Results 51 to 60 of about 6,559 (227)
From Target-Oriented to Motif-Oriented: A Case Study on Nannocystin Total Synthesis
Molecules, 2020 Natural product total synthesis is in essence target-oriented in that a set of organic transformations are orchestrated into a workable process, leading ultimately to the target molecule with a predefined architecture.
Weicheng Zhang
doaj +1 more source
Macrocyclization via Allyl Transfer: Total Synthesis of Laulimalide
, 2016 Macrocyclization via Allyl Transfer: Total Synthesis of ...
Johann Mulzer (1297377) +2 more
core +1 more source
Synthesis and macrocyclization-induced emission enhancement of benzothiadiazole-based macrocycle
Nature Communications, 2022 Organic luminescent materials attract attention due to their wide application range, but many organic luminogens suffer from severe quenching effect in the aggregate state.
Shuo Li +9 more
doaj +1 more source
Conformationally Unbiased Macrocyclization Reactions by Ring Closing Metathesis
, 2016 Conformationally Unbiased Macrocyclization Reactions by Ring Closing ...
Klaus Langemann (2972040) +1 more
core +1 more source
Advanced Science, EarlyView.Cross‐disciplinary endeavors are blossoming across the broad chemical sciences. This perspective provides a glimpse into the rewarding interdisciplinary journey taken by the Charles Loh research group in pioneering the σ‐hole based catalytic glycosylation strategy.
Charles C. J. Loh
wiley +1 more source
Marine Drugs, 2018 An N-methylated analog of a marine bacteria-derived natural proline-rich tetracyclopeptide was synthesized by coupling the deprotected dipeptide fragments Boc-l-prolyl-l-N-methylleucine-OH and l-prolyl-l-N-methylphenylalanine-OMe. A coupling reaction was
Rajiv Dahiya +8 more
doaj +1 more source
Ring-Closing Metathesis Approaches towards the Total Synthesis of Rhizoxins
Molecules, 2020 Efforts are described towards the total synthesis of the bacterial macrolide rhizoxin F, which is a potent tubulin assembly and cancer cell growth inhibitor. A significant amount of work was expanded on the construction of the rhizoxin core macrocycle by
Marc Liniger +2 more
doaj +1 more source
Nature Communications, 2023 Interest in macrocycles as potential therapeutic agents has increased rapidly. Macrocyclization of bioactive acyclic molecules provides a potential avenue to yield novel chemical scaffolds, which can contribute to the improvement of the biological ...
Yanyan Diao +15 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2015 Iodide-containing nitro-Grela-type catalysts have been synthesized and applied to ring closing metathesis (RCM) and cross metathesis (CM) reactions. These new catalysts have exhibited improved efficiency in the transformation of sterically, non-demanding
Andrzej Tracz +3 more
doaj +1 more source
Synthesis of Lactam-Bridged and Lipidated Cyclo-Peptides as Promising Anti-Phytopathogenic Agents
Molecules, 2020 Antimicrobial resistance to conventional antibiotics and the limited alternatives to combat plant-threatening pathogens are worldwide problems. Antibiotic lipopeptides exert remarkable membrane activity, which usually is not prone to fast resistance ...
Aldrin V. Vasco +5 more
doaj +1 more source