Results 91 to 100 of about 5,793 (229)

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Catalytic Ni/Cr-Mediated Macrocyclization without Use of High-Dilution Techniques [PDF]

, 2016
The feasibility of catalytic Ni/Cr-mediated macrocyclization was demonstrated for the two substrates chosen from the halichondrin area. With 5 mol % of Ni and Cr catalysts, the macrocyclization was realized without use of high-dilution techniques.
Kosuke Namba (703715), Yoshito Kishi (505169)   +1 more
core   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Cyclic Thiosulfinates: Synthesis and Applications in Chemical Biology and Materials Science

ChemBioChem, Volume 27, Issue 16, 27 August 2026.
Cyclic thiosulfinates (CTs) are strained organosulfur heterocyclic compounds with a polarized ─S(═O)─S─ bond that enables selective thiol reactivity. Advances in synthesis afford tunable scaffolds that support efficient proximal thiol cross‐linking and enable applications in chemical biology and materials science. Cyclic thiosulfinates (CTs) constitute
Benjamin Liebson, Jeffrey N. Agar, Roman Manetsch, Prakash T. Parvatkar   +3 more
wiley   +1 more source

Direct and indirect single electron transfer (SET)-photochemical approaches for the preparation of novel phthalimide and naphthalimide-based lariat-type crown ethers

Beilstein Journal of Organic Chemistry, 2014
In this review, we describe direct and indirect photochemical approaches that have been developed for the preparation of phthalimide- and naphthalimide-based, lariat-type crown ethers.
Dae Won Cho, Patrick S. Mariano, Ung Chan Yoon   +2 more
doaj   +1 more source

High-Yield Macrocyclization via Glaser Coupling of Temporary Covalent Templated Bisacetylenes [PDF]

, 2016
High-Yield Macrocyclization via Glaser Coupling of Temporary Covalent Templated ...
Sigurd Höger (40537), Anne-Désirée Meckenstock (3040689), Heike Pellen (3040686)   +2 more
core   +1 more source

Bacterial Cytochrome P450 Catalyzed Macrocyclization of Ribosomal Peptides [PDF]

ACS Bio & Med Chem Au
Macrocyclization is a vital process in the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), significantly enhancing their structural diversity and biological activity.
Jing Liu, Runze Liu, Bei-Bei He, Xiaoqian Lin, Longcheng Guo, Gengfan Wu, Yong-Xin Li   +6 more
doaj   +2 more sources

Synthesis of β‐Thiolated Amino Acids: Investigation Toward the Total Chemical Synthesis of Lasso Peptide Microcin J25

ChemBioChem, Volume 27, Issue 15, 14 August 2026.
Lasso peptide, Microcin J25 (MccJ25), exhibits extreme stability and potent antibacterial activity against Gram‐negative bacteria due to its rigid “lariat” structure. However, this unique topology precludes researchers to achieve the total chemical synthesis. Herein, we investigated the chemical synthetic prestapling strategy toward synthesis of MccJ25
Yu‐Ting Hsiao, Bethan L. Heard, Ilia Perov, Marco J. van Belkum, Sorina Chiorean, Kaitlyn Towle, Isaac Antwi, John C. Vederas   +7 more
wiley   +1 more source

Improved Incorporation of Arylglycines Into Ramoplanin Sequences via Solid‐Phase Peptide Synthesis

European Journal of Organic Chemistry, Volume 29, Issue 30, 12 August 2026.
The incorporation of arylglycines using solid‐phase peptide synthesis remains challenging due to the sensitivity of these residues for epimerization. Here, exploring multiple conditions for the incorporation of arylglycine residues into peptides using SPPS demonstrates how small changes to current synthesis protocols can lead to significant ...
Edward Marschall, Sam Tucker, Max J. Cryle, Julien Tailhades   +3 more
wiley   +1 more source

Versatile Peptide Macrocyclization with Diels–Alder Cycloadditions [PDF]

, 2019
Macrocyclization can improve bioactive peptide ligands through preorganization of molecular topology, leading to improvement of pharmacologic properties like binding affinity, cell permeability, and metabolic stability.
Jeffrey E. Montgomery (7431203), Xianghang Shangguan (1666126), Geoffrey L. Greene (414201), Justin A. Donnelly (7431206), John S. Coukos (2850401), Raymond E. Moellering (2850404), Thomas E. Speltz (5244893), Sean W. Fanning (2192731)   +7 more
core   +1 more source