macrocyclization of unactivated C(sp3)-H bond in natural product synthesis

Tetrahedron Green Chem
Macrocyclic natural products present as essential scaffolds in drug development. Excited by the biological properties of macrocyclic natural products, its synthesis and the development of macrocyclization methods is an important research area in organic ...
Zhuo Wang
doaj   +1 more source

Macrocyclization of ω‐Isocyano Aldehydes

Angewandte Chemie, EarlyView.
The ω‐isocyano aldehydes readily undergo cyclization to afford α‐acyloxy, α‐hydroxy, α‐acetamido, and α‐keto macrolactams, as well as tetrazole‐fused macrocycles, via C(sp3)─C(sp2) bond formation, providing access to diverse α‐functionalized medium‐sized lactams and macrolactams. ABSTRACT Medium‐sized rings and macrocycles constitute a privileged class
Baochao Yang, Teerawat Songsichan, Cyril Piemontesi, Qian Wang, Jieping Zhu   +4 more
wiley   +2 more sources

Polycavernoside A: The Prins Macrocyclization Approach

, 2016
Polycavernoside A: The Prins Macrocyclization ...
Eun Lee (418436), Sang Kook Woo (1979239)   +1 more
core   +1 more source

Characterization of a Fungal Modular Polyketide Synthase System Reveals an Unusual Strategy for Polyketide Chain Initiation

Angewandte Chemie, EarlyView.
Fungal modular polyketide synthases (PKSs) remain largely unexplored. Functional characterization of the LasC/LasD assembly line established its role in strasseriolide C biosynthesis and suggested an unexpected strategy for chain initiation, in which a malonyl unit is transferred from the module 2 acyl carrier protein (ACP) domains to the loading ACP ...
Qiaolin Ji, Chao Peng, Shuhan He, Bin‐Tao Peng, Wei‐Guang Wang, Yudai Matsuda   +5 more
wiley   +2 more sources

One-step Catalyst-Transfer Macrocyclization: Expanding the Chemical Space of Azaparacyclophanes [PDF]

In this paper, we report on a one-step catalyst-transfer macrocyclization (CTM) reaction, based on the Pd-catalyzed Buchwald-Hartwig cross-coupling reaction, selectively affording only cyclic structures.
El Czar, Galleposo, Ruben, Ferreira, Davide, Bonifazi, Pradip Kumar, Mondal, Josue, Ayuso-Carrillo, Federica, Fina, Benjamin D., Ward   +6 more
core   +2 more sources

Macrocyclization of Linear Peptides Enabled by Amphoteric Molecules

, 2016
Macrocyclization of Linear Peptides Enabled by Amphoteric ...
Vishal Rai (2313214), Ryan Hili (1333236), Andrei K. Yudin (1470634)   +2 more
core   +1 more source