Results 101 to 110 of about 6,559 (227)
, 2016 Efficient Synthetic Access to a New Family of Highly Potent Bryostatin Analogues via a Prins-Driven Macrocyclization ...
Paul A. Wender (1321791) +2 more
core +1 more source
A Flow Chemistry Platform for Photochemical Macrocyclization of Peptides
The importance of macrocyclic peptides in drug discovery has spawned a variety of modern techniques to improve their synthesis. Although photocatalysis is now an indispensable tool in the synthesis of natural products and pharmaceuticals, it is rarely ...
William Neiderer (11073363) +5 more
core +1 more source
, 2016 An efficient synthesis of spiro-fused macrolactams by a multicomponent macrocyclization reaction (MCMR) is reported. The use of highly reactive, transient intermediates in this MCMR permits short reaction times, even at high dilution.
Mark J. Kurth (1328874) +2 more
core +1 more source
Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.Endophytic fungi encode abundant cryptic biosynthetic gene clusters that remain largely silent under conventional cultivation. This review highlights how genome mining, multi‐omics, and cluster activation strategies bridge the BGC‐to‐metabolite gap, enabling the discovery of structurally diverse antibacterial natural products with activity against ...
Farkhod Eshboev +8 more
wiley +1 more source
Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future
Medicinal Research Reviews, Volume 46, Issue 6, Page 1574-1602, November 2026.ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2014 In this review, we describe direct and indirect photochemical approaches that have been developed for the preparation of phthalimide- and naphthalimide-based, lariat-type crown ethers.
Dae Won Cho +2 more
doaj +1 more source
, 2016 A range of multivalent heteroaryl ligands, copper sources, and solvent systems have been investigated for use in CuAAC-mediated macrocyclization reactions.
Gagan Chouhan (1980898) +1 more
core +1 more source
Macrocyclization of Unprotected Peptide Isocyanates
, 2016 A chemistry for the facile two-component macrocyclization of unprotected peptide isocyanates is described. Starting from peptides containing two glutamic acid γ-hydrazide residues, isocyanates can be readily accessed and cyclized with hydrazides of ...
Bradley L. Pentelute (1247046) +3 more
core +1 more source
ChemistryEuropePeptide‐based inhibitors are promising tools to target challenging protein interfaces, yet improving their affinity and drug‐like properties is still a major hurdle.
Michael H. N. Meulendijks +11 more
doaj +1 more source
beta-lactam templated macrocyclization: Synthesis of 12-membered macrolide
, 2005 A novel macrolactonization method was developed using a chiral P-lactam as the template. This novel method features that the macrocyclization is simultaneously achieved while a TBS protected hydroxy group is ...
梁国娟 +5 more
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