Results 81 to 90 of about 5,793 (229)
A STRAIGHTFORWARD SYNTHESIS OF NOVEL 1,3,5-TRIAZINE-BASED MACROCYCLIC SCAFFOLDS
Studia Universitatis Babes-Bolyai Chemia, 2020 The synthesis and structural investigation of a series of three macrocycles bearing 2,4,6-tris(p-phenylene)-1,3,5-triazine central units and oligoethyleneoxide bridges are reported.
Cosmin V. CRIŞAN +4 more
doaj +1 more source
Chemistry – A European Journal, EarlyView.Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley +1 more source
Chemistry – A European Journal, EarlyView.A rapid and efficient protocol for the synthesis of 2‐benzylbenzaldehydes and anthracenes is reported, based on the infrared (IR) irradiation‐assisted Pd‐catalyzed C(sp3)─H arylation and the tandem C(sp3)─H arylation/electrophilic aromatic cyclization of ortho‐tolualdehydes with aryl iodides via a transient directing group (TGD) strategy.
Matteo Renato Martina +6 more
wiley +1 more source
Synthesis of Monothiacalix[4]arene Using the Fragment Condensation Approach
MoleculesThe article describes a simple and scalable preparation of 2-monothiacalix[4]arene 7, the simplest representative of the mixed-bridged (CH2 and S) calix[4]arenes.
Daniel Kortus +7 more
doaj +1 more source
Nature Communications, 2017 Cyclic peptide macrocycles are promising anti-cancer and antimicrobial molecules. Here, the authors characterize the structure and catalytic mechanism of the prolyl oligopeptidase B from Basidiomycete fungi, showing that its dual macrocyclase-peptidase ...
Clarissa M. Czekster +3 more
doaj +1 more source
Retro‐Hetero‐Michael Addition Strategies in Organic Synthesis
European Journal of Organic Chemistry, EarlyView.In this review, synthetic approaches to carbo‐ and heterocyclic compounds, including natural products, published in the last 15 years (2011–2025) which have either relied upon or included a retro‐hetero‐Michael addition step at any stage are discussed.
Dina Scarpi, Ernesto G. Occhiato
wiley +1 more source
The Role of Attractive Non-Covalent Interactions in Peptide Macrocyclization [PDF]
The efficiency of macrocyclization reactions relies on the appropriate conformational preorganization of a linear precursor, ensuring that reactive ends are in spatial proximity prior to ring closure.
George J. Saunders (17783983) +4 more
core +1 more source
CHIMIA, 2011 Macrocyclization methodologies allowing access to macrocycles having an endo aryl ether and an endo aryl–aryl bond, especially those based on an intramolecular SNAr reaction and the Suzuki-Miyaura reaction, are summarized.
Qian Wang, Jieping Zhu
doaj +1 more source
Competing Charge Transport Pathways: A Spirobifluorene‐Based Molecular Loop
European Journal of Organic Chemistry, EarlyView.A rigid molecular loop integrating a spirobifluorene (SBF) core with a cycloparaphenylene (CPP) moiety provides two distinct transport channels. Through‐space spiroconjugation and radial π‐conjugation along a CPP backbone coexist within a single molecule.
Brian Ogi +4 more
wiley +1 more source
Binuclear Copper‐Dependent Oxidative Enzymes Involved in Fungal Natural Product Modifications
Journal of the Chinese Chemical Society, EarlyView.This article summarizes recent biochemical characterizations of a new enzyme family named by the authors as binuclear copper‐dependent oxidative enzymes (BiNCOs). Found in fungal natural product biosynthesis, BiNCOs catalyze diverse CH functionalization reactions, including C(sp3)H halogenation, C(sp3)H hydroxylation, C(sp3)O macrocyclization, and ...
Chen‐Yu Chiang, Masao Ohashi, Yi Tang
wiley +1 more source