Results 11 to 20 of about 3,332 (181)
Structural basis of ribosomal peptide macrocyclization in plants
eLife, 2018 Constrained, cyclic peptides encoded by plant genes represent a new generation of drug leads. Evolution has repeatedly recruited the Cys-protease asparaginyl endopeptidase (AEP) to perform their head-to-tail ligation. These macrocyclization reactions use
Joel Haywood +7 more
doaj +1 more source
Applied Sciences, 2022 The study’s aim was to synthesize new unsymmetrical sulfanyl zinc(II) porphyrazines and subject them to physicochemical and electrochemical characterization and also an initial acute toxicity assessment.
Patrycja Koza +3 more
doaj +1 more source
Kinetic Analysis for Macrocyclizations Involving Anionic Template at the Transition State
The Scientific World Journal, 2012 Several kinetic models for the macrocyclization of a C2 pseudopeptide with a dihalide through a SN2 reaction have been developed. These models not only focus on the kinetic analysis of the main macrocyclization reaction, but also consider the competitive
Vicente Martí-Centelles +2 more
doaj +1 more source
Marine Drugs, 2016 A natural heptacyclopeptide, stylissamide G (7), previously isolated from the Bahamian marine sponge Stylissa caribica from the Caribbean Sea, was synthesized via coupling of the tetrapeptide l-phenylalanyl-l-prolyl-l-phenylalanyl-l-proline methyl ester ...
Rajiv Dahiya +4 more
doaj +1 more source
Azumamides A-E: Isolation, Synthesis, Biological Activity, and Structure–Activity Relationship
Molecules, 2022 Cyclic peptides are one of the important chemical groups in the HDAC inhibitor family. Following the success of romidepsin in the clinic, naturally occurring cyclic peptides with a hydrophilic moiety have been intensively studied to test their function ...
Sooheum Jo +4 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2010 Two procedures for the synthesis of benzo-21-crown-7 have been explored. The [1+1] macrocyclization with KBF4 as the template was found to be more efficient than the intramolecular macrocyclization without template.
Wei Jiang, Christoph A. Schalley
doaj +1 more source
Angewandte Chemie, EarlyView.Molecular recognition guest binding can comprehensively modulate photoinduced charge‐transfer dynamics in the cyclophane host, including charge separation and recombination, via coherent superexchange and incoherent hopping. Unlike covalent donor–bridge–acceptor systems, this supramolecular approach avoids tedious syntheses and offers precise tuning of
Xueze Zhao +11 more
wiley +2 more sources
Syntheses of Acyclic and Macrocyclic Compounds Derived from 9,9‐Diethylfluorene (Part I)
ChemistryOpen, 2020 A series of new 9,9‐diethylfluorenes consisting of three side‐arms each bearing a heterocyclic, bis(carboxymethyl)amino, bis(carbamoylmethyl)amino, bis(ethoxycarbonylmethyl)amino or an amino group were prepared on the basis of 2,4,7‐tris(bromomethyl)‐9,9‐
Pierre Seidel, Prof. Dr. Monika Mazik
doaj +1 more source
Non‐Dilute Synthesis of Macrodiolides and Macrotetrolides Enabled by Confinement Catalysis
Angewandte Chemie, EarlyView.Confinement catalysis within a hexameric resorcin[4]arene capsule enables macrolactonization under non‐dilute conditions (up to 0.1 M), overcoming the limitations of high‐dilution protocols (0.1–10 mM). This strategy provides direct access to 18–32‐membered macrodiolides and 26–32‐membered macrotetrolides in one pot and unlocks previously inaccessible ...
Feng‐Yuan Wang +3 more
wiley +2 more sources
Química Nova, 2008 This review presents natural, semi-synthetic and synthetic bioactive macrolactams and their structure-activity relationships when available. For macrolactams in clinical use the advantages and disadvantages in relation to other drugs are presented, and ...
Renata Fontes Prado Faraco +3 more
doaj +1 more source