Results 31 to 40 of about 5,793 (229)
Divergent Synthesis of Möbius and Hückel N‐Heterocycloarenes From a Common Macrocyclic Backbone
Angewandte Chemie, EarlyView.In the divergent synthesis of Möbius and Hückel N‐heterocycloarenes from a common macrocyclic precursor, the annulation reaction dictates topology: Scholl reaction gives Möbius topology, while InCl3‐mediated alkyne annulation gives Hückel topology. The Möbius N‐heterocycloarene is unevenly contorted as revealed by crystal structure, and the Hückel N ...
Han Chen +6 more
wiley +2 more sources
Angewandte Chemie, EarlyView.Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee +5 more
wiley +2 more sources
Conformationally Unbiased Macrocyclization Reactions by Ring Closing Metathesis [PDF]
, 2016 Conformationally Unbiased Macrocyclization Reactions by Ring Closing ...
Klaus Langemann (2972040) +1 more
core +1 more source
Surface-Confined Macrocyclization via Dynamic Covalent Chemistry [PDF]
, 2020 Surface-confined synthesis is a promising approach to build complex molecular nanostructures including macrocycles. However, despite the recent advances in on-surface macrocyclization under ultrahigh vacuum, selective synthesis of monodisperse and ...
Vrkoslav V. +11 more
core +1 more source
Angewandte Chemie, EarlyView.While cysteine is widely employed as a nucleophilic handle for peptide modification, the electrophilicity of the oxidized form, cystine, is rarely exploited. This study describes a mild, photochemical coupling of sulfinate salts with peptide disulfides.
Joshua M. Hammond +7 more
wiley +2 more sources
Catalytic macrocyclization of unactivated C(sp3)-H bond in natural product synthesis
Tetrahedron Green ChemMacrocyclic natural products present as essential scaffolds in drug development. Excited by the biological properties of macrocyclic natural products, its synthesis and the development of macrocyclization methods is an important research area in organic ...
Zhuo Wang
doaj +1 more source
From Target-Oriented to Motif-Oriented: A Case Study on Nannocystin Total Synthesis
Molecules, 2020 Natural product total synthesis is in essence target-oriented in that a set of organic transformations are orchestrated into a workable process, leading ultimately to the target molecule with a predefined architecture.
Weicheng Zhang
doaj +1 more source
One-step Catalyst-Transfer Macrocyclization: Expanding the Chemical Space of Azaparacyclophanes [PDF]
In this paper, we report on a one-step catalyst-transfer macrocyclization (CTM) reaction, based on the Pd-catalyzed Buchwald-Hartwig cross-coupling reaction, selectively affording only cyclic structures.
El Czar, Galleposo +6 more
core +1 more source
Macrocyclization of Fischer Carbene Complexes as an Approach to Cyclophanes [PDF]
, 2016 Macrocyclization of Fischer Carbene Complexes as an Approach to ...
William D. Wulff (1338240) +1 more
core +1 more source
Two-Step Hantzsch Based Macrocyclization Approach for the Synthesis of Thiazole-Containing Cyclopeptides [PDF]
, 2016 Macrocyclization via an efficient high-yielding solid-phase intramolecular thioalkylation reaction is described. The reaction of S-nucleophiles with newly generated N-terminal 4-chloromethyl thiazoles led to the desired macrocyclization products 5 in ...
Jason E. Fenwick (2250076) +2 more
core +3 more sources