Results 21 to 30 of about 5,793 (229)
Azumamides A-E: Isolation, Synthesis, Biological Activity, and Structure–Activity Relationship
Molecules, 2022 Cyclic peptides are one of the important chemical groups in the HDAC inhibitor family. Following the success of romidepsin in the clinic, naturally occurring cyclic peptides with a hydrophilic moiety have been intensively studied to test their function ...
Sooheum Jo +4 more
doaj +1 more source
Recent Reports of Solid-Phase Cyclohexapeptide Synthesis and Applications
Molecules, 2018 Macrocyclic peptides are privileged scaffolds for drug development and constitute a significant portion of macrocyclic drugs on the market today in fields spanning from infectious disease to oncology.
Allan M. Prior +3 more
doaj +1 more source
Efficient Kinetic Macrocyclization [PDF]
, 2016 In this article, the highly efficient formation of a series of recently discovered aromatic oligoamide macrocycles consisting of six meta-linked residues is first discussed. The macrocycles, with their backbones rigidified by three-center hydrogen bonds,
Liuqing Yang (128705) +8 more
core +1 more source
Pharmaceuticals, 2023 Kinases play an important role in regulating various intracellular signaling pathways that control cell proliferation, differentiation, survival, and other cellular processes, and their deregulation causes more than 400 diseases.
Swapnil P. Bhujbal, Jung-Mi Hah
doaj +1 more source
First synthesis of cryptands with sucrose scaffold
Beilstein Journal of Organic Chemistry, 2019 Cryptands with sucrose scaffold, an unknown class of such derivatives, were prepared from the readily available 2,3,3’,4,4’-penta-O-benzylsucrose and 1’,2,3,3’,4,4’-hexa-O-benzylsucrose.
Patrycja Sokołowska +2 more
doaj +1 more source
Symmetric Macrocycles by a Prins Dimerization and Macrocyclization Strategy [PDF]
Organic Letters, 2009 A tandem dimerization/macrocyclization reaction utilizing the Prins cyclization has been developed. This reaction develops molecular complexity through the formation of highly substituted dimeric tetrahydropyran macrocycles. Mild conditions utilizing rhenium(VII) catalysts were explored for aromatic substrates, while harsher Lewis acidic conditions ...
Michael R, Gesinski +2 more
openaire +2 more sources
Synthesis of novel sulfide-based cyclic peptidomimetic analogues to solonamides
Beilstein Journal of Organic Chemistry, 2019 Eight new sulfide-based cyclic peptidomimetic analogues of solonamides A and B have been synthesized via solid-phase peptide synthesis and SN2’ reaction on a Morita–Baylis–Hillman (MBH) residue introduced at the N-terminal of a tetrapeptide.
José Brango-Vanegas +7 more
doaj +1 more source
Syntheses of Acyclic and Macrocyclic Compounds Derived from 9,9‐Diethylfluorene (Part I)
ChemistryOpen, 2020 A series of new 9,9‐diethylfluorenes consisting of three side‐arms each bearing a heterocyclic, bis(carboxymethyl)amino, bis(carbamoylmethyl)amino, bis(ethoxycarbonylmethyl)amino or an amino group were prepared on the basis of 2,4,7‐tris(bromomethyl)‐9,9‐
Pierre Seidel, Prof. Dr. Monika Mazik
doaj +1 more source
Angewandte Chemie, EarlyView.An optimized strategy for the ribosomal synthesis of thioisoindole‐bridged bicyclic (TiB) peptides is incorporated into the RaPID platform, enabling high‐throughput discovery from topologically defined TiB libraries. Proof‐of‐concept selection against TNIK identifies nanomolar‐affinity ligands with inhibitory activity, while x‐ray crystallography ...
Yue Zhang +5 more
wiley +2 more sources
Marine Drugs, 2016 A natural heptacyclopeptide, stylissamide G (7), previously isolated from the Bahamian marine sponge Stylissa caribica from the Caribbean Sea, was synthesized via coupling of the tetrapeptide l-phenylalanyl-l-prolyl-l-phenylalanyl-l-proline methyl ester ...
Rajiv Dahiya +4 more
doaj +1 more source