Results 111 to 120 of about 6,559 (227)

Characterizing and Engineering Thioesterases as Biocatalysts for Macrocyclization [PDF]

Natural products (NP) present themselves as complex molecules with useful and potent biological activities. Notably, macrocyclic NP have garnered significant attention for defying the prototypical "rule of 5" yet retaining optimal pharmacological ...
Brazeau-Henrie, Jordan
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Theoretical Studies on the Catalytic Mechanism and Substrate Diversity for Macrocyclization of Pikromycin Thioesterase

, 2018
Polyketide synthases (PKSs) share a subset of biosynthetic steps in construction of a polyketide, and the offload from the PKS main module of specific product release is most often catalyzed by a thioesterase (TE).
Xiao-Lei Wang (306055), Linquan Bai (331158), Yi-Lei Zhao (800876), Shuobing Fan (5100317), Shenggan Luo (5100326), Ting Shi (3955), Lanxuan Liu (5100323), Wentao Tao (5100320)   +7 more
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Pd(OAc)₂‑Catalyzed Macrocyclization of 1,2-Diazo­naphtho­quinones with Cyclic Ethers

, 2016
Pd­(OAc)2 was found to be an efficient catalyst for the macrocyclization of 1,2-diazo­naphtho­quinones and cyclic ethers.
Mitsuru Kitamura (1545862), Masato Kisanuki (1830979), Tatsuo Okauchi (1545856), Koichi Kanemura (1830976)   +3 more
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Efficient Synthesis of a Range of Benzosubstituted Macrocyclic Diamides [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2000
Some new macrocyclic dibenzotetraoxadiamides, tribenzotetraoxadimides, tribenzopentaoxadiamide, tribenzohexaoxadiamide, and tetrabenzoheptaoxadiamide 15-22 have been prepared.
Hashem Sharghi, Ahmad Reza Massah, Khodabakhsh Niknam   +2 more
doaj  

Pinacol Macrocyclization-Based Route to the Polyfused Medium-Sized CDE Ring System of Lancifodilactone G

, 2016
The polyfused medium-sized CDE ring system of lancifodilactone G is assembled via B-alkyl Suzuki−Miyaura cross-coupling and SmI2-mediated pinacol macrocyclization as the key strategic ...
Kwong Wah Lai (2421373), Leo A. Paquette (2352241)   +1 more
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Enantio-, atrop-, and diastereoselective macrolactonization to access type III cyclophanes

Nature Communications
Although chiral substituents have been incorporated into ansa chains to stabilize the conformations of cyclophanes and modulate the biological activities of pharmaceuticals, the asymmetric syntheses of these atropisomers relies on substrate-induced ...
Jiaming Wang, Kang Lv, Yilu Wen, Tao Liu, Changgui Zhao   +4 more
doaj   +1 more source

Carbene organic catalytic planar enantioselective macrolactonization

Nature Communications
Macrolactones exhibit distinct conformational and configurational properties and are widely found in natural products, medicines, and agrochemicals. Up to now, the major effort for macrolactonization is directed toward identifying suitable carboxylic ...
Xiaokang Lv, Fen Su, Hongyan Long, Fengfei Lu, Yukun Zeng, Minghong Liao, Fengrui Che, Xingxing Wu, Yonggui Robin Chi   +8 more
doaj   +1 more source

Bacterial Cytochrome P450 Catalyzed Macrocyclization of Ribosomal Peptides

Macrocyclization is a vital process in the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), significantly enhancing their structural diversity and biological activity.
Xiaoqian Lin, Liu, Jing, Jing Liu, Lin, Xiaoqian, Yong-Xin Li, Longcheng Guo, Wu, Gengfan, Guo, Longcheng, Li, Yong Xin, Liu, Runze, Gengfan Wu, He, Bei Bei, Bei-Bei He, Runze Liu   +13 more
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Rapid and Efficient Methodology to Perform Macrocyclization Reactions in Solid-Phase Peptide Chemistry

, 2003
Solid-phase peptide synthesis and microwave-assisted organic synthesis have been combined in order to speed up drug discovery process of macrocyclization products in high purity and good ...
NOVELLINO, ETTORE, GRIECO, PAOLO, CAMPIGLIA, Pietro, GOMEZ MONTERREY, ISABEL MARIA, CAMPIGLIA P., Paolo Grieco, Isabel Gomez Monterrey, Teresa Lama, Ettore Novellino, LAMA T.   +9 more
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Structure-guided design of picomolar-level macrocyclic TRPC5 channel inhibitors with antidepressant activity

Acta Pharmaceutica Sinica B
Recent advances in ion channel structural biology have enhanced structure-based drug design, yet lipid-occupied binding pockets—often large and flat—remain a major hurdle for developing selective small molecules.
Tong Che, Yixiang Chen, Xinyu Cheng, Han Hu, Xiaoyun Wu, Yuting Zhang, Xiaoqiang Yang, Yinzhen Liu, Hui Liu, Weiwei Nan, Shuangyan Wan, Mingxing Yang, Bo Zeng, Jian Li, Jin Zhang, Bing Xiong   +15 more
doaj   +1 more source