Results 31 to 40 of about 6,559 (227)
Química Nova, 2008 This review presents natural, semi-synthetic and synthetic bioactive macrolactams and their structure-activity relationships when available. For macrolactams in clinical use the advantages and disadvantages in relation to other drugs are presented, and ...
Renata Fontes Prado Faraco +3 more
doaj +1 more source
Azumamides A-E: Isolation, Synthesis, Biological Activity, and Structure–Activity Relationship
Molecules, 2022 Cyclic peptides are one of the important chemical groups in the HDAC inhibitor family. Following the success of romidepsin in the clinic, naturally occurring cyclic peptides with a hydrophilic moiety have been intensively studied to test their function ...
Sooheum Jo +4 more
doaj +1 more source
Recent Reports of Solid-Phase Cyclohexapeptide Synthesis and Applications
Molecules, 2018 Macrocyclic peptides are privileged scaffolds for drug development and constitute a significant portion of macrocyclic drugs on the market today in fields spanning from infectious disease to oncology.
Allan M. Prior +3 more
doaj +1 more source
Non‐Buckling Stacks of Nanocarbon Molecules
Angewandte Chemie, EarlyView.A nanometer‐sized nanocarbon molecule with a central octagon was synthesized by optimizing a tetrameric macrocyclization via concentration‐dependent yield analysis (CYAN). The slightly contorted molecular structure was found to be frozen in a dimeric stack in solution, whereas dissociation into monomers liberated the molecule to undergo buckling ...
Koki Ikemoto +8 more
wiley +2 more sources
Syntheses of Acyclic and Macrocyclic Compounds Derived from 9,9‐Diethylfluorene (Part I)
ChemistryOpen, 2020 A series of new 9,9‐diethylfluorenes consisting of three side‐arms each bearing a heterocyclic, bis(carboxymethyl)amino, bis(carbamoylmethyl)amino, bis(ethoxycarbonylmethyl)amino or an amino group were prepared on the basis of 2,4,7‐tris(bromomethyl)‐9,9‐
Pierre Seidel, Prof. Dr. Monika Mazik
doaj +1 more source
, 2016 Macrocyclization via an efficient high-yielding solid-phase intramolecular thioalkylation reaction is described. The reaction of S-nucleophiles with newly generated N-terminal 4-chloromethyl thiazoles led to the desired macrocyclization products 5 in ...
Jason E. Fenwick (2250076) +2 more
core +2 more sources
Multicopper Clusters Catalyze the Oxidative Phenol Macrocyclization (OxPM) of Linear Peptides [PDF]
, 2023 The biosynthesis of glycopeptide antibiotics such as vancomycin and other biologically active biaryl-bridged and diaryl ether-linked macrocyclic peptides includes key enzymatic oxidative phenol macrocyclization(s) of linear precursors.
Mor, Ben-Lulu +8 more
core +1 more source
Noncanonical Peloruside A Biosynthesis by an Uncultivated Verrucomicrobiota Symbiont
Angewandte Chemie, EarlyView.Noncanonical biochemistry of the peloruside PKS characterized in this work, comprising double bond generation by a noncanonical tridomain (blue), acetyl‐CoA recycling (orange), and proofreading systems (purple and yellow). The Z‐double bond is installed by TEB1 through O‐acetylation and acetate elimination. The acyl ligase PelB (AL, orange) selectively
Amy E. Fraley +11 more
wiley +2 more sources
First synthesis of cryptands with sucrose scaffold
Beilstein Journal of Organic Chemistry, 2019 Cryptands with sucrose scaffold, an unknown class of such derivatives, were prepared from the readily available 2,3,3’,4,4’-penta-O-benzylsucrose and 1’,2,3,3’,4,4’-hexa-O-benzylsucrose.
Patrycja Sokołowska +2 more
doaj +1 more source
Synthesis of novel sulfide-based cyclic peptidomimetic analogues to solonamides
Beilstein Journal of Organic Chemistry, 2019 Eight new sulfide-based cyclic peptidomimetic analogues of solonamides A and B have been synthesized via solid-phase peptide synthesis and SN2’ reaction on a Morita–Baylis–Hillman (MBH) residue introduced at the N-terminal of a tetrapeptide.
José Brango-Vanegas +7 more
doaj +1 more source