Case Studies of the Synthesis of Bioactive Cyclodepsipeptide Natural Products
Molecules, 2013 Cyclodepsipeptide natural products often display intriguing biological activities that along with their complex molecular scaffolds, makes them interesting targets for chemical synthesis.
Markus Kaiser, Sara C. Stolze
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Late‐Stage Functionalization of Peptides on the Solid Phase
Angewandte Chemie International Edition, Volume 65, Issue 31, 27 July 2026.Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner +2 more
wiley +1 more source
Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview
Chemistry – A European Journal, Volume 32, Issue 28, 25 July 2026.The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati +4 more
wiley +1 more source
Observations on the Influence of Precursor Conformations on Macrocyclization Reactions [PDF]
, 2016 Macrocycles hold great promise in drug discovery as an underutilized class of lead compounds. The low abundance of these molecules can, in part, be explained by the inherent difficulties in the synthesis of macrocycles and the lack of general methods for
Clausen, Mads Hartvig +9 more
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Efficient Synthesis of a Range of Benzosubstituted Macrocyclic Diamides [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2000 Some new macrocyclic dibenzotetraoxadiamides, tribenzotetraoxadimides, tribenzopentaoxadiamide, tribenzohexaoxadiamide, and tetrabenzoheptaoxadiamide 15-22 have been prepared.
Hashem Sharghi +2 more
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A new family of ATP-dependent oligomerization-macrocyclization biocatalysts [PDF]
Oligomerization and macrocyclization reactions are key steps in the biosynthesis of many bioactive natural products. Important macrocycles include the antibiotic daptomycin ( 1; ref. 1), the immunosuppressant FK- 506 ( 2; ref.
Barona-Gomez, Francisco +3 more
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Enantio-, atrop-, and diastereoselective macrolactonization to access type III cyclophanes
Nature CommunicationsAlthough chiral substituents have been incorporated into ansa chains to stabilize the conformations of cyclophanes and modulate the biological activities of pharmaceuticals, the asymmetric syntheses of these atropisomers relies on substrate-induced ...
Jiaming Wang +4 more
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Efficient catenane synthesis by cucurbit[6]uril-mediated azide–alkyne cycloaddition
Beilstein Journal of Organic Chemistry, 2018 We report here the efficient synthesis of a series of [3]catenanes featuring the use of cucurbit[6]uril to simultaneously mediate the mechanical and covalent bond formations.
Antony Wing Hung Ng +3 more
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beta-lactam templated macrocyclization: Synthesis of 12-membered macrolide [PDF]
, 2005 A novel macrolactonization method was developed using a chiral P-lactam as the template. This novel method features that the macrocyclization is simultaneously achieved while a TBS protected hydroxy group is ...
梁国娟 +5 more
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Carbene organic catalytic planar enantioselective macrolactonization
Nature CommunicationsMacrolactones exhibit distinct conformational and configurational properties and are widely found in natural products, medicines, and agrochemicals. Up to now, the major effort for macrolactonization is directed toward identifying suitable carboxylic ...
Xiaokang Lv +8 more
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