Results 41 to 50 of about 5,793 (229)
Synthesis and macrocyclization-induced emission enhancement of benzothiadiazole-based macrocycle
Nature Communications, 2022 Organic luminescent materials attract attention due to their wide application range, but many organic luminogens suffer from severe quenching effect in the aggregate state.
Shuo Li +9 more
doaj +1 more source
Peptide Macrocyclization via Cu-catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides [PDF]
Cyclic peptides are highly valued synthetic targets in organic and medicinal chemistry. The development of new synthetic methodologies for peptide macrocyclization, different from classical lactamization, is essential for the progress of the field ...
Francisco Javier, Adrio +4 more
core +1 more source
Macrocyclization via Allyl Transfer: Total Synthesis of Laulimalide [PDF]
, 2016 Macrocyclization via Allyl Transfer: Total Synthesis of ...
Johann Mulzer (1297377) +2 more
core +1 more source
Beilstein Journal of Organic Chemistry, 2010 Two procedures for the synthesis of benzo-21-crown-7 have been explored. The [1+1] macrocyclization with KBF4 as the template was found to be more efficient than the intramolecular macrocyclization without template.
Wei Jiang, Christoph A. Schalley
doaj +1 more source
Ring-Closing Metathesis Approaches towards the Total Synthesis of Rhizoxins
Molecules, 2020 Efforts are described towards the total synthesis of the bacterial macrolide rhizoxin F, which is a potent tubulin assembly and cancer cell growth inhibitor. A significant amount of work was expanded on the construction of the rhizoxin core macrocycle by
Marc Liniger +2 more
doaj +1 more source
Macrocyclization of Linear Peptides Enabled by Amphoteric Molecules [PDF]
, 2016 Macrocyclization of Linear Peptides Enabled by Amphoteric ...
Vishal Rai (2313214) +2 more
core +1 more source
Macrocyclization Reactions at High Concentration (≥0.2M): The Role of Catalysis [PDF]
, 2023 The synthesis of macrocycles is fundamental to obtain useful quantities of this unique family of organic compounds. However, most current syntheses still require highly diluted conditions (generally < 0.1M), which makes the synthesis extremely ...
Antonio Leyva-Pérez +3 more
core +1 more source
Nature Communications, 2023 Interest in macrocycles as potential therapeutic agents has increased rapidly. Macrocyclization of bioactive acyclic molecules provides a potential avenue to yield novel chemical scaffolds, which can contribute to the improvement of the biological ...
Yanyan Diao +15 more
doaj +1 more source
Marine Drugs, 2018 An N-methylated analog of a marine bacteria-derived natural proline-rich tetracyclopeptide was synthesized by coupling the deprotected dipeptide fragments Boc-l-prolyl-l-N-methylleucine-OH and l-prolyl-l-N-methylphenylalanine-OMe. A coupling reaction was
Rajiv Dahiya +8 more
doaj +1 more source
Synthesis of Lactam-Bridged and Lipidated Cyclo-Peptides as Promising Anti-Phytopathogenic Agents
Molecules, 2020 Antimicrobial resistance to conventional antibiotics and the limited alternatives to combat plant-threatening pathogens are worldwide problems. Antibiotic lipopeptides exert remarkable membrane activity, which usually is not prone to fast resistance ...
Aldrin V. Vasco +5 more
doaj +1 more source