Results 11 to 20 of about 6,559 (227)
Nature CommunicationsHerein, an electro-induced umpolung approach that enables the efficient functionalization/macrocyclization of cysteine-containing peptides is reported. Notably, this method utilizes simple halogen source and takes metal-mediated halogen atom transfer as ...
Jia Deng +6 more
core +2 more sources
Total Synthesis of Xentrivalpeptide A and Its 6α-<i>epi</i> Derivative. [PDF]
MoleculesWe report the first total synthesis of xentrivalpeptide A, a cyclic heptadepsipeptide natural product, through a convergent solution-phase strategy. The linear macrocyclization precursor was assembled from two peptide fragments, and a key DEPBT-mediated ...
Hur J, Lee Y.
europepmc +2 more sources
Synthesis of Large- and Medium-Sized Heterobiaryl Atropisomeric Rings and Atropopeptides by Catalytic Intramolecular S<sub>N</sub>Ar. [PDF]
Angew Chem Int Ed EnglCatalytic, intramolecular N‐heterocycle arylation by nucleophilic aromatic substitution (SNAr) is now available for synthesis of highly strained macrocycles and medium‐sized heterobiaryl atropisomeric rings, including atropopeptides. Key to the approach is the ability to generate a strong base catalytically, taking advantage of base‐embedding ...
Kejani AA +7 more
europepmc +2 more sources
A Stepwise Approach to 1,4,10,13-Tetraaza-18-Crown-6 Ether. [PDF]
ChemistryOpenA two‐step approach to the synthesis of tetraaza‐18‐crown‐6 ether was evaluated to address the limitations of the currently used one‐step macrocyclization, such as low yield due to substantial side product formation.
Troosters P +3 more
europepmc +2 more sources
Molbank, 2023 Copper(I)-catalyzed azide-alkyne cycloaddition was employed to construct biscalixarene assemblies from the calix[4]arene dipropargyl ethers and 4,4′-bis-azidomethylated azobenzene or stilbene.
Ivan Lentin +6 more
doaj +1 more source
Spontaneous and Selective Macrocyclization in Nitroaldol Reaction Systems [PDF]
, 2023 Through a dynamic polymerization and self-sorting process, a range of lowellane macrocycles have been efficiently generated in nitroaldol systems composed of aromatic dialdehydes and aliphatic or aromatic dinitroalkanes. All identified macrocycles show a
Mubarak, Ayinla +3 more
core +2 more sources
Substrate-Dependent Crosslinking by the Cytochrome P450 From Aminopyruvatide Biosynthesis. [PDF]
Angew Chem Int Ed EnglSubstitutions in the aminopyruvatide precursor peptide altered the C─C linkage formed from a YLY motif by the P450 ApyO to a N─C linkage in a WLY motif. Moreover, constitutional isomers crosslinked by C─C and C─O linkages were formed from YYY or YWY motifs. ABSTRACT Cytochrome P450s catalyze an array of reactions including crosslinking of aromatic side
Padhi C +6 more
europepmc +3 more sources
Genetic Encoding of Cyanopyridylalanine for In-Cell Protein Macrocyclization by the Nitrile-Aminothiol Click Reaction [PDF]
, 2021 Cyanopyridylalanines are non-canonical amino acids that react with aminothiol compounds under physiological conditions in a biocompatible manner without requiring added catalyst.
Colin, Jackson +7 more
core +1 more source
Synthesis and Biological Activities of Cyclodepsipeptides of Aurilide Family from Marine Origin
Marine Drugs, 2021 Aurilides are a class of depsipeptides occurring mainly in marine cyanobacteria. Members of the aurilide family have shown to exhibit strong cytotoxicity against various cancer cell lines.
Synthia Michon +2 more
doaj +1 more source
Indole-Based Macrocyclization by Metal-Catalyzed Approaches
Organics, 2023 This review is dedicated to the different varieties of macrocycles synthesis bearing indole units in their architecture by metal-catalyzed strategies.
Subba Rao Cheekatla +4 more
doaj +1 more source