Results 111 to 120 of about 5,793 (229)
Acta Pharmaceutica Sinica BRecent advances in ion channel structural biology have enhanced structure-based drug design, yet lipid-occupied binding pockets—often large and flat—remain a major hurdle for developing selective small molecules.
Tong Che +15 more
doaj +1 more source
, 2014 Citation: 'macrocycle' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.M03662 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire +2 more sources
Characterizing the Macrocyclization Activity of Fungal Polyketide Synthase Thioesterases [PDF]
, 2012 Fungal polyketides are a diverse class of natural products that possess many pharmacological properties, including anticancer properties. These properties are evident in the resorcylic acid lactones, a family of polyketides, including zearalenone and ...
Wirz, Monica Hélène
core
Preparation of penta-azole containing cyclopeptides: challenges in macrocyclization [PDF]
Herein is described the synthesis of several analogs of the natural product IB-01211 from concatenated azoles, via a biomimetic pathway based on cyclization-oxidation of serine containing peptides combined with the Hantzsch synthesis.
Álvarez Domingo, Mercedes +5 more
core
A CONVENIENT SYNTHESIS OF MACROCYCLIC DIAMIDES [PDF]
Journal of Sciences, Islamic Republic of Iran, 1998 Some new macrocyclic dibenzotrioxadiamides, dibenzotetraoxadiamide, dibenzopentaoxadiamide, dibenzothiatrioxadiamide, tribenzotrioxadiamides and tetrabenzohexaoxadiamide (14-21), (26) and (27) have been prepared.
doaj
Drug Discovery Today: Technologies, 2018 Macrocycles are an emerging and largely underexploited part of chemical space where potential drugs for difficult genomic targets can be discovered. Macrocycles can have advantages over their natural twins such as better control over synthesis, physicochemical properties and target binding.
Abdelraheem, Eman M.M. +2 more
openaire +1 more source
A Versatile Strategy for Head-to-Tail Macrocyclization and Traceless Backbone Editing of Short Peptides. [PDF]
J Am Chem SocWall BJ +4 more
europepmc +1 more source
A Cysteine-Dependent Peptide Cyclase with Broad Substrate Tolerance Enables Chemoenzymatic Synthesis of Macolacin Analogs. [PDF]
ACS Chem BiolMorohashi M +7 more
europepmc +1 more source
Reprogramming RiPP scaffolds through skeletal editing unlocks chemical space. [PDF]
Chem SciOgawa H +8 more
europepmc +1 more source