Results 81 to 90 of about 6,559 (227)
, 2016 Using Marine Natural Products to Discover a Protease that Catalyzes Peptide Macrocyclization of Diverse ...
John McIntosh (2391958) +3 more
core +1 more source
Observations on the Influence of Precursor Conformations on Macrocyclization Reactions [PDF]
, 2016 Macrocycles hold great promise in drug discovery as an underutilized class of lead compounds. The low abundance of these molecules can, in part, be explained by the inherent difficulties in the synthesis of macrocycles and the lack of general methods for
Clausen, Mads Hartvig +9 more
core +1 more source
Biocatalysts for Peptide Geranylation With Linear and Cyclic Prenyl Groups
Angewandte Chemie International Edition, EarlyView.A combination of genome mining, synthetic biology, and biocatalytic assays revealed enzymes that install linear and cyclized prenyl moieties on ribosomally or chemically synthesized peptides. The promiscuity of both enzymes, while being specific for modification of C‐terminal tryptophans, enables enzymatic access to peptide terpenoid hybrids.
Sarolt Magyari +10 more
wiley +1 more source
Macrocyclization in the Design of Non-Phosphorus-Containing Grb2 SH2 Domain-Binding Ligands
, 2016 Macrocyclization from the phosphotyrosyl (pTyr) mimetic's β-position has previously been shown to enhance Grb2 SH2 domain-binding affinity of phosphonate-based analogues.
Kyeong Lee (1714360) +12 more
core +1 more source
Antimicrobial Peptides and Peptidomimetics in Foods – A Synthetic Foray
ChemFoodChem, EarlyView.This Review discusses AMPs in foods and their syntheses. It espouses facile methods to make them accessible and suggests their utility in the mitigation and eradication of the burgeoning maladies of antimicrobial and multidrug resistance (AMR and MDR).
Josephat U. Izunobi +2 more
wiley +1 more source
Protein Conformational Stability Enhancement Through PEGylation and Macrocyclization
, 2021 PEGylation can improve the pharmacokinetic properties of protein therapeutics via decreasing renal clearance and shielding the protein surface from proteases, antibody neutrailization, and aggregation.
Xiao, Qiang
core
Chemistry – A European Journal, EarlyView.Captured in water. A tetrasulfonated deep‐cavity calix[4]arene encapsulates linear and cyclic alkanes, as well as benzene and hexafluorobenzene, in water by forming a self‐assembled dimeric capsule. The binding affinity is guest size‐dependent. For linear alkanes, the affinity peaks at n‐hexane, while cyclooctane is the most strongly bound cycloalkane.
Nico Schneider +5 more
wiley +1 more source
Application of a macrocyclization strategy in kinase inhibitor development
Acta Materia MedicaKinases have a pivotal role in phosphorylation and kinase dysregulation has been implicated in the occurrence and progression of various diseases. By mid-2024 the Food and Drug Administration had approved 81 small-molecule kinase inhibitors targeting ...
Kun Xing +5 more
doaj +1 more source
C‐Terminal Functionalization Methods of Amino Acids, Peptides, and Proteins
Chemistry – A European Journal, EarlyView.C‐terminal functionalization offers powerful routes to peptide and protein diversification, yet epimerization, hydrolysis, and selectivity remain key challenges. This Review surveys enzymatic, decarboxylative, and condensation strategies, highlighting advances toward chemo‐ and regioselective, protecting‐group‐free, atom‐efficient methods applicable to
Jay Hanssens +3 more
wiley +1 more source
Revisit to ()-Civetone Synthesis
Natural Product Communications, 2012 The synthesis of ( Z )-civetone ( 1 ) is described starting from oleic acid ( 5 ) via a series of reactions, intermolecular olefin self-metathesis, bromination/dehydrobromination into acetylene, semi-hydrogenation and intramolecular Dieckmann ...
Hisahiro Hagiwara +4 more
doaj +1 more source