Results 51 to 60 of about 5,793 (229)
Unprotected peptide macrocyclization and stapling via a fluorine-thiol displacement reaction
Nature Communications, 2022 Strategies capable of stapling unprotected peptides in a straightforward, chemoselective, and clean manner, as well as promoting cellular uptake are of great interest.
Md Shafiqul Islam +13 more
doaj +1 more source
Advanced Materials, EarlyView.Fully recombinant protein‐based biomaterials execute complex Boolean logic for user‐programmable material degradation and concomitant therapeutic cargo release. Biologics, such as growth factors, can be incorporated within the crosslinkers as “drugamers”, while encapsulated cells can be released according to nested YES/OR/AND‐type logical operations ...
Murial L. Ross +3 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2015 Iodide-containing nitro-Grela-type catalysts have been synthesized and applied to ring closing metathesis (RCM) and cross metathesis (CM) reactions. These new catalysts have exhibited improved efficiency in the transformation of sterically, non-demanding
Andrzej Tracz +3 more
doaj +1 more source
Self-cyclisation as a general and efficient platform for peptide and protein macrocyclisation
Communications Chemistry, 2023 Head-to-tail macrocyclization of proteins and peptides can increase their structural stability, however, potential polymerization can lead to reduced yields.
Xinying Jia +10 more
doaj +1 more source
Advanced Science, EarlyView.Cross‐disciplinary endeavors are blossoming across the broad chemical sciences. This perspective provides a glimpse into the rewarding interdisciplinary journey taken by the Charles Loh research group in pioneering the σ‐hole based catalytic glycosylation strategy.
Charles C. J. Loh
wiley +1 more source
Macrocyclization of Unprotected Peptide Isocyanates [PDF]
, 2016 A chemistry for the facile two-component macrocyclization of unprotected peptide isocyanates is described. Starting from peptides containing two glutamic acid γ-hydrazide residues, isocyanates can be readily accessed and cyclized with hydrazides of ...
Bradley L. Pentelute (1247046) +3 more
core +1 more source
Stereoselective macrocyclization through zirconocene-mediated coupling of achiral dialkynes [PDF]
, 2009 Stereoselective macrocyclization through zirconocene-mediated coupling of achiral ...
Adam D Miller (10997982) +5 more
core +2 more sources
Total Synthesis and Pharmacological Investigation of Cordyheptapeptide A
Molecules, 2017 The present investigation reports the synthesis of a phenylalanine-rich N-methylated cyclopeptide, cordyheptapeptide A (8), previously isolated from the insect pathogenic fungus Cordyceps sp.
Suresh Kumar +5 more
doaj +1 more source
Total Synthesis of (+)-Phomactin A Using a B-Alkyl Suzuki Macrocyclization [PDF]
, 2016 A total synthesis of (+)-phomactin A is described using a B-alkyl Suzuki macrocyclization to incorporate the isolated trisubstituted olefin. This macrocyclization was accomplished with the sensitive hydrated furan ring in place. (R)-(+)-pulegone was used
Peter J. Mohr (1706467) +1 more
core +3 more sources
Small Natural Cyclic Peptides from DBAASP Database
PharmaceuticalsAntimicrobial peptides (AMPs) are promising tools for combating microbial resistance. However, their therapeutic potential is hindered by two intrinsic drawbacks—low target affinity and poor in vivo stability.
Evgenia Alimbarashvili +3 more
doaj +1 more source