Results 31 to 40 of about 3,332 (181)

Synthesis and macrocyclization-induced emission enhancement of benzothiadiazole-based macrocycle

Nature Communications, 2022
Organic luminescent materials attract attention due to their wide application range, but many organic luminogens suffer from severe quenching effect in the aggregate state.
Shuo Li, Kun Liu, Xue-Chen Feng, Zhao-Xian Li, Zhi-Yuan Zhang, Bin Wang, Minjie Li, Yue-Ling Bai, Lei Cui, Chunju Li   +9 more
doaj   +1 more source

Ring-Closing Metathesis Approaches towards the Total Synthesis of Rhizoxins

Molecules, 2020
Efforts are described towards the total synthesis of the bacterial macrolide rhizoxin F, which is a potent tubulin assembly and cancer cell growth inhibitor. A significant amount of work was expanded on the construction of the rhizoxin core macrocycle by
Marc Liniger, Christian M. Neuhaus, Karl-Heinz Altmann   +2 more
doaj   +1 more source

Macrocyclization of linear molecules by deep learning to facilitate macrocyclic drug candidates discovery

Nature Communications, 2023
Interest in macrocycles as potential therapeutic agents has increased rapidly. Macrocyclization of bioactive acyclic molecules provides a potential avenue to yield novel chemical scaffolds, which can contribute to the improvement of the biological ...
Yanyan Diao, Dandan Liu, Huan Ge, Rongrong Zhang, Kexin Jiang, Runhui Bao, Xiaoqian Zhu, Hongjie Bi, Wenjie Liao, Ziqi Chen, Kai Zhang, Rui Wang, Lili Zhu, Zhenjiang Zhao, Qiaoyu Hu, Honglin Li   +15 more
doaj   +1 more source

Toward the Synthesis and Improved Biopotential of an N-methylated Analog of a Proline-Rich Cyclic Tetrapeptide from Marine Bacteria

Marine Drugs, 2018
An N-methylated analog of a marine bacteria-derived natural proline-rich tetracyclopeptide was synthesized by coupling the deprotected dipeptide fragments Boc-l-prolyl-l-N-methylleucine-OH and l-prolyl-l-N-methylphenylalanine-OMe. A coupling reaction was
Rajiv Dahiya, Suresh Kumar, Sukhbir Lal Khokra, Sheeba Varghese Gupta, Vijaykumar B. Sutariya, Deepak Bhatia, Ajay Sharma, Shamjeet Singh, Sandeep Maharaj   +8 more
doaj   +1 more source

Synthesis of Lactam-Bridged and Lipidated Cyclo-Peptides as Promising Anti-Phytopathogenic Agents

Molecules, 2020
Antimicrobial resistance to conventional antibiotics and the limited alternatives to combat plant-threatening pathogens are worldwide problems. Antibiotic lipopeptides exert remarkable membrane activity, which usually is not prone to fast resistance ...
Aldrin V. Vasco, Martina Brode, Yanira Méndez, Oscar Valdés, Daniel G. Rivera, Ludger A. Wessjohann   +5 more
doaj   +1 more source

Small Natural Cyclic Peptides from DBAASP Database

Pharmaceuticals
Antimicrobial peptides (AMPs) are promising tools for combating microbial resistance. However, their therapeutic potential is hindered by two intrinsic drawbacks—low target affinity and poor in vivo stability.
Evgenia Alimbarashvili, Natia Samsonidze, Maia Grigolava, Malak Pirtskhalava   +3 more
doaj   +1 more source

Unprotected peptide macrocyclization and stapling via a fluorine-thiol displacement reaction

Nature Communications, 2022
Strategies capable of stapling unprotected peptides in a straightforward, chemoselective, and clean manner, as well as promoting cellular uptake are of great interest.
Md Shafiqul Islam, Samuel L. Junod, Si Zhang, Zakey Yusuf Buuh, Yifu Guan, Mi Zhao, Kishan H. Kaneria, Parmila Kafley, Carson Cohen, Robert Maloney, Zhigang Lyu, Vincent A. Voelz, Weidong Yang, Rongsheng E. Wang   +13 more
doaj   +1 more source

A Stretchable, Mechanically‐Interlocked Polyrotaxane Hydrogel for Wearable Motion and Electrophysiological Monitoring

Advanced Science, EarlyView.
A mechanically interlocked polyrotaxane hydrogel integrates sliding macrocycles within a covalent network, yielding skin‑like softness, high stretchability, robust adhesion, and stable ionic conductivity. This multifunctional interface enables simultaneous high‑fidelity monitoring of human motion and epidermal electrophysiological signals (ECG/EMG ...
Hao‐Zheng Huang, Yu‐Tao Zheng, Feng Chen, Jing‐Yi Li, Wen‐Hui Zhang, Liang Ding, Zhegang Huang, Wei Jiang, Li‐Ping Huang, Xing‐Can Shen   +9 more
wiley   +1 more source

Magnesium(II) Porphyrazine with Thiophenylmethylene Groups-Synthesis, Electrochemical Characterization, UV–Visible Titration with Palladium Ions, and Density Functional Theory Calculations

Molecules
The presented studies aimed to evaluate the peripheral coordinating properties of a novel porphyrinoid family representative preceded by its synthesis for potential sensing purposes.
Wojciech Szczolko, Kyrylo Chornovolenko, Jacek Kujawski, Zbigniew Dutkiewicz, Tomasz Koczorowski   +4 more
doaj   +1 more source

Nitro-Grela-type complexes containing iodides – robust and selective catalysts for olefin metathesis under challenging conditions

Beilstein Journal of Organic Chemistry, 2015
Iodide-containing nitro-Grela-type catalysts have been synthesized and applied to ring closing metathesis (RCM) and cross metathesis (CM) reactions. These new catalysts have exhibited improved efficiency in the transformation of sterically, non-demanding
Andrzej Tracz, Mateusz Matczak, Katarzyna Urbaniak, Krzysztof Skowerski   +3 more
doaj   +1 more source