Results 71 to 80 of about 3,332 (181)

Efficient Synthesis of a Range of Benzosubstituted Macrocyclic Diamides [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2000
Some new macrocyclic dibenzotetraoxadiamides, tribenzotetraoxadimides, tribenzopentaoxadiamide, tribenzohexaoxadiamide, and tetrabenzoheptaoxadiamide 15-22 have been prepared.
Hashem Sharghi, Ahmad Reza Massah, Khodabakhsh Niknam   +2 more
doaj  

Efficient catenane synthesis by cucurbit[6]uril-mediated azide–alkyne cycloaddition

Beilstein Journal of Organic Chemistry, 2018
We report here the efficient synthesis of a series of [3]catenanes featuring the use of cucurbit[6]uril to simultaneously mediate the mechanical and covalent bond formations.
Antony Wing Hung Ng, Chi-Chung Yee, Kai Wang, Ho Yu Au-Yeung   +3 more
doaj   +1 more source

Enantio-, atrop-, and diastereoselective macrolactonization to access type III cyclophanes

Nature Communications
Although chiral substituents have been incorporated into ansa chains to stabilize the conformations of cyclophanes and modulate the biological activities of pharmaceuticals, the asymmetric syntheses of these atropisomers relies on substrate-induced ...
Jiaming Wang, Kang Lv, Yilu Wen, Tao Liu, Changgui Zhao   +4 more
doaj   +1 more source

Design of indole- and MCR-based macrocycles as p53-MDM2 antagonists

Beilstein Journal of Organic Chemistry, 2019
Macrocycles were designed to antagonize the protein–protein interaction p53-MDM2 based on the three-finger pharmacophore F19W23L25. The synthesis was accomplished by a rapid, one-pot synthesis of indole-based macrocycles based on Ugi macrocyclization ...
Constantinos G. Neochoritis, Maryam Kazemi Miraki, Eman M. M. Abdelraheem, Ewa Surmiak, Tryfon Zarganes-Tzitzikas, Beata Łabuzek, Tad A. Holak, Alexander Dömling   +7 more
doaj   +1 more source

Introduction: Macrocycles [PDF]

Chemical Reviews, 2019
openaire   +2 more sources

Carbene organic catalytic planar enantioselective macrolactonization

Nature Communications
Macrolactones exhibit distinct conformational and configurational properties and are widely found in natural products, medicines, and agrochemicals. Up to now, the major effort for macrolactonization is directed toward identifying suitable carboxylic ...
Xiaokang Lv, Fen Su, Hongyan Long, Fengfei Lu, Yukun Zeng, Minghong Liao, Fengrui Che, Xingxing Wu, Yonggui Robin Chi   +8 more
doaj   +1 more source

Structure-guided design of picomolar-level macrocyclic TRPC5 channel inhibitors with antidepressant activity

Acta Pharmaceutica Sinica B
Recent advances in ion channel structural biology have enhanced structure-based drug design, yet lipid-occupied binding pockets—often large and flat—remain a major hurdle for developing selective small molecules.
Tong Che, Yixiang Chen, Xinyu Cheng, Han Hu, Xiaoyun Wu, Yuting Zhang, Xiaoqiang Yang, Yinzhen Liu, Hui Liu, Weiwei Nan, Shuangyan Wan, Mingxing Yang, Bo Zeng, Jian Li, Jin Zhang, Bing Xiong   +15 more
doaj   +1 more source

Macrocyclic colibactins

Nature Chemistry, 2020
openaire   +3 more sources

A CONVENIENT SYNTHESIS OF MACROCYCLIC DIAMIDES [PDF]

Journal of Sciences, Islamic Republic of Iran, 1998
Some new macrocyclic dibenzotrioxadiamides, dibenzotetraoxadiamide, dibenzopentaoxadiamide, dibenzothiatrioxadiamide, tribenzotrioxadiamides and tetrabenzohexaoxadiamide (14-21), (26) and (27) have been prepared.
doaj  

A Versatile Strategy for Head-to-Tail Macrocyclization and Traceless Backbone Editing of Short Peptides. [PDF]

J Am Chem Soc
Wall BJ, Chaudhury U, Sharma KK, Venditti V, VanVeller B.   +4 more
europepmc   +1 more source