Results 71 to 80 of about 5,793 (229)
Chemistry – A European Journal, EarlyView.Chemoenzymatic reactions using the siderophore synthetase DesD from Salinispora tropica and hydroxamic acid substrates (native, non‐native) with different multiplicities (monomer, dimer) and components (homo‐/heterodimer) followed different reaction trajectories, which biased the architectures of the chelator major products and indicated DesD contains ...
Callum A. Rosser +2 more
wiley +1 more source
Solid-Phase SN2 Macrocyclization Reactions To Form β-Turn Mimics [PDF]
, 2016 Efficient solid-phase SN2 macrocyclization reactions were sought to facilitate preparations of focused libraries of β-turn mimetics. A very efficient, but undesired, cyclization reaction to give five-membered ring lactams 4 was identified in attempts to ...
Zhicheng Wang (453756) +3 more
core +1 more source
Chemistry – A European Journal, EarlyView.This is a comprehensive study of new family of high functionalized meso‐tetraarylporphyrins. A synthetic approach to phosphonate‐substituted fluorinated porphyrins was developed. These compounds were investigated with respect to singlet oxygen generation and photostability.
Azhar Kechiche +8 more
wiley +1 more source
Stepwise Synthesis of Tetrabenzotriazaporphyrins (TBTAPs) and Their Open 2‐ and 3‐Ring Fragments
Chemistry – A European Journal, EarlyView.Unexpected reaction pathways to porphyrin‐phthalocyanine hybrids are uncovered by the synthesis of “half‐macrocycle” fragments and subsequent macrocyclization. Rather than the expected 2:2 “ABBA” product, the 3:1 “ABBB” hybrid is isolated as the only macrocyclic product.
Jacob Gretton +10 more
wiley +1 more source
Non‐Dilute Synthesis of Macrodiolides and Macrotetrolides Enabled by Confinement Catalysis
Angewandte Chemie, Volume 138, Issue 34, 17 August 2026.Confinement catalysis within a hexameric resorcin[4]arene capsule enables macrolactonization under non‐dilute conditions (up to 0.1 M), overcoming the limitations of high‐dilution protocols (0.1–10 mM). This strategy provides direct access to 18–32‐membered macrodiolides and 26–32‐membered macrotetrolides in one pot and unlocks previously inaccessible ...
Feng‐Yuan Wang +3 more
wiley +2 more sources
Relay Approach: A Convergent Synthesis of Key Fragments en route to (+)‐Neosorangicin A
Chemistry – A European Journal, EarlyView.A selective synthesis of three key fragments of the antibiotically active (+)‐neosorangicin A is reported, providing a foundation for its convergent total synthesis and proof of strategy via a relay approach. ABSTRACT Herein, we report the synthesis of the three key fragments of the macrolide antibiotic (+)‐neosorangicin A, a compound exhibiting potent
Marvin Wenninger +6 more
wiley +1 more source
Characterizing and Engineering Thioesterases as Biocatalysts for Macrocyclization [PDF]
Natural products (NP) present themselves as complex molecules with useful and potent biological activities. Notably, macrocyclic NP have garnered significant attention for defying the prototypical "rule of 5" yet retaining optimal pharmacological ...
Brazeau-Henrie, Jordan
core +1 more source
CuAAC Macrocyclization: High Intramolecular Selectivity through the Use of Copper–Tris(triazole) Ligand Complexes [PDF]
, 2016 A range of multivalent heteroaryl ligands, copper sources, and solvent systems have been investigated for use in CuAAC-mediated macrocyclization reactions.
Gagan Chouhan (1980898) +1 more
core +1 more source
A Flow Chemistry Platform for Photochemical Macrocyclization of Peptides [PDF]
The importance of macrocyclic peptides in drug discovery has spawned a variety of modern techniques to improve their synthesis. Although photocatalysis is now an indispensable tool in the synthesis of natural products and pharmaceuticals, it is rarely ...
William Neiderer (11073363) +5 more
core +1 more source
Revisit to ()-Civetone Synthesis
Natural Product Communications, 2012 The synthesis of ( Z )-civetone ( 1 ) is described starting from oleic acid ( 5 ) via a series of reactions, intermolecular olefin self-metathesis, bromination/dehydrobromination into acetylene, semi-hydrogenation and intramolecular Dieckmann ...
Hisahiro Hagiwara +4 more
doaj +1 more source