Results 91 to 100 of about 6,559 (227)
Trends and Future Directions in Organic Chemistry for Drug Discovery
Chemistry – A European Journal, EarlyView.Organic synthesis is being reshaped by the convergence of catalytic innovation, automation, artificial intelligence, and emerging therapeutic modalities. Late‐stage functionalization, photoredox and electrochemical methods, biocatalysis, flow chemistry, DELs, and proximity‐based drugs are examined as components of closed‐loop discovery.
Paweł Kozyra, Maciej Masłyk
wiley +1 more source
A STRAIGHTFORWARD SYNTHESIS OF NOVEL 1,3,5-TRIAZINE-BASED MACROCYCLIC SCAFFOLDS
Studia Universitatis Babes-Bolyai Chemia, 2020 The synthesis and structural investigation of a series of three macrocycles bearing 2,4,6-tris(p-phenylene)-1,3,5-triazine central units and oligoethyleneoxide bridges are reported.
Cosmin V. CRIŞAN +4 more
doaj +1 more source
, 2016 A formal total synthesis of oximidine II has been achieved, employing a Suzuki-type coupling approach to construct the highly strained, polyunsaturated 12-membered macrolactone.
Gary A. Molander (1314150) +1 more
core +1 more source
Chemistry – A European Journal, EarlyView.The integrated experimental‐computational study on the asymmetric activation exerted by isohexides on tropos tetra‐aryl moieties embedded in a chiral macrocyclic architecture resulted in a complete definition of the stereochemical as well as stereodynamic features of the macrocyclic final compounds.
Giuseppe Fulvetti +3 more
wiley +1 more source
Synthesis of Monothiacalix[4]arene Using the Fragment Condensation Approach
MoleculesThe article describes a simple and scalable preparation of 2-monothiacalix[4]arene 7, the simplest representative of the mixed-bridged (CH2 and S) calix[4]arenes.
Daniel Kortus +7 more
doaj +1 more source
Nature Communications, 2017 Cyclic peptide macrocycles are promising anti-cancer and antimicrobial molecules. Here, the authors characterize the structure and catalytic mechanism of the prolyl oligopeptidase B from Basidiomycete fungi, showing that its dual macrocyclase-peptidase ...
Clarissa M. Czekster +3 more
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Medicinal Research Reviews, EarlyView.ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley +1 more source
CHIMIA, 2011 Macrocyclization methodologies allowing access to macrocycles having an endo aryl ether and an endo aryl–aryl bond, especially those based on an intramolecular SNAr reaction and the Suzuki-Miyaura reaction, are summarized.
Qian Wang, Jieping Zhu
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Small, EarlyView.Tunable nano‐twisted structures of novel isomeric macrocycles, which were controlled by cis/trans isomerizations of stiff‐stilbene units under light irradiations, have been exploited to modulate bent and planar configurations of 9,14‐diphenyl‐9,14‐dihydrodibenzo[a,c]phenazine (DPAC) moieties and adjust their ratiometric emissions. External factors, i.e.
Nguyen Thanh Trung +11 more
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Chemistry – A European Journal, Volume 32, Issue 41, 3 November 2026.A rapid and efficient protocol for the synthesis of 2‐benzylbenzaldehydes and anthracenes is reported, based on the infrared (IR) irradiation‐assisted Pd‐catalyzed C(sp3)─H arylation and the tandem C(sp3)─H arylation/electrophilic aromatic cyclization of ortho‐tolualdehydes with aryl iodides via a transient directing group (TGD) strategy.
Matteo Renato Martina +6 more
wiley +1 more source