Results 71 to 80 of about 6,559 (227)
MoleculesThe presented studies aimed to evaluate the peripheral coordinating properties of a novel porphyrinoid family representative preceded by its synthesis for potential sensing purposes.
Wojciech Szczolko +4 more
doaj +1 more source
Total Synthesis of (+)-Phomactin A Using a B-Alkyl Suzuki Macrocyclization
, 2016 A total synthesis of (+)-phomactin A is described using a B-alkyl Suzuki macrocyclization to incorporate the isolated trisubstituted olefin. This macrocyclization was accomplished with the sensitive hydrated furan ring in place. (R)-(+)-pulegone was used
Peter J. Mohr (1706467) +1 more
core +2 more sources
Nature Communications, 2022 Macrocyclization is an important process in bioactive natural product synthesis. Here, the authors report on the study of a macrocyclic ring constructing enzyme in the biosynthesis of alchivemycin A and using gene deletion, biochemical assays and isotope
Hong Jie Zhu +11 more
doaj +1 more source
Thiol-Yne click chemistry of acetylene-enabled macrocyclization
Nature Communications, 2022 Thiol–yne coupling is a reliable method to link two molecular units, but has not been extensively explored for the construction of macrocycles. Here, the authors use gaseous acetylene, the simplest alkyne unit, to synthesize a variety of macrocycles ...
Shiwei Lü, Zipeng Wang, Shifa Zhu
doaj +1 more source
Stereoselective macrocyclization through zirconocene-mediated coupling of achiral dialkynes
, 2009 Stereoselective macrocyclization through zirconocene-mediated coupling of achiral ...
Adam D Miller (10997982) +5 more
core +1 more source
High-Yield Macrocyclization via Glaser Coupling of Temporary Covalent Templated Bisacetylenes
, 2016 High-Yield Macrocyclization via Glaser Coupling of Temporary Covalent Templated ...
Sigurd Höger (40537) +2 more
core +1 more source
, 2018 The long-lasting impetus to design novel modes of macrocyclization, and their implementation into a wide range of bioactive peptides, originates from their contributions to the restriction of conformational space and the stabilization of preferential ...
Paolo Rovero +3 more
core +1 more source
Atroposelective Access to Bicyclic Peptides via an Amide Photocaging Strategy
Angewandte Chemie International Edition, EarlyView.Ansamers are an atypical class of atropisomers (Pansa/Mansa) and stereoselective synthesis of its two conformational isomers is challenging. We introduce a photocaged amide protection strategy: photolabile groups in monocycles reversibly modulate amide geometry, biasing macrolactamization to selectively give Pansa or Mansa.
Haijian Yang +7 more
wiley +1 more source
Total synthesis of the reported structure of ceanothine Dviaa novel macrocyclization strategy
, 2018 A novel regio- and stereocontrolled macrocyclization strategy was developed for the first synthesis of ceanothine D.
Madeleine M. Joullié, Jisun Lee
core +1 more source
, 2022 The development of innovative strategies and methods to provide natural product-like macrocycles not accessible by biosynthesis, but endowed with novel bioactivities and simplified structure, is highly desirable.
Tang, Bixi +8 more
core +1 more source