Oxidative Carbocation Formation in Macrocycles: Synthesis of the Neopeltolide Macrocycle [PDF]
Angewandte Chemie, 2009 AbstractMakrocyclische Oxocarbeniumionen wurden aus Makrolactonen mit Benzyl‐ oder Allyletherfunktionen durch oxidative C‐H‐Bindungsaktivierung in Gegenwart von 2,3‐Dichlor‐4,5‐dicyanchinon (DDQ) erhalten. Die Nützlichkeit dieser effizienten Reaktion für die Synthese komplexer Moleküle wurde anhand ihrer Verwendung zum Aufbau des Tetrahydropyronrings ...
Wangyang, Tu, Paul E, Floreancig
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Cyclo‐Polyproline: Chameleonic All‐Peptide Macrocycles With Induced‐Fit Host‐Guest Recognition
Angewandte Chemie, EarlyView.Macrocycles served as the genesis of supramolecular chemistry, advancing synthetic, separation, and materials fields. Despite their utility, they typically lack synthetic control. This work establishes a robust platform for all‐peptide macrocycles capable of host‐guest complexation and chameleonic behavior.
Camilla Di Girolamo +9 more
wiley +2 more sources
Recent Reports of Solid-Phase Cyclohexapeptide Synthesis and Applications
Molecules, 2018 Macrocyclic peptides are privileged scaffolds for drug development and constitute a significant portion of macrocyclic drugs on the market today in fields spanning from infectious disease to oncology.
Allan M. Prior +3 more
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A Convergent Synthesis of the Macrocyclic Core of Cytotrienins: Application of RCM for Macrocyclization [PDF]
Organic Letters, 2004 AbstractFor Abstract see ChemInform Abstract in Full Text.
Evano, Gwilherm, Schaus, JV, Panek, JS
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First synthesis of cryptands with sucrose scaffold
Beilstein Journal of Organic Chemistry, 2019 Cryptands with sucrose scaffold, an unknown class of such derivatives, were prepared from the readily available 2,3,3’,4,4’-penta-O-benzylsucrose and 1’,2,3,3’,4,4’-hexa-O-benzylsucrose.
Patrycja Sokołowska +2 more
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Synthesis of Highly Functionalized Macrocycles by the Peripheral Functionalization of Macrocyclic Diimines [PDF]
The Journal of Organic Chemistry, 2006 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Miguel A, Sierra +4 more
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Catalytic macrocyclization of unactivated C(sp3)-H bond in natural product synthesis
Tetrahedron Green ChemMacrocyclic natural products present as essential scaffolds in drug development. Excited by the biological properties of macrocyclic natural products, its synthesis and the development of macrocyclization methods is an important research area in organic ...
Zhuo Wang
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Synthesis of novel sulfide-based cyclic peptidomimetic analogues to solonamides
Beilstein Journal of Organic Chemistry, 2019 Eight new sulfide-based cyclic peptidomimetic analogues of solonamides A and B have been synthesized via solid-phase peptide synthesis and SN2’ reaction on a Morita–Baylis–Hillman (MBH) residue introduced at the N-terminal of a tetrapeptide.
José Brango-Vanegas +7 more
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Macrocyclic Inhibitors of Hsp90 [PDF]
Current Topics in Medicinal Chemistry, 2010 Heat shock proteins (HSP) are a family of highly conserved proteins, whose expression increases in response to stresses that may threaten cell survival. Over the past decade, heat shock protein 90 (Hsp90) has emerged as a potential therapeutic target for cancer as it plays a vital role in normal cell maturation and acts as a molecular chaperone for ...
Johnson, V +4 more
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From Target-Oriented to Motif-Oriented: A Case Study on Nannocystin Total Synthesis
Molecules, 2020 Natural product total synthesis is in essence target-oriented in that a set of organic transformations are orchestrated into a workable process, leading ultimately to the target molecule with a predefined architecture.
Weicheng Zhang
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